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Prednisolone phosphate

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Identification
Molecular formula
C21H29O8P
CAS number
125-02-0
IUPAC name
[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] dihydrogen phosphate
State
State

Prednisolone phosphate is typically found in a solid state at room temperature, appearing as a crystalline powder.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
460.48g/mol
Molar mass
460.4760g/mol
Density
1.4900g/cm3
Appearence

Prednisolone phosphate appears as a white to practically white, crystalline powder. It is generally odorless and is hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility Characteristics

The compound [2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] dihydrogen phosphate (C21H29O8P) presents intriguing solubility properties that warrant attention. Generally, the solubility of a compound is influenced by its polarity, structural features, and the nature of the solvent.


Consider the following factors:

  • Polarity: The presence of multiple hydroxyl groups and a phosphate group suggests a degree of polarity, which may enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl groups can facilitate hydrogen bonding, potentially leading to higher solubility in aqueous environments.
  • Hydrophobic Regions: The complex structure and hydrophobic segments may limit solubility in purely aqueous media, potentially necessitating the use of organic solvents or micellar systems.

Water solubility may vary under different pH conditions, thus creating opportunities for therapeutic applications where solubility can enhance bioavailability. There are cases where compounds fall into the category of poorly soluble drugs, requiring innovative formulation strategies to improve their effective delivery.


In conclusion, while [2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] dihydrogen phosphate presents promising pathways for solubility, its unique chemical structure necessitates further study to optimize its practical applications.

Interesting facts

Interesting Facts about 2-(11,17-Dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl dihydrogen phosphate

This intricate compound is a fascinating example of how complex organic molecules can influence biological systems. Here are some remarkable aspects of this compound:

  • Hormonal Influence: The structure of this compound suggests it may have connections to steroid hormones, which are known for their vital roles in regulating biological processes such as metabolism, immune response, and reproduction.
  • Phosphorylation Potential: As a dihydrogen phosphate derivative, it possesses the ability to undergo phosphorylation, a critical biochemical modification that can alter the function of proteins and enzymes.
  • Polyfunctional Nature: The presence of multiple functional groups, like hydroxyl and keto groups, indicates that this compound may engage in various chemical reactions, enhancing its versatility in research and medical applications.
  • Natural Product Chemistry: The complex structure hints at potential natural product origins. Natural products often inspire novel medications and provide insight into the diversity of life forms.

Overall, the intricate chemical architecture of this compound exemplifies the beauty of organic chemistry and its relevance to fields such as pharmacology, biochemistry, and molecular biology. As aptly put by chemical researchers, “The complexity of a molecule can often reflect its biological significance.”

Synonyms
Corphos
11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl dihydrogen phosphate
CHEMBL4793724
SCHEMBL13026155
DTXSID50859843
CHEBI:188822
NSC529660
Hydrocortisone 21-dihydrogen phosphate
[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] dihydrogen phosphate
Pregn-4-ene-3, 11,17-dihydroxy-21-(phosphonooxy)-, (11.beta.)-