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Angiotensin II

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Identification
Molecular formula
C50H71N13O12
CAS number
68521-68-2
IUPAC name
2-[[1-[[1-[(1-formyl-4-guanidino-butyl)carbamoyl]-2-methyl-propyl]carbamoyl]-4-guanidino-butyl]carbamoylamino]-3-phenyl-propanoic acid
State
State

At room temperature, angiotensin II is a solid. It is typically manufactured and handled as a powder for its use in research and clinical applications.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
1046.19g/mol
Molar mass
1 046.1880g/mol
Density
1.3500g/cm3
Appearence

Angiotensin II is a peptide hormone which appears as a crystalline powder in its pure form. It is typically colorless to white when isolated.

Comment on solubility

Solubility of 2-[[1-[[1-[(1-formyl-4-guanidino-butyl)carbamoyl]-2-methyl-propyl]carbamoyl]-4-guanidino-butyl]carbamoylamino]-3-phenyl-propanoic acid

The solubility of complex compounds such as 2-[[1-[[1-[(1-formyl-4-guanidino-butyl)carbamoyl]-2-methyl-propyl]carbamoyl]-4-guanidino-butyl]carbamoylamino]-3-phenyl-propanoic acid (C50H71N13O12) can be influenced by various factors:

  • Polarity: The presence of multiple hydrophilic (water-attracting) groups, such as guanidine and carboxylic acid functional groups, tends to enhance solubility in polar solvents like water.
  • Molecular Weight: With a high molecular weight, solubility can be more limited; compounds of this size often require organic solvents or specific conditions to dissolve effectively.
  • pH Levels: The solubility may vary significantly with pH changes, particularly due to the ionization of acidic or basic functional groups, which can either promote or hinder solubility.
  • Temperature: Increasing temperature generally enhances solubility for many organic compounds, although this is not a universal rule.

Given the structure’s size and complexity, it’s likely that this compound displays limited solubility in nonpolar solvents, but better solubility in polar solvents, especially under specific conditions that favor the ionization of its functional groups. Understanding these factors can illuminate the behavior of such compounds in various environments.


Interesting facts

Interesting Facts about 2-[[1-[[1-[(1-formyl-4-guanidino-butyl)carbamoyl]-2-methyl-propyl]carbamoyl]-4-guanidino-butyl]carbamoylamino]-3-phenyl-propanoic acid

This complex compound represents a fascinating intersection of organic chemistry and pharmacology, showcasing the intricate relationships between molecular structure and biological function. Here are some compelling points to consider:

  • Structural Complexity: The compound contains multiple guanidine groups and a lengthy carbon chain, contributing to its unique three-dimensional structure which plays a significant role in its biological interactions.
  • Potential Biological Activity: Compounds with similar structures often exhibit significant pharmacological properties such as anti-inflammatory and anti-cancer effects. Researchers are intrigued by this compound's potential therapeutic applications.
  • Applications in Drug Design: The guanidine group is known for its role in biological systems, particularly affecting ion channels and receptors. Incorporating this group into drug design may enhance potency and selectivity.
  • Interdisciplinary Studies: This compound exemplifies the collaboration between chemistry, biology, and medicine, illustrating the need for interdisciplinary approaches to tackle complex health challenges.
  • Challenges in Synthesis: The synthesis and characterization of such elaborate compounds can be intricate, requiring advanced techniques and careful optimization to achieve high yields and purity.

"Understanding the structure-activity relationship of this compound could unveil new pathways for drug discovery."

In summary, the multifaceted nature of 2-[[1-[[1-[(1-formyl-4-guanidino-butyl)carbamoyl]-2-methyl-propyl]carbamoyl]-4-guanidino-butyl]carbamoylamino]-3-phenyl-propanoic acid makes it a subject of great interest within the scientific community and opens avenues for innovative research and development.

Synonyms
Antipain
Antipain (dihydrochloride)
37691-11-5
L-Valinamide,N2-[[(1-carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-
Antipain (Synthetic)
[(S)-1-Carboxy-2-phenyl-ethyl]-carbamoyl-Arg-Val-Arg-aldehyde
SCHEMBL14038024
IAP-3996-PI
CHEBI:181808
HMS3369O02
AKOS040741151
NCGC00390338-01
2-[[5-(diaminomethylideneamino)-1-[[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamoylamino]-3-phenylpropanoic acid