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Diclofenac

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Identification
Molecular formula
C14H11Cl2NO2
CAS number
15307-79-6
IUPAC name
2-[2-(2,6-dichloroanilino)phenyl]acetic acid
State
State
In its pure form, Diclofenac is a solid at room temperature. It is usually used in powdered form for pharmaceutical applications.
Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
343.00
Boiling point (Kelvin)
616.15
General information
Molecular weight
296.15g/mol
Molar mass
296.1490g/mol
Density
1.3560g/cm3
Appearence
Diclofenac appears as an off-white to light yellow solid. It is typically available in powdered form and might have a slightly crystalline structure depending on the specific formulation and processing method.
Comment on solubility

Solubility of 2-[2-(2,6-dichloroanilino)phenyl]acetic acid (C14H11Cl2NO2)

The compound 2-[2-(2,6-dichloroanilino)phenyl]acetic acid exhibits interesting solubility characteristics influenced by its molecular structure. Its solubility can be summarized as follows:

  • Water Solubility: This compound is expected to have limited solubility in water due to the presence of hydrophobic phenyl groups and the bulky chlorinated aromatic structure.
  • Organic Solvents: It is likely more soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). These solvents can provide a better environment for the compound’s aromatic structure to interact.
  • pH Dependency: The solubility of acids can be pH-dependent. As a carboxylic acid, 2-[2-(2,6-dichloroanilino)phenyl]acetic acid may become more soluble in basic conditions due to deprotonation, leading to the formation of an anionic species.
  • Temperature Effects: Solubility generally increases with temperature; thus, elevated temperatures might enhance the dissolution of this compound in suitable solvents.

Overall, while 2-[2-(2,6-dichloroanilino)phenyl]acetic acid may not dissolve well in water, its behavior in organic solvents and under varying pH conditions makes it an interesting compound for further exploration in solubility studies. Understanding these solubility traits can be crucial for applications in pharmaceuticals and chemical manufacturing.

Interesting facts

Exploring 2-[2-(2,6-dichloroanilino)phenyl]acetic Acid

2-[2-(2,6-dichloroanilino)phenyl]acetic acid is a fascinating compound that straddles the fields of organic chemistry and medicinal chemistry. Known for its unique structure, this compound showcases the intricate relationship between chemical configuration and biological activity.

Key Features

  • Complex Structure: The compound features a dichloroaniline moiety which is known for its versatility in various chemical reactions.
  • Biological Relevance: Compounds like this one can serve as important pharmaceuticals or therapeutic agents, often involved in targeting specific biological pathways.
  • Interactions: The presence of chlorine atoms in its structure can significantly influence the compound's reactivity, solubility, and the extent to which it can interact with biological systems.

Applications and Implications

This compound has garnered interest in various research areas, particularly in:

  • Drug Development: Its potential as a scaffold for designing new drugs is noteworthy, particularly for conditions that currently have limited treatment options.
  • Environmental Chemistry: Given its chlorinated nature, understanding how it behaves in environmental systems is crucial, especially regarding its breakdown and potential toxicity.

As chemists delve deeper into the properties and potential applications of 2-[2-(2,6-dichloroanilino)phenyl]acetic acid, they often quote renowned chemist Linus Pauling: "The best way to have a good idea is to have a lot of ideas." This encapsulates the spirit of exploration that compounds like this inspire in the scientific community.

In conclusion, the study of 2-[2-(2,6-dichloroanilino)phenyl]acetic acid reflects the ongoing dialogue between chemistry, biology, and application. Its multifaceted nature opens doors to new discoveries and enhanced understanding of chemical interactions.

