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LR-5182

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Identification
Molecular formula
C23H29NO3
CAS number
104305-70-8
IUPAC name
2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one
State
State
This compound is typically a solid at room temperature.
Melting point (Celsius)
88.50
Melting point (Kelvin)
361.65
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
359.45g/mol
Molar mass
359.4540g/mol
Density
1.1600g/cm3
Appearence
.

LR-5182 typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one

The solubility of 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one (C23H29NO3) can be influenced by several factors, primarily dictated by its molecular structure and the presence of functional groups. This compound contains both hydrophobic and hydrophilic characteristics due to its complex structure:

  • Hydrophobic Groups: The indanone moiety and the benzyl group contribute to hydrophobicity, which tends to reduce water solubility.
  • Hydrophilic Functional Groups: The methoxy groups offer some level of polarity, potentially enhancing solubility in organic solvents.

As a general observation:

  • The compound is likely to exhibit low solubility in water due to the predominance of hydrophobic characteristics.
  • It may show better solubility in organic solvents such as ethanol, methanol, or DMSO, where its molecular interactions can be more favorable.

In summary, the solubility of 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one is largely dictated by its complex balance of hydrophobic and hydrophilic components, making it an intriguing substance in the study of chemical compounds.

Interesting facts

Interesting Facts about 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one

2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one is a fascinating organic compound that belongs to the indanone class of compounds. This chemical is particularly interesting due to its unique structure and potential applications in medicinal chemistry.

Unique Structural Features

  • Indanone Core: The compound possesses an indanone scaffold, which is notable for its ability to contribute to various biological activities.
  • Piperidine Ring: The presence of a piperidyl group may offer the compound interesting pharmacological properties, often seen in various therapeutic agents.
  • Methoxy Groups: The two methoxy substituents at positions 5 and 6 enhance the compound's lipophilicity, which can influence its bioavailability.

Potential Applications

This compound has garnered attention for its prospective uses in drug development:

  • CNS Activity: Given the structure, it might exhibit activity on the central nervous system, making it a candidate for treating neurological disorders.
  • Antidepressant Properties: Research in similar compounds has suggested potential antidepressant effects, warranting further investigation.
  • Analgesic Effects: The unique blend of functional groups could lead to analgesic properties, presenting a possible pathway for pain management medications.

Research and Development

The synthesis and optimization of this compound continue to be a subject of research, where scientists explore modifications to enhance efficacy and reduce side effects. The ability to manipulate the structure leads to the generation of derivatives with potentially improved biological activities.

In the words of a researcher, “Every modification tells a story about the compound's interaction with its biological target; it’s crucial to understand these interactions for therapeutic advancement.

The synthesis of such compounds serves as an excellent educational opportunity for chemistry students, demonstrating the intersection of organic synthesis and pharmacology.

Synonyms
donepezil
120014-06-4
2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Aricept
donepezilo
Donaz
donepezilum
Domepezil
HSDB 7743
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
UNII-8SSC91326P
142057-79-2
CHEBI:53289
8SSC91326P
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
CHEMBL502
D-797
DTXSID8048317
D797
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-
2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one
Donepezil [INN:BAN]
(+/-)-2-((1-BENZYL-4-PIPERIDYL)METHYL)-5,6-DIMETHOXY-1-INDANONE
(RS)-2-[(1-BENZYL-4-PIPERIDYL)METHYL]-5,6-DIMETHOXYINDAN-1-ONE
2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inden-1-one
5,6-DIMETHOXY-2-((1-(PHENYLMETHYL)-4-PIPERIDINYL)METHYL)-2,3-DIHYDRO-1H-INDEN-1-ONE
NSC 737535
NSC 758882
NCGC00167537-01
(S)-E2020 (free base)
Allydone (TN)
Donepezil; 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine; (+/-)-E 2020
MFCD00912833
donepezil hydrochlorid
Donaz (TN)
Donepezil (Standard)
Spectrum_001664
Donepezil (JAN/INN)
DONEPEZIL [INN]
DONEPEZIL [JAN]
DONEPEZIL [MI]
DONEPEZIL [HSDB]
Spectrum5_001662
DONEPEZIL [VANDF]
DONEPEZIL [WHO-DD]
SCHEMBL2149
Oprea1_188452
KBioSS_002144
BDBM8960
GTPL6599
SCHEMBL8265876
DTXCID0028292
KBio2_002144
KBio2_004712
KBio2_007280
N06DA02
CHEBI:145499
BCPP000253
HMS3886M11
BCP07590
VEA01406
HY-14566R
s5073
STK003905
AKOS000277311
AKOS016842349
AC-6969
BCP9000622
CCG-268401
DB00843
FD29053
MRF-0000323
HY-14566
SBI-0206789.P001
NS00008580
D07869
EN300-267872
AB00640013-07
AB00640013-08
AB00640013_09
AB00640013_10
Q415081
BRD-A49160188-003-04-4
BRD-A49160188-003-11-9
BRD-A49160188-003-12-7
Z1741977105
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
(+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one
2-[(1-benzyl-4-piperidyl)methyl]- 5,6-dimethoxy-2,3-dihydroinden-1-one
2,3-dihydro-5,6-dimethoxy-2 [[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one
2,3-dihydro-5,6-dimethoxy-2[[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one
5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one
2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochlorideDonepezil Hcl