Vincristine | Solubility of Things

Identification

Molecular formula

C₄₆H₅₆N₄O₁₀

CAS number

57-22-7

IUPAC name

(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

State

At room temperature, vincristine is generally in a solid state. It is not usually encountered in its pure form outside of a laboratory or manufacturing setting, where it's commonly dissolved in solutions for medicinal uses.

Melting point (Celsius)

218.00

Melting point (Kelvin)

491.15

Boiling point (Celsius)

250.00

Boiling point (Kelvin)

523.15

General information

Molecular weight

923.04g/mol

Molar mass

923.0400g/mol

Density

1.2800g/cm³

Appearence

Vincristine appears as a bright, crystalline powder. It is typically white to off-white in color and is usually supplied as a sulfate salt which dissolves readily in water for clinical use.

Comment on solubility

Solubility Comment

The solubility of the compound (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one, with the chemical formula C₄₆H₅₆N₄O₁₀, is influenced by several factors:

Polarity: The presence of multiple functional groups, such as hydroxyl and acetyl, suggests that the compound may exhibit some polar characteristics, which typically enhance solubility in polar solvents like water.
Hydrophobic regions: Conversely, the extensive hydrocarbon backbone and the large number of methyl groups contribute to a more hydrophobic character, possibly making it less soluble in water but more soluble in organic solvents.
Interactions: The interactions between this compound and solvent molecules can significantly affect solubility. For instance, hydrogen bonding from hydroxyl groups may help in solubilizing the compound in polar solvents.

In summary, while the solubility might be favorable in polar organic solvents, one must consider the balance between hydrophobic and hydrophilic characteristics when predicting solubility behavior. Experimental determination would be essential to establish a clearer understanding.

Interesting facts

Interesting Facts about 12,19-Difluoro-11-Hydroxy-8-(2-Hydroxyacetyl)-6,6,9,13-Tetramethyl-5,7-Dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-Dien-16-One

This fascinating compound, often abbreviated for convenience due to its lengthy name, is a member of the class of organic molecules known as complex polycyclic compounds. Here are some intriguing aspects of this chemical:

Stereochemistry: The detailed stereochemical designation in the name indicates several chiral centers. This configuration is crucial because it can significantly influence the compound’s biological activity and properties.
Functional Groups: The presence of hydroxyl (-OH) and acyl (-COCH₃) groups hints at potential reactivity, providing sites for hydrogen bonding and interactions with biological macromolecules.
Fluorination: The incorporation of fluorine in the structure can enhance the stability and lipophilicity of the compound, which is often desirable in pharmaceutical applications. Fluorine atoms can also impact the compound’s metabolic stability.
Structural Complexity: With a pentacyclic system, this compound demonstrates a high degree of structural complexity, which can lead to unique conformational dynamics that are worth exploring in material science and medicinal chemistry.
Potential Biological Activity: While specific studies might be limited, compounds that exhibit similar structural motifs often show promising activity against various biological targets, making them interesting candidates for drug development.

Quote to Ponder: As Louis Pasteur once said, "Chance favors the prepared mind." Each exploration of such intricate compounds prepares scientists for the serendipity of discovery in the realm of chemistry.

This compound stands as a testament to the beauty and intricacy of organic chemistry, heralding the continual interplay between structure and function in the pursuit of new therapeutic agents.

Synonyms

FLUOCINOLONE ACETONIDE

67-73-2

Synalar

Fluonid

Synamol

Synandone

Coriphate

Dermalar

Flucinar

Fluovitif

Flupollon

Percutina

Radiocin

Retisert

Synandrone

Tefunote

Jellin

Localyn

Sinalar

Synemol

Synotic

Synsac

Fluocet

Omniderm

Derma-smoothe/fs

Synalar-HP

Fluotrex

Localyn Syntex

Cortiplastol

Prodermin

Iluvien

Fs Shampoo

Flucort

Capex

Fluocinolonacetonidum

Fluocinolone 16,17-acetonide

Dermatin (steroid)

Acetonide de fluocinolone

Fluzon

6alpha-Fluorotriamcinolone acetonide

Fluocinoloni acetonidum

RS-1401 AT

Oto-synalar

Acetonida de fluocinolona

Fluocinolone (Acetonide)

RS 1401AT

Flucinolone acetonide

Fluocinoloni acetonidum [INN-Latin]

NSC-92339

Fluocinolide (acetate)

CCRIS 3250

Dermotic

6alpha,9alpha-Difluoro-16alpha-hydroxyprednisolone 16,17-acetonide

acetonido de fluocinolona

component of Neo-Synalar

HSDB 3083

UNII-0CD5FD6S2M

EINECS 200-668-5

0CD5FD6S2M

NSC 92339

Acetonide de fluocinolone [INN-French]

