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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl 2-amino-3-methyl-butanoate
State
State

At room temperature, tenofovir is typically found in a solid state. In its disoproxil fumarate form, it is used for oral administration and is stable under normal conditions.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.00
Boiling point (Celsius)
760.00
Boiling point (Kelvin)
1 033.00
General information
Molecular weight
305.28g/mol
Molar mass
287.2410g/mol
Density
1.5000g/cm3
Appearence

Tenofovir is a white to off-white crystalline powder. It is typically provided in its disoproxil fumarate form for pharmaceutical use, which is also a crystalline solid.

Comment on solubility

Solubility of 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl 2-amino-3-methyl-butanoate

The solubility of 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl 2-amino-3-methyl-butanoate (C9H14N5O4P) can be influenced by several factors:

  • Polarity: Given its structure containing both amino and oxy groups, this compound is likely to exhibit moderate polarity, potentially enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of multiple functional groups allows for strong hydrogen bonding interactions, which can facilitate solubility in organic solvents.
  • pH Dependency: The solubility may vary significantly with changes in pH, especially considering the presence of amino groups that can be protonated or deprotonated.
  • Temperature Effects: Typically, an increase in temperature can lead to enhanced solubility for many compounds, including this one.

In practical applications, one can observe that the solubility is often determined empirically, leading to varying reports in the literature. In summary, while this compound is expected to be soluble in polar solvents, quantitative solubility data should be consulted for precise information in laboratory settings.


Interesting facts

Interesting Facts about 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl 2-amino-3-methyl-butanoate

This fascinating compound is notable for its intricate structure and biological significance. The compound contains a purine derivative, which is essential in various biochemical processes, particularly in the synthesis of nucleotides and nucleic acids. Here are some intriguing aspects of this compound:

  • Biological Relevance: The purine moiety plays a critical role in cellular energy transfer, with involvement in ATP (adenosine triphosphate) synthesis.
  • Chirality: The presence of chiral centers due to the butanoate component can lead to different enantiomers, potentially impacting biological activity and pharmacological properties.
  • Synthetic Importance: This compound could serve as a building block in medicinal chemistry to design novel therapeutics, particularly in targeting metabolic pathways related to purine metabolism.
  • Research Interest: Researchers are exploring its effects, especially in relation to genetic expression and enzyme activity within various cells.

As a emerging compound of interest in biochemistry, 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl 2-amino-3-methyl-butanoate exemplifies the exciting intersection of chemistry and biological function. Its complex structure encourages further exploration to unlock potential applications in medicine and biotechnology.