Codeine | Solubility of Things

Identification

Molecular formula

C₁₈H₂₁NO₃

CAS number

76-57-3

IUPAC name

(1S,6R,13S)-6-isopropenyl-16,17-dimethoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one

State

At room temperature, codeine is typically found as a solid. It is frequently processed into tablets, capsules, or syrups for medicinal use due to its analgesic properties.

Melting point (Celsius)

154.00

Melting point (Kelvin)

427.15

Boiling point (Celsius)

250.00

Boiling point (Kelvin)

523.15

General information

Molecular weight

317.36g/mol

Molar mass

317.3640g/mol

Density

1.2500g/cm³

Appearence

Codeine is typically encountered as a white or slightly off-white crystalline powder. It may also appear as translucent crystals. It is almost odorless and has a bitter taste.

Comment on solubility

Solubility of (1S,6R,13S)-6-isopropenyl-16,17-dimethoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one

The solubility of (1S,6R,13S)-6-isopropenyl-16,17-dimethoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one can vary significantly based on various factors.

Polarity: Due to its complex structure, the overall polarity of this compound is crucial in determining its solubility. Generally, compounds with similar polarity to the solvent are more soluble.
Solvent Type:
- Organic Solvents: This compound may show higher solubility in organic solvents such as ethanol, methanol, or dichloromethane.
- Aqueous Solutions: Solubility in water may be limited due to its hydrophobic regions.
Temperature: Increasing temperature often enhances solubility, allowing this molecule to dissolve more readily under certain conditions.

As a result, it is essential to conduct specific tests to determine the solubility of this compound in various solvents and under different conditions. The interplay of these factors can lead to a wide range of solubility behaviors. In summary, "the solubility of a compound is a complex interplay of its structure and the properties of the solvent" that must be explored thoroughly.

Interesting facts

Interesting Facts about (1S,6R,13S)-6-isopropenyl-16,17-dimethoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one

This fascinating compound is known for its complex structure and unique properties. It belongs to the class of natural products and is particularly notable for its potential applications in various fields of research and industry. Here are some key highlights:

Natural Origin: This compound can be derived from certain plants, suggesting potential therapeutic properties that can be harnessed in medicinal chemistry.
Architectural Complexity: The intricate bicyclic and tricyclic systems showcase the richness of organic chemistry, particularly in the construction of polycyclic frameworks.
Potential Biological Activity: Preliminary studies indicate that compounds with similar structures often exhibit a range of biological activities, including antimicrobial and anti-inflammatory effects.
Chirality: Featuring multiple stereocenters, the compound's stereochemistry is vital for its biological activity, making it an interesting subject for studies in stereochemistry and asymmetric synthesis.

As researchers continue to explore its properties, the compound holds promise for advancements in pharmacology, offering new avenues for drug design. The intricate nature and potential utility of (1S,6R,13S)-6-isopropenyl-16,17-dimethoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one exemplify the wonders of organic compounds in both theoretical and applied chemistry.

Synonyms

rotenone

83-79-4

Dactinol

Paraderil

Barbasco

Tubatoxin

(-)-Rotenone

Derris

(-)-cis-Rotenone

Derrin

Nicouline

Rotocide

Noxfire

Ronone

Rotenon

Rotenox

Canex

Deril

Liquid Derris

Cube-Pulver

Dri-Kil

Rotessenol

Prentox

Rotefive

Rotefour

Tubotoxin

Cubor

Extrax

Haiari

Mexide

Chem-Mite

Pb-nox

Cenol garden dust

Curex flea duster

Gerane

Ro-Ko

Synpren

Derris (insecticide)

Caswell No. 725

Rotenox 5EC

Foliafume E.C.

5'-beta-Rotenone

Green Cross Warble Powder

CCRIS 895

Rotenone [BSI:ISO]

Rotenone, dehydro

HSDB 1762

Rotacide E.C.

ENT 133

Rotenone, commercial

EPA Pesticide Chemical Code 071003

NCI-C55210

AI3-00133

NSC26258

EINECS 201-501-9

NSC 26258

Derris, JMAF

UNII-03L9OT429T

DTXSID6021248

CHEBI:28201

03L9OT429T

ROTENONE [HSDB]

ROTENONE [ISO]

ROTENONE [MI]

NSC-26258

ROTENONE [MART.]

(1S,6R,13S)-16,17-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one

1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one

Rotenona

ROTENONE [GREEN BOOK]

Derris resins

MLS000738056

CHEMBL429023

DTXCID901248

(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-alpha-isopropenyl-8,9-dimethoxy-

(12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano[3,4-b]furano [2,3-h]chroman-6-one

(2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one

(2R-(2alpha,6aalpha,12aalpha))-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)(1)benzopyrano(3,4-b)furo(2,3-h)benzopyran-6(6aH)-one

1,2,12,12aalpha-Tetrahydro-2a-isopropenyl-8,9-dimethoxy(1)benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one

5'beta-Rotenone

Green cross warble

CUBE

(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R-(2alpha,6aalpha,12aalpha))-

(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno(3,4-b)furo(2,3-h)chromen-6-one

(2R-(6aalpha,12aalpha)-1,2-Dihydro-2-isopropenyl-8,9-dimethoxychromano(3,4-b)furo(2,3-h)chroman-6-on

[2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one

NCGC00017358-05

Rotacide

Nekoe

ROTENONE (MART.)

