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Bleomycin

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Identification
Molecular formula
C55H84N18O21S2+
CAS number
11056-06-7
IUPAC name
[2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-(4-guanidinobutylcarbamoyl)thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(1H-imidazol-5-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate
State
State

Bleomycin is typically provided as a lyophilized powder for injection, indicating that it is in a solid state at room temperature. It is reconstituted in a liquid form for clinical use.

Melting point (Celsius)
270.00
Melting point (Kelvin)
543.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
1415.44g/mol
Molar mass
1 415.4380g/mol
Density
1.2500g/cm3
Appearence

Bleomycin appears as a white to off-white powder that is used as a chemotherapeutic agent. It is a glycopeptide antibiotic that is used in the treatment of various cancers.

Comment on solubility

Solubility Characteristics

The solubility of the compound named 2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-(4-guanidinobutylcarbamoyl)thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(1H-imidazol-5-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate (C55H84N18O21S2+) is quite complex due to its intricate structure. Typically, the solubility depends on several influencing factors:

  • Hydrophilicity vs. Hydrophobicity: The presence of functional groups like hydroxyls and amines contributes to hydrophilic characteristics, potentially increasing solubility in polar solvents.
  • Polymer Interactions: Due to its large molecular structure, this compound may exhibit interactions with other polymers or biological molecules, affecting solubility.
  • pH Dependency: The ionic nature of the amine groups suggests that pH changes in the solvent can lead to variations in solubility, particularly in aqueous solutions.
  • Temperature Influence: Solubility might increase with temperature, as is common for many chemical compounds, facilitating dissolution in solvents.

In summary, one could say that “solubility is influenced by the delicate balance between molecular interactions and environmental conditions.” Understanding these multifaceted factors is key to predicting the solubility of this intricate compound effectively.

Interesting facts

Interesting Facts about the Compound

This fascinating compound, known for its complex structure and significant biological activity, plays a crucial role in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Role in Drug Development: This compound serves as a potential lead in the development of new therapeutic agents, particularly in treating various diseases where targeting specific biological pathways is essential.
  • Structural Complexity: The intricate design of its multiple functional groups provides opportunities for structure-activity relationship (SAR) studies, helping scientists to optimize the efficacy and selectivity of the compound.
  • Amino Acids Influence: The presence of several amino acid derivatives highlights its relevance in peptide chemistry, making it a subject of interest for studies in enzyme inhibition and receptor binding.
  • Potential Antimicrobial Properties: With its unique thiazole and guanidine units, this compound is under investigation for possible antimicrobial activities, further expanding its significance in therapeutic applications.
  • Insight into Bioactivity: The various substitutions on the pyrimidine and imidazole rings suggest potential interactions with biological macromolecules, paving the way for novel drug designs that target specific cellular pathways.

"Through the lens of chemistry, complexity often leads to innovation." - Anonymous

This compound symbolizes the intersection of synthetic chemistry and pharmacology, reminding us of the endless possibilities that await in the pursuit of new medicinal breakthroughs.

Synonyms
JAA06010