Synonyms
diclofenac
15307-86-5
Diclofenac acid
dichlofenac
Diclofenaco
Diclophenac
Diclofenacum
2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid
ProSorb-D
Diclofenac free acid
2-(2,6-Dichloroanilino)phenylacetic Acid
Diclofenac resinate
Voltarol
Zorovolex
Zorvolex
Diclofenamic acid
2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-
2-[2-(2,6-dichloroanilino)phenyl]acetic acid
2-((2,6-Dichlorophenyl)amino)benzeneacetic acid
CHEBI:47381
HSDB 7234
Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-
EINECS 239-348-5
Solaraze
UNII-144O8QL0L1
BRN 2146636
2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid
Voltaren-XR
ACETIC ACID, (o-(2,6-DICHLOROANILINO)PHENYL)-
144O8QL0L1
LAS41007
LAS-41007
MFCD00056694
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid
CHEMBL139
{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID
[2-(2,6-Dichloroanilino)phenyl]acetic acid
DTXSID6022923
EC 239-348-5
15307-86-5 (free)
Olfen
Dicrofenac
Solaraze (TN)
DICLOFENAC (MART.)
DICLOFENAC [MART.]
(O-(2,6-DICHLOROANILINO)PHENYL)ACETIC ACID
Enfenamic acid; N-Phenethylanthranilic acid; RH 8
2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid
(2-((2,6-DICHLOROPHENYL)AMINO)PHENYL)ACETIC ACID
2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetic Acid (Diclofenac)
Diclofenacum [INN-Latin]
Diclofenaco [INN-Spanish]
DIF
(2-(2,6-dichloroanilino)phenyl)acetic acid
ACECLOFENAC IMPURITY A (EP IMPURITY)
ACECLOFENAC IMPURITY A [EP IMPURITY]
(2-((2,6-Dichlorophenyl)amino-phenyl)acetic acid (HD)
Diclofenac [USAN:INN:BAN]
ISV-205
Zorvolex (TN)
57 - Pharmaceuticals
Spectrum_000930
DICLOFENAC [MI]
S17 - Pharmaceuticals
DICLOFENAC [INN]
128402-48-2
Diclofenac (USAN/INN)
Prestwick0_000594
Prestwick1_000594
Prestwick2_000594
Prestwick3_000594
Spectrum2_000991
Spectrum3_000385
Spectrum4_000506
Spectrum5_000867
DICLOFENAC [HSDB]
DICLOFENAC [USAN]
DICLOFENAC [VANDF]
Epitope ID:116873
AM01 - Analgesic mixture
SCHEMBL2799
DICLOFENAC [WHO-DD]
Lopac0_000441
Oprea1_011155
BSPBio_000468
BSPBio_002169
KBioGR_001051
KBioGR_002306
KBioSS_001410
KBioSS_002308
MLS006011795
BIDD:GT0380
DivK1c_000272
DivK1c_000402
SPBio_001081
SPBio_002687
BPBio1_000516
DTXCID802923
GTPL2714
DICLOFENAC [ORANGE BOOK]
BDBM13066
HMS501E04
KBio1_000272
KBio1_000402
KBio2_001410
KBio2_002306
KBio2_003978
KBio2_004874
KBio2_006546
KBio2_007442
KBio3_001389
KBio3_002786
M01AB05
M02AA15
S01BC03
2b17
cMAP_000014
NINDS_000272
NINDS_000402
HMS2090C10
HMS3886F09
BCP09087
BCP13860
s6073
STK984493
AKOS001579542
DB00586
FD30611
KS-1258
IDI1_000272
IDI1_000402
NCGC00021125-01
NCGC00021125-02
NCGC00021125-11
AC-27673
DA-72738
HY-15036
o-(2,6-dichloroanilino)phenylacetic acid
SMR001550371
SY038623
SBI-0051341.P003
Diclofenac 1000 microg/mL in Acetonitrile
D3748
NS00000212
UNM000001216103
[2-(2,6-Dichloroanilino)phenyl]acetic acid #
C01690
D07816
D30801
EN300-119509
H10425
[o-(2,6-dichloro-anilino)-phenyl]-acetic acid
2-[(2,6-dichlorophenyl)amino]phenylacetic acid
AB01275502-01
AB01275502_02
2-(2-(2,6-dichlorophenylamino)phenyl)acetic acid
2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid
2-[(2,6-dichlorophenyl)amino]-phenyl-acetic acid
Q244408
[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid
2-[(2,6-dichlorophenyl)-amino]-benzeneacetic acid
2-[(2,6-dichlorophenyl)-amino]-phenyl-acetic acid
2-[2-(2,6-dichlorophenylamino)phenyl]-acetic acid
SR-01000003041-3
2-[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid
BRD-K08252256-224-02-9
BRD-K08252256-236-05-6
BRD-K08252256-236-17-1
BRD-K08252256-236-32-0
BRD-K08252256-236-33-8
BRD-K08252256-237-02-1
Z57664869
F0722-0745
239-348-5