(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-

(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-

Rotenona [Spanish]

Foliafume

Nusyn

Protax

MFCD09025614

5'.beta.-Rotenone

CAS-83-79-4

(2R,6AS,12AS)-1,2,12,12A-TETRAHYDRO-8,9-DIMETHOXY-2-(1-METHYLETHENYL)(1)BENZOPYRANO(3,4-B)FURO(2,3-H)(1)BENZOPYRAN-6(6AH)-ONE

(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

(2R,6aS,12aS)-1,2,6,6a,12,12a- hexahydro-2-isopropenyl-8,9- dimethoxychromeno[3,4-b] furo(2,3-h)chromen-6-one

(2R,6aS,12aS)-2-isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one

(2R,6aS,12aS)-8,9-Dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one

SR-01000076110

Cuberol

Rotenoid

Roteonone

Derri

Sinid

ChemFish

ChemMite

Derris powder

FishTox

DriKil

Cibe Extract

WLN: T G5 D6 B666 CV HO MO POT&TT&J IY1&U1 SO1 TO1

ProNox fish

Fish Tox

PBNox

5''beta-rotenone

5'b-Rotenone

Rotenone commercial

Rotocide E.C.

(1) BENZOPYRANO(3,4-b)FURO(2,3-h)(1)BENZOPYRAN-6(6aH)-ONE, 1, 2, 12, 12a-TETRAHYDRO-8,9-DIMETHOXY-2-(1-METHYLETHENYL)-, (2R,6aS,12aS)-

(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aalphaH)-one, 1,2,12,12aalpha-tetrahydro-2alpha-isopropenyl-8,9-dimethoxy-

(1)BENZOPYRANO(3,4-B)FURO(2,3-H)(1)BENZOPYRAN-6(6AH)-ONE, 1,2,12,12A-TETRAHYDRO-8,9-DIMETHOXY-2-(1-METHYLETHENYL)-, (2R-(2ALPHA,6AALPHA,12A.ALPHA)).-

(1)Benzopyrano[3,3-h](1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-.alpha.-iospropenyl-8,9-dimethoxy-

(12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano(3,4-b)furano (2,3-h)chroman-6-one

(1S,13S)-16,17-dimethoxy-2,7,20-trioxapentacyclo(11.8.0.03,11.04,8.014,19)henicosa-3(11),4(8),9,14,16,18-hexaen-12-one

(1S,13S)-16,17-dimethoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one

(1S,6R,13S)-16,17-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo(11.8.0.03,11.04,8.014,19)henicosa-3(11),4(8),9,14,16,18-hexaen-12-one

(2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno(3,4-b)furo(2,3-h)chromen-6(6aH)-one

(2R-(2alpha,6aalpha,12aalpha))-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)(1)benzopyrano(3,4-b)furo(2,3-H)(1)benzopyran-6(6aH)-one

[1] BENZOPYRANO[3,4-b]FURO[2,3-h][1]BENZOPYRAN-6(6aH)-ONE, 1, 2, 12, 12a-TETRAHYDRO-8,9-DIMETHOXY-2-(1-METHYLETHENYL)-, (2R,6aS,12aS)-

[1]Benzopyrano[3,3-h][1]benzopyran-6(6a.alpha.H)-one, 1,2,12,12a.alpha.-tetrahydro-2.alpha.-isopropenyl-8,9-dimethoxy-

[1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2.alpha.,6a.alpha.,12a.alpha.)]-

[1]BENZOPYRANO[3,4-B]FURO[2,3-H][1]BENZOPYRAN-6(6AALPHAH)-ONE, 1,2,12,12AALPHA-TETRAHYDRO-2ALPHA-ISOPROPENYL-8,9-DIMETHOXY-

[1]BENZOPYRANO[3,4-B]FURO[2,3-H][1]BENZOPYRAN-6(6AH)-ONE, 1,2,12,12A-TETRAHYDRO-8,9-DIMETHOXY-2-(1-METHYLETHENYL)-, [2R-(2ALPHA,6AALPHA,12A.ALPHA]).-

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2alpha,6aalpha,12aalpha)]-

1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methyl-ethenyl)-(1)benzopyrano (3,4-b)furo(2,3-h)(1) benzopyran-6(6aH)-one

1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methyl-ethenyl)-[1]benzopyrano [3,4-b]furo[2,3-h][1] benzopyran-6(6aH)-one

1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

Prestwick_542

Rotenone (7CI)

Rotenone (Standard)

