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Rabeprazole

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Identification
Molecular formula
C18H21N3O3S
CAS number
117976-89-3
IUPAC name
2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazole-5-carboxamidine
State
State

At room temperature, Rabeprazole is in a solid state. It is used as a medication primarily in its sodium salt form, which can be formulated into tablets for oral administration.

Melting point (Celsius)
138.00
Melting point (Kelvin)
411.20
Boiling point (Celsius)
596.30
Boiling point (Kelvin)
869.50
General information
Molecular weight
359.43g/mol
Molar mass
359.4320g/mol
Density
1.3600g/cm3
Appearence

Rabeprazole typically appears as a white to off-white crystalline powder. It is practically insoluble in water and ether, but freely soluble in methanol. Care should be taken to protect it from light as it may degrade upon exposure.

Comment on solubility

Solubility of 2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazole-5-carboxamidine

The solubility of the compound 2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazole-5-carboxamidine, with the chemical formula C18H21N3O3S, can be influenced by several factors. Understanding its behavior in different solvents is important in various applications. Here are some key points to consider:

  • Polarity: The presence of functional groups, such as hydroxyl (-OH) and methoxy (-OCH3), suggests that the compound may exhibit some degree of polarity. This can enhance its solubility in polar solvents like water.
  • Hydrogen Bond Formation: The hydroxyl group can participate in hydrogen bonding, potentially increasing solubility in polar solvents.
  • Sulfur Content: The presence of sulfur in the structure might affect the overall solubility, as sulfide components can interact differently with various solvent systems.
  • pH Dependence: The solubility can also be pH-dependent, particularly in an aqueous medium, due to the presence of the basic carboxamidine group.

In summary, while specific solubility data for this compound may not be readily available, it can be anticipated that its solubility characteristics will vary significantly across different solvents. Solubility data can be crucial for determining the compound's applicability in pharmacological or industrial contexts.

Interesting facts

Interesting Facts about 2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazole-5-carboxamidine

This fascinating compound, a member of the benzimidazole family, is known for its intriguing structural characteristics and potential applications. Here are some remarkable insights:

  • Structural Diversity: The molecule incorporates both aromatic and heterocyclic components, showcasing a blend of phenolic and amide functionalities. This structural complexity can lead to varied interactions within biological systems.
  • Biological Significance: Compounds with a benzimidazole core are often studied for their pharmacological properties, including antimicrobial, anti-inflammatory, and anticancer activities. This specific compound could hold promise for further research in medicinal chemistry.
  • Hydroxyl and Methoxy Groups: The presence of a hydroxyl group and a methoxy substituent enhances the solubility and reactivity of this compound, suggesting potential benefits in drug formulation and delivery.
  • Potential for Research: Due to its unique structure, this compound serves as an excellent scaffold for the design of new drugs. Chemists can modify different portions of the molecule to explore new therapeutic targets.

As John Dalton once said, “All matter is composed of atoms.” This quote indirectly highlights the importance of understanding molecular structures, like that of 2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazole-5-carboxamidine, which underpin the development of effective medicinal compounds.

In summary, the rich chemistry and potential utility of 2-(2-hydroxy-5-methoxy-phenyl)-3H-benzimidazole-5-carboxamidine make it a compound of significant interest in scientific research. Its exploration could lead to breakthroughs in various therapeutic areas.

Synonyms
CHEMBL96493
1gi9
SCHEMBL4315525
BDBM50102782
PD042921
NS00070464