Skip to main content

Tolmetin

ADVERTISEMENT
Identification
Molecular formula
C15H15NO3
CAS number
26171-23-3
IUPAC name
2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid
State
State

At room temperature, Tolmetin exists in a solid state, specifically as a crystalline powder, typical of many pharmaceutical compounds.

Melting point (Celsius)
161.00
Melting point (Kelvin)
434.00
Boiling point (Celsius)
447.50
Boiling point (Kelvin)
720.70
General information
Molecular weight
273.28g/mol
Molar mass
273.3310g/mol
Density
1.2470g/cm3
Appearence

Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) that typically appears as a white to off-white crystalline powder. Its crystalline nature leads to a solid appearance with a slightly translucent to opaque finish.

Comment on solubility

Solubility of 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid

The solubility of 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid (C15H15NO3) is influenced by its unique molecular structure, which plays a significant role in its interactions with solvents. Understanding this solubility can help elucidate its behavior in various chemical environments.

Key Factors Affecting Solubility:

  • Polarity: The presence of functional groups such as the acetic acid moiety contributes to its polar nature, which can enhance its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds allows for increased solubility in solvents that can participate in such interactions.
  • Structural Characteristics: The aromatic and pyrrolidine rings provide hydrophobic regions which may limit solubility in water but improve compatibility in organic solvents.

As a general observation, compounds with mixed characteristics exhibit varied solubility depending on the solvent. Therefore, it is often useful to perform solubility tests under specific conditions. For instance, this compound may be more soluble in:

  1. Organic Solvents: Such as ethanol or methanol due to its hydrophobic aromatic regions.
  2. Polar Solvents: Although less soluble in water, it might still show some solubility due to the carboxylic acid's capacity to ionize.

In conclusion, while the solubility of 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid is favorable in certain environments, experimental validation is essential to accurately determine its behavior in various solvents.

Interesting facts

Interesting Facts About 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic Acid

This intriguing compound belongs to the class of substituted pyrroles, a structure that is often explored in medicinal chemistry due to their diverse biological activities. The presence of a pyrrole ring facilitates interesting topological properties that make it an essential framework in pharmacology. Below are some key points to consider:

  • Biological Relevance: Compounds containing pyrrole rings, like this one, have garnered significant interest for their potential anti-inflammatory and analgesic properties.
  • Functional Versatility: The acetic acid moiety adds a layer of functionality that can influence the compound's interactions with biological targets, thereby broadening its applications.
  • Structure-Activity Relationship (SAR): Changes in the methyl and benzoyl groups can significantly alter the compound’s activity, making it a valuable candidate for structure-activity relationship studies.
  • Drug Development: Due to its unique structure, it could serve as a lead compound in the design of new therapeutics aimed at treating conditions like pain and inflammation.

As noted by many researchers, "the intricate balance of electronic and steric factors can lead to the discovery of novel agents with enhanced efficacy." The study of such compounds showcases the beauty of **synthetic organic chemistry** in developing substances that hold promise for innovative medicinal applications. The chemical community continues to explore compounds like 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid to uncover their potential in drug design.

Synonyms
tolmetin
26171-23-3
1-Methyl-5-p-toluoylpyrrole-2-acetic acid
Tolmetine
Tolectin
Tolmetina
Tolmetinum
Tolmetino
1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-
Tolmetina [DCIT]
McN-2559
Tolmetine [INN-French]
Tolmetinum [INN-Latin]
Tolmetino [INN-Spanish]
2-(1-METHYL-5-(4-METHYLBENZOYL)-1H-PYRROL-2-YL)ACETIC ACID
MCN 2559
2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid
1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid
5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid
HSDB 3403
UNII-D8K2JPN18B
EINECS 247-497-2
D8K2JPN18B
Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico
Pyrrole-2-acetic acid, 1-methyl-5-p-toluoyl-
BRN 0485305
2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
CHEBI:71941
1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid
CHEMBL1020
DTXSID2043951
2-{1-methyl-5-[(4-methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetic acid
5-22-06-00392 (Beilstein Handbook Reference)
[1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
Tolmetine (INN-French)
Tolmetinum (INN-Latin)
Tolmetino (INN-Spanish)
1-Methyl-5-p-toluoyl-pyrrole-2-acetic acid
Tolmetin (USAN/INN)
McN-2559-21-98
(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetic acid
Tolmetin [USAN:INN:BAN]
Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico [Spanish]
MFCD00599595
Tolmetin (Standard)
Spectrum_000935
TOLMETIN [HSDB]
TOLMETIN [USAN]
TOLMETIN [INN]
TOLMETIN [JAN]
TOLMETIN [MI]
TOLMETIN [VANDF]
Prestwick0_000856
Prestwick1_000856
Prestwick2_000856
Prestwick3_000856
Spectrum2_001205
Spectrum3_000603
Spectrum4_000359
Spectrum5_001194
TOLMETIN [WHO-DD]
SCHEMBL3150
Oprea1_869397
BSPBio_000871
BSPBio_002106
KBioGR_000797
KBioSS_001415
BIDD:GT0468
DivK1c_000213
SPBio_000990
SPBio_002792
BPBio1_000959
GTPL7311
DTXCID0023951
HY-B1799R
KBio1_000213
KBio2_001415
KBio2_003983
KBio2_006551
KBio3_001606
2-[1-methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid
M01AB03
M02AA21
NINDS_000213
HMS2090D06
HMS3886I03
BCP09085
HY-B1799
BDBM50295287
s4832
AKOS015850645
CCG-267033
CS-W008734
DB00500
GS-6529
SB63879
IDI1_000213
NCGC00094796-03
1-Methyl-5-p-toluoylpyrrole-2-aceticacid
DA-59939
FM140506
SBI-0051537.P002
NS00008120
1-methyl- 5-(p-toluoyl)pyrrole-2-acetic acid
C07149
D02355
EN300-6482019
1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetic acid
Q3992411
BRD-K82562631-236-02-0
BRD-K82562631-236-04-6
BRD-K82562631-325-03-9
BRD-K82562631-325-04-7
F6782-4251
Z1741975772
[1-Methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid
[1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid #
[1-Methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid(tolmetin)
247-497-2
TLT