TUBOTOXINE

Rotenone, >=95%

Spectrum_000065

Spectrum2_000457

Spectrum3_000158

Spectrum4_001638

Spectrum5_000455

Rotenone (ACGIH:OSHA)

Lopac0_001112

SCHEMBL42253

BSPBio_001896

isopropenyl(dimethoxy)[?]one

KBioGR_002075

KBioSS_000465

SPECTRUM200013

DivK1c_000947

SPBio_000534

HMS502P09

HY-B1756R

KBio1_000947

KBio2_000465

KBio2_003033

KBio2_005601

KBio3_001116

inhibits NADH2 oxidation to NAD

NSC8505

NINDS_000947

HMS3263O06

(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6a.alpha.H)-one, 1,2,12,12a.alpha.-tetrahydro-2.alpha.-isopropenyl-8,9-dimethoxy-

(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-.alpha.-isopropenyl-8,9-dimethoxy-

(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one,1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-,(2R,6aS,12aS)-

(2R,2.alpha.,6a.alpha.,12a.alpha.)-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6a.alpha.H)-one, 1,2,12,12a.alpha.-tetrahydro-2.alpha.-isopropenyl-8,9-dimethoxy-

2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-H]chromen-6(6ah)-one, (6R,-(6a.alpha.,12a.alpha.)-

BCP07278

HY-B1756

NSC-8505

TNP00301

Tox21_110819

Tox21_201904

Tox21_300695

Tox21_501112

BDBM50135527

CCG-39886

HB5398

LMPK12060007

AKOS004910398

Tox21_110819_1

CS-6067

DB11457

FR65511

LP01112

SDCCGMLS-0066415.P001

SDCCGSBI-0051081.P003

IDI1_000947

Rotenone 100 microg/mL in Acetonitrile

USEPA/OPP Pesticide Code: 071003

NCGC00017358-01

NCGC00017358-02

NCGC00017358-03

NCGC00017358-04

NCGC00017358-06

NCGC00017358-07

NCGC00017358-08

NCGC00017358-09

NCGC00017358-10

NCGC00017358-11

NCGC00017358-14

NCGC00017358-15

NCGC00017358-22

NCGC00094382-01

NCGC00094382-02

NCGC00094382-03

NCGC00094382-04

NCGC00094382-05

NCGC00254603-01

NCGC00259453-01

NCGC00261797-01

AC-31290

AS-10183

DA-77540

NCI60_002093

SMR000393729

EU-0101112

NS00007117

R0090

Rotenone, PESTANAL(R), analytical standard

C07593

R 8875

HYDRO-2-ALPHA-ISOPROPENYL-8,9-DIMETHOXY-

Q412388

SR-01000076110-2

SR-01000076110-5

SR-01000076110-6

BRD-K08316444-001-01-9

BRD-K08316444-001-05-0

1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-

1,2,12,12AALPHA-TETRAHYDRO-2A-ISOPROPENYL-8,9-DIMETHOXY

(1)BENZOPYRANO(3,4-B)FURO(2,3-H)(1)BENZOPYRAN-6(6AH)-ONE, 1,2,12,12A-TETRA-

(1)BENZOPYRANO(3,4-B)FURO(2,3-H)(1)BENZOPYRAN-6(6AH)-ONE, 1,2,12,12A-TETRAHYDRO-8,9-DIMETHOXY-2-(1-METHYLETHENYL)-, (2R-(2ALPHA,6AALPHA, 12AALPHA))-

(1)BENZOPYRANO(3,4-B)FURO(2,3-H)(1)BENZOPYRAN-6(6ALPHAH)-ONE, 1,2,12,12AALPHA-TETRAHYDRO-2ALPHA-ISOPROPENYL-8,9-DIMETHOXY-

(2R,2alpha,6aalpha,12aalpha)-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)(1)benzopyrano(3,4-b)furo(2,3-H)(1)benzopyran-6(6aH)-one

(2R-(6aalpha,12aalpha)-1,2-Dihydro-2-isopropenyl-8,9-dimethoxychromano(3,4-b)furo(2,3-h)chroman-6-one

[1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-.alpha.-isopropenyl-8,9-dimethoxy-

[1]Benzopyrano[3,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2-isopropenyl-8,9-dimethoxy-

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aalphaH)-one, 1,2,12,12aalpha-tetrahydro-2alpha-isopropenyl-8,9-dimethoxy- (8CI)

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)- (9CI)

1,2,12,12A-TETRAHYDRO-2-ALPHA-ISOPROPENYL-8,9-DIMETHOXY(1)BENZOPYRANO-(3,4-B)FURO(2,3-H)(1)BENZOPYRAN-6(6AH)-ONE

1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methyl-ethenyl)-benzopyrano furo benzopyran-6(6aH)-one

1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 9CI

2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno(3,4-b)furo(2,3-H)chromen-6(6ah)-one, (6R,-(6aalpha,12aalpha)-

Tubatoxin 1,2,12,12a,-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]-benzopyran-6(6aH)-one