Phosphatidylinositol (3,4,5)-trisphosphate

Identification

Molecular formula

C₄₇H₈₃O₁₉P₃

CAS number

4090-92-4

IUPAC name

2-[2-carboxy-6-(1,2-dihydroxyethyl)-2-[[5-(3-dodecanoyloxytetradecanoylamino)-6-[[3-hydroxy-5-(3-hydroxytetradecanoylamino)-4-(3-hydroxytetradecanoyloxy)-6-phosphonooxy-tetrahydropyran-2-yl]methoxy]-4-(3-hydroxytetradecanoyloxy)-3-phosphonooxy-tetrahydropyran-2-yl]methoxy]-5-hydroxy-tetrahydropyran-4-yl]oxy-6-(1,2-dihydroxyethyl)-4,5-dihydroxy-tetrahydropyran-2-carboxylic acid

State

At room temperature, Phosphatidylinositol (3,4,5)-trisphosphate is typically in a viscous liquid or oily state. It is often manipulated in solution form in biological systems or biochemical applications.

Melting point (Celsius)

-68.00

Melting point (Kelvin)

205.00

Boiling point (Celsius)

255.00

Boiling point (Kelvin)

528.00

General information

Molecular weight

1123.42g/mol

Molar mass

1 123.4200g/mol

Density

1.2000g/cm³

Appearence

Phosphatidylinositol (3,4,5)-trisphosphate usually appears as a viscous liquid or a thick, transparent oil. It may also be provided in a dried powder form for laboratory uses. Its appearance is not particularly distinct, as it is typically handled in solution or within complex lipid mixtures.

Comment on solubility

Solubility of 2-[2-carboxy-6-(1,2-dihydroxyethyl)-2-[[5-(3-dodecanoyloxytetradecanoylamino)-6-[[3-hydroxy-5-(3-hydroxytetradecanoylamino)-4-(3-hydroxytetradecanoyloxy)-6-phosphonooxy-tetrahydropyran-2-yl]methoxy]-4-(3-hydroxytetradecanoyloxy)-3-phosphonooxy-tetrahydropyran-2-yl]methoxy]-5-hydroxy-tetrahydropyran-4-yl]oxy-6-(1,2-dihydroxyethyl)-4,5-dihydroxy-tetrahydropyran-2-carboxylic acid

This complex compound, with the chemical formula C₄₇H₈₃O₁₉P₃, presents unique challenges regarding its solubility. The solubility can be influenced by several factors:

Hydrophilicity vs. Hydrophobicity: The presence of multiple hydroxyl (-OH) and carboxylic acid (-COOH) groups suggests that the compound may possess significant hydrophilic characteristics, potentially enhancing its solubility in polar solvents, such as water.
Chain Length: The long hydrophobic dodecanoyl and tetradecanoyl hydrocarbon chains may lead to decreased solubility in water but could improve solubility in organic solvents or lipids, indicating amphiphilic behavior.
pH Dependence: The carboxylic acid groups could ionize at higher pH levels, thereby increasing solubility in basic solutions.
Interactions: Potential hydrogen bonding and ion-dipole interactions with solvent molecules may further dictate solubility behavior.

Overall, while the diverse functional groups suggest a propensity for solubility in polar environments, the hydrophobic segments indicate that this compound might also show substantial solubility in non-polar solvents, emphasizing the importance of the solvent used in determining its solubility profile.

Interesting facts

Interesting Facts About 2-[2-carboxy-6-(1,2-dihydroxyethyl)-2-[[5-(3-dodecanoyloxytetradecanoylamino)-6-[[3-hydroxy-5-(3-hydroxytetradecanoylamino)-4-(3-hydroxytetradecanoyloxy)-6-phosphonooxy-tetrahydropyran-2-yl]methoxy]-4-(3-hydroxytetradecanoyloxy)-3-phosphonooxy-tetrahydropyran-2-yl]methoxy]-5-hydroxy-tetrahydropyran-4-yl]oxy-6-(1,2-dihydroxyethyl)-4,5-dihydroxy-tetrahydropyran-2-carboxylic acid

This compound is a complex natural product known for its role in biological systems. It possesses a variety of structural components that contribute to its myriad applications in research and industry. Here are some fascinating points about this compound:

Multi-Functional Moiety: Its structure includes multiple hydroxyl groups (-OH), which often enhance solubility and biological activity.
Phosphorylation Sites: The presence of phosphonooxy groups allows for potential interaction with cellular signaling pathways.
Hydroxyethyl Substituents: The 1,2-dihydroxyethyl groups may influence the compound’s affinity for various biological targets, making it a subject of interest in pharmacological studies.
Long-Alkyl Chains: The dodecanoyl group contributes hydrophobic character, which can affect membrane interaction and possibly influence the bio-distribution of the compound within biological systems.
Potential Therapeutics: Compounds of this class could serve as important leads in drug discovery, especially in designing therapeutic agents targeting specific pathways in cell metabolism.

As a scientist or chemistry student, you might find it particularly intriguing to explore the compound's role in cellular processes. Researchers often utilize such compounds to:

Investigate metabolic pathways through biochemical assays.
Develop novel therapeutic strategies for treating diseases.
Explore the interaction of these compounds with cellular membranes, which can yield insights into their bioavailability and mechanism of action.

In summary, this compound exemplifies the complexity often found in natural products, offering a rich field for exploration in both basic and applied sciences. Its intricate structure and diverse functional groups make it a promising candidate for various biomedical applications.