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Paclitaxel

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Identification
Molecular formula
C47H51NO14
CAS number
33069-62-4
IUPAC name
2-[1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-en-17-yl]ethyl N-benzylcarbamate
State
State

At room temperature, Paclitaxel is a solid substance, typically found in a crystalline form.

Melting point (Celsius)
213.00
Melting point (Kelvin)
486.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
853.91g/mol
Molar mass
853.9060g/mol
Density
1.7400g/cm3
Appearence

Paclitaxel appears as a white to off-white crystalline powder, with no specific odor.

Comment on solubility

Solubility of 2-[1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-en-17-yl]ethyl N-benzylcarbamate: C47H51NO14

The solubility of this complex compound can be influenced by various factors, including its intricate structure and the presence of multiple functional groups. Key aspects to consider include:

  • Polarity: The presence of polar hydroxyl (-OH) groups typically enhances solubility in polar solvents, potentially increasing affinity for water.
  • Functional Groups: The compound contains several methoxy (-OCH3) and dimethoxy groups, which could enhance solubility in organic solvents.
  • Hydrophobic Regions: The significant presence of hydrophobic cyclohexyl segments may lead to decreased solubility in water and favor solubility in non-polar solvents.
  • Temperature and pH: Changes in temperature can affect solubility; generally, an increase in temperature enhances solubility in solid compounds. pH may also impact ionization of functional groups.

It's critical to note that while the structure suggests potential solubility in various solvents, specific solubility data must be obtained through empirical testing. As is often emphasized, "The devil is in the details," and the actual solubility can vary based on precise conditions and interactions within a solvent system.

Interesting facts

Interesting Facts about 2-[1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-en-17-yl]ethyl N-benzylcarbamate

This compound is a fascinating example of a complex organic molecule boasting a detailed structure and multiple functional groups that contribute to its chemical properties. Here are some engaging facets that highlight its significance:

  • Unique Structure: The molecular backbone consists of an intricate arrangement with both cyclohexyl and azatricyclo components, showcasing the beauty of organic synthesis.
  • Functional Diversity: With multiple hydroxyl (-OH) and methoxy (-OCH3) groups, this compound exhibits potential for various biological activities, which can be explored for therapeutic uses.
  • Research Potential: The presence of multiple methoxy and hydroxyl groups suggests that the compound may exhibit interesting properties in medicinal chemistry, such as anti-inflammatory or antioxidant activities.
  • Carbamate Linkage: The N-benzylcarbamate moiety introduces a nitrogen-containing functionality that is crucial for a variety of chemical reactivities, making it potentially useful in drug development.

As voiced by a notable chemist, *“The complexity of organic compounds is a testament to the creativity of nature and the ingenuity of human synthesis.”* This statement truly encapsulates the essence of compounds like this one. Furthermore, ongoing studies into compounds of this nature may lead to innovative breakthroughs in pharmaceuticals, paving the way for new treatments that could significantly impact human health.


In conclusion, the exploration of 2-[1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-en-17-yl]ethyl N-benzylcarbamate represents both a scientific challenge and an opportunity to unearth new insights into the realm of organic chemistry and its applications in various fields.