Skip to main content

Bleomycin

ADVERTISEMENT
Identification
Molecular formula
C55H84N17O21S3
CAS number
11056-06-7
IUPAC name
[2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-[3-(dimethyl-lambda4-sulfanyl)propylcarbamoyl]thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(1H-imidazol-5-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate
State
State

Bleomycin is typically found in a solid crystalline state at room temperature. It is often used pharmaceutically in solution form, but as a raw ingredient, it exists as a solid.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
1 454.00
Boiling point (Kelvin)
1 727.15
General information
Molecular weight
1415.57g/mol
Molar mass
1 415.5690g/mol
Density
1.3000g/cm3
Appearence

Bleomycin appears as a pale blue or white powder. It is hygroscopic and sensitive to light.

Comment on solubility

Solubility Characteristics

The solubility of complex compounds such as 2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-[3-(dimethyl-lambda4-sulfanyl)propylcarbamoyl]thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(1H-imidazol-5-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate (C55H84N17O21S3) can be quite nuanced due to its intricate molecular structure. Here are key points regarding its solubility:

  • Solvent Polarity: Compounds with extensive hydrogen bonding and polar functional groups often exhibit better solubility in polar solvents like water.
  • pH Sensitivity: The solubility may vary significantly with changes in pH, especially for compounds containing amino groups, which can be protonated or deprotonated.
  • Temperature Dependence: Increased temperatures often enhance solubility for many organic compounds; thus, experimental conditions can play a pivotal role.
  • Hydrophobic Interactions: Molecules containing large hydrophobic regions might show reduced solubility in water, while potentially increasing in organic solvents.

As such, the practical solubility of this compound is likely a combination of these factors, making it critical to assess its behavior in various solvents to determine the most suitable conditions for its use.

Interesting facts

Interesting Facts about the Compound

This complex molecule holds attention for various reasons, primarily due to its intricate structure and potential biological applications. It's remarkable how compounds like this are synthesized and their roles in medicinal chemistry. Here are some fascinating aspects:

  • Multi-Functional Properties: The compound features several functional groups, making it an interesting subject for studies in drug design. Its ability to bind with various biological targets highlights its potential as a therapeutic agent.
  • Structural Complexity: Comprising multiple amino acids and carbonyl groups, this compound exemplifies the vast diversity of organic molecules. The integration of various substructures allows for a wide range of interactions within biological systems.
  • Potential Applications: Due to its structural resemblance to numerous natural and synthetic pharmaceuticals, it could be explored for its anti-cancer and anti-inflammatory properties. Research in this area is ongoing, providing a promising avenue for future discoveries.
  • Bioavailability Challenges: While introducing compounds with such complexity can enhance efficacy, the challenge remains in ensuring proper bioavailability. Scientists continually investigate ways to improve the transport and absorption of similar compounds within biological environments.
  • Historical Perspective: The development of such compounds is rooted in the quest for novel therapies. As history shows, many medications originated from complex organic compounds, leading to significant breakthroughs in modern medicine.

Quote: "The complexity of a molecule can often reflect the complexity of its potential therapeutic effects."

This compound represents the intersection of chemistry and biology, illustrating the artistry and precision involved in designing molecules for engineering life-saving therapies. Scientists are continually amazed by what these intricate structures can achieve in the lab and beyond.