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Diclofenac

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Identification
Molecular formula
C14H11Cl2NO2
CAS number
15307-86-5
IUPAC name
2-(2-acetyl-5-methyl-anilino)-2-(2,6-dichlorophenyl)acetamide
State
State

At room temperature, Diclofenac is in a solid state. It is usually found in the form of tablets, capsules, or as a gel for topical use.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
407.00
Boiling point (Kelvin)
680.15
General information
Molecular weight
296.15g/mol
Molar mass
296.1490g/mol
Density
1.6000g/cm3
Appearence

Diclofenac appears as a white to slightly yellowish crystalline powder.

Comment on solubility

Solubility of 2-(2-acetyl-5-methyl-anilino)-2-(2,6-dichlorophenyl)acetamide

The solubility of the compound 2-(2-acetyl-5-methyl-anilino)-2-(2,6-dichlorophenyl)acetamide (C14H11Cl2NO2) can be intriguing due to its structural characteristics and the presence of multiple functional groups. Generally, the solubility of organic compounds is influenced by a variety of factors including:

  • Polar and Non-Polar Interactions: The presence of the polar amide group may enhance solubility in polar solvents, while the aromatic rings may contribute to solubility in non-polar environments.
  • Hydrogen Bonding: This compound is capable of forming hydrogen bonds due to the amide functionality, which can significantly impact its solubility in water.
  • Impact of Halogen Atoms: The introduction of chlorine atoms may alter the solubility profile, as halogens can influence both polarity and interaction with solvents.
  • Temperature Dependency: Like many organic compounds, solubility can vary with temperature; higher temperatures often increase solubility.

It is likely that 2-(2-acetyl-5-methyl-anilino)-2-(2,6-dichlorophenyl)acetamide exhibits limited water solubility due to its relatively large hydrophobic moieties, while it may show better solubility in organic solvents like ethanol or dimethyl sulfoxide (DMSO). As with many compounds in this class, empirical testing is important to ascertain the exact solubility characteristics.

Interesting facts

Interesting Facts about 2-(2-acetyl-5-methyl-anilino)-2-(2,6-dichlorophenyl)acetamide

This intriguing compound, often referred to for its complex structure and potential applications in medicinal chemistry, encompasses a unique blend of chemical functionalities. Here are some engaging aspects to consider:

  • Structural Complexity: The compound features an aniline group and two distinct aromatic rings, showcasing a rich chemical diversity that can influence its biological activity.
  • Medicinal Potential: Due to the presence of the acetyl and amide moieties, it has been a subject of interest in drug development. Compounds with similar structures often exhibit significant anti-inflammatory and analgesic properties.
  • Color Prediction: The dichlorophenyl group implies potential for interactions that could affect how the compound interacts with biological systems, including enzyme binding sites.
  • Research Focus: Numerous studies explore the implications of similar compounds in treating various diseases, emphasizing the necessity for continued research in this field.

As stated by leading chemists, “Understanding the nuances in structure can unveil new pathways for discovery.” These insights are foundational for students and professionals alike as they dissect the structural aspects and ramifications of such complex compounds.

This compound serves as a prime example of how intricate arrangements in molecular structures contribute to the larger narrative of chemical applications and their roles in advancing therapeutic innovation.

Synonyms
loviride
147362-57-0
R 89439
R-89439
2-(2-acetyl-5-methylanilino)-2-(2,6-dichlorophenyl)acetamide
CHEMBL37624
3S1R1LZ09H
2-((2-acetyl-5-methylphenyl)amino)-2-(2,6-dichlorophenyl)acetamide
141030-40-2
(+/-)-2-(6-ACETYL-M-TOLUIDINO)-2-(2,6-DICHLOROPHENYL)ACETAMIDE
UNII-3S1R1LZ09H
Loviride [USAN:INN:BAN]
Loveride
Lovirida
.alpha.-APA
starbld0009613
LOVIRIDE [USAN]
Loviride (USAN/INN)
LOVIRIDE [INN]
LOVIRIDE [MART.]
LOVIRIDE [WHO-DD]
SCHEMBL247781
DTXSID60869958
CHEBI:230669
(+-)-2-(6-Acetyl-m-toluidino)-2-(2,6-dichlorophenyl)acetamide
BDBM50030539
AKOS040741969
Benzeneacetamide, alpha-((2-acetyl-5-methylphenyl)amino)-2,6-dichloro-
Benzeneacetamide, alpha-((2-acetyl-5-methylphenyl)amino)-2,6-dichloro-, (+-)-
DA-75090
HY-15355
MS-25423
CS-0005982
D04786
G12757
R89439
Q6692646
2-(2-acetyl-5-methyl-anilino)-2-(2,6-dichlorophenyl)acetamide
(+/-)-2,6-Dichloro-.alpha.-[(2-acetyl-5-methylphenyl)amino]benzamide
2-(2-Acetyl-5-methyl-phenylamino)-2-(2,6-dichloro-phenyl)-acetamide
BENZENEACETAMIDE, .ALPHA.-((2-ACETYL-5-METHYLPHENYL)AMINO)-2,6-DICHLORO-, (+/-)-