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Fluocinolone acetonide acetate

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Identification
Molecular formula
C26H32FNO7
CAS number
12795-28-9
IUPAC name
[2-(12-fluoro-11-hydroxy-9,13-dimethyl-16-oxo-spiro[5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-diene-6,1'-cyclopentane]-8-yl)-2-oxo-ethyl] acetate
State
State

This compound is typically found as a solid at room temperature. It is stable under normal conditions and retains its form as a white crystalline powder.

Melting point (Celsius)
280.00
Melting point (Kelvin)
553.15
Boiling point (Celsius)
393.00
Boiling point (Kelvin)
666.15
General information
Molecular weight
526.57g/mol
Molar mass
526.5650g/mol
Density
1.1900g/cm3
Appearence

The compound typically appears as a white crystalline powder. It is often used in its pure form and needs to be handled carefully to maintain its stability and efficacy.

Comment on solubility

Solubility Insight for [2-(12-fluoro-11-hydroxy-9,13-dimethyl-16-oxo-spiro[5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-diene-6,1'-cyclopentane]-8-yl)-2-oxo-ethyl] acetate

The solubility of the compound C26H32FNO7 is an intriguing aspect, as it reflects the interactions of its unique structural features in various solvents. Generally, several factors influence solubility, and they can be summarized as follows:

  • Polarity: The presence of polar functional groups, such as the hydroxyl (-OH) and acetate (-COO-) moieties, suggests that this compound may exhibit moderate to high solubility in polar solvents like water and alcohols.
  • Hydrophobic Regions: The large hydrophobic portion of the compound, owing to its complex ring structures, may hinder solubility in very polar solvents but enhance it in less polar organic solvents, such as chloroform or ethyl acetate.
  • Fluorine Influence: The incorporation of fluorine can alter solubility characteristics, often increasing chemical resistance and affecting the overall polarity.

In summary, one might conclude that the solubility of this compound can be characterized as variable, being influenced by its intricate architecture and the solvent system utilized. As a general rule, like dissolves like, making solvent polarity a key determinant in predicting solubility outcomes.

Interesting facts

Interesting Facts about [2-(12-fluoro-11-hydroxy-9,13-dimethyl-16-oxo-spiro[5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-diene-6,1'-cyclopentane]-8-yl)-2-oxo-ethyl] acetate

This compound, characterized by its complex structure, offers a tantalizing glimpse into the world of organic chemistry and medicinal applications. Here are some fascinating aspects of this unique molecule:

  • Diverse Molecular Features: The compound boasts multiple functional groups, including ketones and esters, which contribute to its versatile reactivity.
  • Spirocyclic Structure: It incorporates a spiro compound configuration, which enhances its structural rigidity and potential biological activity, paving the way for novel drug candidates.
  • Fluorine Substitution: The presence of fluorine in its structure may influence various properties such as lipophilicity, metabolic stability, and biological efficacy.
  • Potential Applications: Considered for pharmacological research, this compound might exhibit intriguing properties in fields such as cancer therapy, anti-inflammatory agents, or as a scaffold for new drug designs.
  • Synthetic Challenges: The complexity of the synthesis path for this compound reflects the challenges chemists face when creating intricate structures, often requiring advanced techniques and careful planning.

A chemist once remarked, "The beauty of organic synthesis lies in the endless creativity of molecules, from which we can unlock untold therapeutic secrets." Such a statement resonates deeply in the context of this compound, whose elaborate nature hints at its promising future in scientific research and medicine.

In summary, [2-(12-fluoro-11-hydroxy-9,13-dimethyl-16-oxo-spiro[5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-diene-6,1'-cyclopentane]-8-yl)-2-oxo-ethyl] acetate exemplifies the fascinating intersection of complex chemistry and potential real-world applications.

Synonyms
Amciderm
Penticort
[2-(12-fluoro-11-hydroxy-9,13-dimethyl-16-oxospiro[5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-diene-6,1'-cyclopentane]-8-yl)-2-oxoethyl] acetate
Amcinonid
CPD001491664
CHEMBL4518366
SCHEMBL13026154
CHEBI:94333
DTXSID20860623
ILKJAFIWWBXGDU-UHFFFAOYSA-N
HMS3259P07
NC00630
BRD-A16478930-001-01-0
(11.beta.,16.alpha.)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione
[2-[(1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-9,13-dimethyl-16-oxospiro[5,7-dioxapentacyclo[10.8.0.0^{2,9.0^{4,8.0^{13,18]icosa-14,17-diene-6,1'-cyclopentane]-8-yl]-2-oxoethyl] acetate
2-(4'b-Fluoro-5'-hydroxy-4'a,6'a-dimethyl-2'-oxo-2',4'a,4'b,5',6',6'a,9'a,10',10'a,10'b,11',12'-dodecahydro-6'bH-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol]-6'b-yl)-2-oxoethyl acetate
9-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclopentanone, 21-acetate