Skip to main content

Diclofenac

ADVERTISEMENT
Identification
Molecular formula
C14H11Cl2NO2
CAS number
15307-86-5
IUPAC name
2-[2-(2,6-dichloroanilino)phenyl]acetate
State
State

At room temperature, Diclofenac is solid. It is typically utilized in medicinal forms such as tablets or topical gels for its analgesic and anti-inflammatory properties.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
393.80
Boiling point (Kelvin)
666.95
General information
Molecular weight
296.15g/mol
Molar mass
296.1480g/mol
Density
1.4340g/cm3
Appearence

Diclofenac typically appears as a white to slightly yellow crystalline powder. It is not distinctly odorous and is mostly encountered in a formulated state in medications, either as sodium or potassium salts, or as a complex in its unformulated state.

Comment on solubility

Solubility of 2-[2-(2,6-dichloroanilino)phenyl]acetate

The solubility of 2-[2-(2,6-dichloroanilino)phenyl]acetate (C14H11Cl2NO2) can be influenced by a variety of factors including temperature, pH, and the presence of solvents. This compound, with its relatively complex structure, exhibits certain characteristics that can affect its solubility:

  • Polarity: The presence of the dichloroaniline group introduces some polarity, which may enhance solubility in polar solvents like water to some extent.
  • Organic Solvents: It is likely to be more soluble in organic solvents such as ethanol, acetone, or chloroform due to the hydrophobic aromatic portions of its structure.
  • Temperature Effect: Increased temperature generally leads to higher solubility for many organic compounds; therefore, higher temperatures could potentially improve its solubility in suitable solvents.
  • pH Influence: The acidity or basicity of the solvent can alter the ionization state of the compound, thus modifying its solubility properties.

In summary, while 2-[2-(2,6-dichloroanilino)phenyl]acetate may show limited solubility in water, its solubility will likely improve significantly in various organic solvents. Keep in mind that solubility can vary greatly based on experimental conditions.

Interesting facts

Interesting Facts About 2-[2-(2,6-Dichloroanilino)phenyl]acetate

2-[2-(2,6-Dichloroanilino)phenyl]acetate, a compound with intriguing characteristics, is worth exploring for its various applications and functions in both chemistry and biology. Here are some significant points to consider:

  • Structural Complexity: The compound features a complex structure that includes a dichloroaniline moiety, which contributes to its unique chemical properties.
  • Biological Activity: Compounds similar to this have been studied for their potential antimicrobial and antineoplastic properties, showcasing the growing intersection of chemistry and medicine.
  • Pharmaceutical Relevance: Its derivatives might be explored in drug design, particularly in the realm of creating new therapeutic agents.
  • Synthesis Techniques: Understanding the synthesis of such compounds can offer insights into advanced organic synthesis techniques commonly used in academic and industrial laboratories.
  • Environmental Impact: The presence of chlorine atoms suggests that careful consideration of the compound's environmental stability and degradation pathways is essential, particularly when assessing its safety.

In summary, 2-[2-(2,6-dichloroanilino)phenyl]acetate serves as an excellent case study of how a single compound can bridge multiple disciplines, from organic synthesis to biological research. It reminds us that the intricate interplay between structure and function is vital in the field of chemistry.

Synonyms
2-[2-(2,6-dichloroanilino)phenyl]acetate
diclofenac(1-)
{2-[(2,6-dichlorophenyl)amino]phenyl}acetate
Orthophen
Solaraze
Voltaren-XR
86522-08-9
sodium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate
CHEBI:48311
DTXSID201189538
BDBM50174201
NSC755403
STK177318
AKOS000305881
NSC-755403
NCGC00021336-03
NCGC00021336-04
NCGC00021336-05
NCGC00021336-09
AB00053454
AB00053454-16
AB00053454_17
AB00053454_18
AB00053454_19
Q27121136
Sodium; [2-(2,6-dichloro-phenylamino)-phenyl]-acetate
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, ion(1-)