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Quinapril

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Identification
Molecular formula
C25H30N2O5
CAS number
85441-61-8
IUPAC name
2-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
State
State

At room temperature, Quinapril is a solid crystalline powder.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.20
Boiling point (Celsius)
567.30
Boiling point (Kelvin)
840.50
General information
Molecular weight
438.52g/mol
Molar mass
438.5180g/mol
Density
1.2345g/cm3
Appearence

Quinapril is a white to off-white crystalline substance. It is practically odorless and slightly soluble in water.

Comment on solubility

Solubility of 2-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

The solubility of the compound 2-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid (C25H30N2O5) is influenced by several factors:

  • Polarity: The presence of functional groups, such as the carboxylic acid, can enhance solubility in polar solvents like water.
  • Hydrogen bonding: Functional groups that can form hydrogen bonds may increase the solubility of the compound in polar environments.
  • Molecular size: The relatively large size of this molecule may limit its solubility compared to smaller compounds.
  • pH dependence: The carboxylic acid group may ionize at elevated pH levels, affecting the solubility dynamics in various environments.

In conclusion, while the compound exhibits the potential for solubility in polar solvents due to its functional groups, the overall solubility behavior must be assessed in specific solvents and conditions to gain a comprehensive understanding. Thus, empirical testing is crucial to accurately determine the solubility profile of this complex molecule.

Interesting facts

Interesting Facts about 2-[2-[(1-Ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

This compound represents a fascinating intersection of organic chemistry and medicinal properties. Known for its complex structure, it contains several functional groups that contribute to its reactivity and potential therapeutic applications. Here are some intriguing aspects:

  • Structural Complexity: The unique combination of an isoquinoline backbone and various substituents provides this compound with a rich chemical profile, making it a subject of interest in synthetic organic chemistry.
  • Pharmacological Potential: Due to its structured nature, compounds like this one are often investigated for their ability to interact with biological systems, potentially serving as drug candidates for conditions such as cancer or neurological disorders.
  • Pivotal Functional Groups: The presence of amino and carboxylic acid moieties suggests that this compound may exhibit acidic and basic properties, which can play a crucial role in solubility and reactivity.
  • Research Applications: Scientists are intrigued by how compounds with such structural features can lead to the development of novel therapeutic agents, fostering significant research in medicinal chemistry.

In a quote, a renowned chemist once stated, "The beauty of chemistry lies in understanding how the smallest changes in structure can lead to profound effects in properties." This statement aptly describes the potential of compounds like 2-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid in advancing the field of drug development.

Overall, this compound exemplifies the intricate relationship between structure and function, underscoring why chemists continue to explore the vast diversity of organic molecules.

Synonyms
82768-84-1
CI-906 (free acid)
2-[n-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CHEMBL23389
SCHEMBL678447
DTXSID40861051
EBC02979
NCGC00389414-01
EN300-296321
2-{2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
3-Isoquinolinecarboxylic acid, 2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-