Skip to main content

Clemastine fumarate

ADVERTISEMENT
Identification
Molecular formula
C25H26ClNO3
CAS number
15376-74-4
IUPAC name
2-[[2-[7-chloro-1-(2,2-dimethylpropyl)-5-(1-naphthyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]butanedioic acid
State
State

At room temperature, Clemastine fumarate is solid, typically in the form of a crystalline powder. It is stable and should be stored in a cool, dry place, away from excessive heat and moisture.

Melting point (Celsius)
165.50
Melting point (Kelvin)
438.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
459.96g/mol
Molar mass
541.0900g/mol
Density
1.4000g/cm3
Appearence

The compound is typically found as a white to off-white powder. It may have a slight odor. Clemastine fumarate is often seen in pharmaceutical settings, particularly in antihistamine medications where it is a primary active ingredient.

Comment on solubility

Solubility of 2-[[2-[7-chloro-1-(2,2-dimethylpropyl)-5-(1-naphthyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]butanedioic acid

The solubility of the compound 2-[[2-[7-chloro-1-(2,2-dimethylpropyl)-5-(1-naphthyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]butanedioic acid (C25H26ClNO3) varies significantly based on several factors due to its complex structure. Understanding its solubility is vital for applications in pharmaceuticals and biochemical research.

Factors Influencing Solubility

  • Polarity: The presence of polar functional groups, particularly the carboxylic acid moieties, suggests that the compound may have moderate solubility in water.
  • Hydrophobic Regions: The significant hydrophobic character introduced by the naphthalene and chloro substituents can lead to lower aqueous solubility levels.
  • Temperature: As with many organic compounds, solubility can improve with increasing temperature, possibly making it more soluble in organic solvents.
  • pH Levels: The solubility may be highly dependent on the pH of the solution, particularly because the carboxylic acid groups can ionize at higher pH levels.

In general, one might expect this compound to exhibit solubility in:

  • Organic solvents: Such as ethanol, methanol, or dimethyl sulfoxide (DMSO).
  • Aqueous solutions: Potentially limited, influenced by its pH.

Conclusion: In conclusion, while the complicated structure of this compound hints at potential solubility issues in water, particularly due to its hydrophobic components, it may find improved solubility profiles in organic solvents and under varied pH conditions. Understanding these solubility characteristics is crucial for its practical applications in biochemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 2-[[2-[7-chloro-1-(2,2-dimethylpropyl)-5-(1-naphthyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]amino]butanedioic acid

This compound is part of a fascinating class of molecules known as benzoxazepins. These compounds have gained notable attention in pharmaceutical chemistry due to their diverse biological activities. Here are some intriguing aspects of this specific benzoxazepin derivative:

  • Structural Complexity: The compound features a complex molecular structure with multiple functional groups, which contributes to its potential reactivity and biological activity.
  • Medicinal Potential: Compounds like this have shown promise in the areas of cancer research and neuropharmacology, making them significant in drug discovery.
  • Chlorine Substitution: The presence of a chlorine atom in the molecule often enhances the compound’s biological activity due to its electronic properties and steric influence.
  • Dimethylpropyl Group: The large alkyl substituent can impact the compound's lipophilicity, which is essential for membrane permeability and bioavailability in drug formulation.
  • Adverse Effects Research: Understanding the pharmacodynamics and pharmacokinetics of such compounds is crucial, as the balance between efficacy and toxicity must be carefully managed in drug development.

As noted by researchers, "The intricate design of these compounds often leads to novel therapeutic avenues." This compound exemplifies how the rich chemistry underlying complex molecules paves the way for innovations in medicine.

The study of such intricate entities not only expands our knowledge base but also supports the quest for new treatments that could improve health outcomes globally. Emphasizing the interdisciplinary nature of modern chemical research is essential, as collaborations between chemists, biologists, and physicians can turn these sophisticated compounds into clinically valuable therapies.