YUTIQ

Acetonida de fluocinolona [INN-Spanish]

DTXSID0040674

CHEBI:31623

Fluocinolone acetonide (Flucort-N)

NSC92339

MFCD00010525

6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone

6-alpha,9-alpha-Difluoro-16-alpha-hydroxyprednisolone 16,17-acetonide

Fluocinolone acetonide intravitreal implant

MLS000028545

MLS001076276

Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-

Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone

DTXCID8020674

Fluzon (Steroid)

Fluzon [Steroid]

SMR000058329

Fluocinolone acetonide [USAN:USP:INN:JAN]

OTOVEL COMPONENT FLUOCINOLONE ACETONIDE

Fluocinolone acetonide [DCIT]

ILUVIEN COMPONENT FLUOCINOLONE ACETONIDE

TRI-LUMA COMPONENT FLUOCINOLONE ACETONIDE

(6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

NEO-SYNALAR COMPONENT FLUOCINOLONE ACETONIDE

Fluortriamcinolone Acetonide

Fluocinoloni acetonidum (INN-Latin)

FLUOCINOLONE ACETONIDE (MART.)

FLUOCINOLONE ACETONIDE [MART.]

6.alpha.-Fluorotriamcinolone acetonide

FLUOCINOLONE ACETONIDE (USP-RS)

FLUOCINOLONE ACETONIDE [USP-RS]

Acetonide de fluocinolone (INN-French)

CAS-67-73-2

Acetonida de fluocinolona (INN-Spanish)

Retisert (TN)

(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one

Fluocet (TN)

Synalar (TN)

FLUOCINOLONE ACETONIDE (EP MONOGRAPH)

Fluocinolone acetonide (USAN:USP:INN:JAN)

FLUOCINOLONE ACETONIDE (USP IMPURITY)

FLUOCINOLONE ACETONIDE [EP MONOGRAPH]

FLUOCINOLONE ACETONIDE [USP IMPURITY]

FLUOCINOLONE ACETONIDE (USP MONOGRAPH)

FLUOCINOLONE ACETONIDE [USP MONOGRAPH]

Acetonide, Fluocinolone

6.Alpha.,9-Difluoro

Acetonide, Fluortriamcinolone

Synalar Ts

Flucort-N

Flac Otic Oil

NCGC00021301-04

(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho(2',1':4,5)indeno(1,2-d)(1,3)dioxol-2-one

(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione

(6alpha,9alpha,11beta,16beta)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Fluocinolon acetonid

Fluocinolone acetonide; 6a,9-Difluoro-11ss,21-dihydroxy-16a,17-(1-methylethylidenedioxy)pregna-1,4-diene-3,20-dione

FLAC

fluocinolone-acetonide

XILAPAK

fluocinolone (alcohol)

Fluocinolone AcetonideOil

Synalar Cream Veterinary

6.alpha.,17-acetonide

Opera_ID_1295

F0657

CHEMBL989

Synalar Solution Veterinary

SCHEMBL4795

FLUOCINONIDE ACETONIDE

6alpha,9alpha-Difluoro-11beta,16alpha,17alpha,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-Acetonide

Fluocinolone Acetonide Topical

Fluocinolone Acetonide 0.01%

GTPL7077

6?-Fluorotriamcinolone acetonide

HY-B0415R

C05AA10

D07AC04

S01BA15

S02BA08

HMS2090I14

HMS2230D13

HMS3259G12

HMS3715J11

FLUOCINOLONE ACETONIDE [MI]

HY-B0415

Fluocinolone (Acetonide) (Standard)

FLUOCINOLONE ACETONIDE [INN]

FLUOCINOLONE ACETONIDE [JAN]

Tox21_110869

Tox21_302364

AC-429

AC1069

FLUOCINOLONE ACETONIDE [HSDB]

FLUOCINOLONE ACETONIDE [USAN]

s2470

FLUOCINOLONE ACETONIDE [VANDF]

AKOS015963144

Tox21_110869_1

CCG-221165

DB00591

FF15770

FLUOCINOLONE ACETONIDE [WHO-DD]

NC00562

Fluocinolone acetonide (JP17/USP/INN)

NCGC00021301-06

NCGC00255654-01

(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

AS-13690

NCI60_042042

Fluocinolone Acetonide (anti-inflammatory)

FLUOCINOLONE ACETONIDE [GREEN BOOK]

Fluocinolone acetonide, analytical standard

FLUOCINOLONE ACETONIDE [ORANGE BOOK]

Fluocinolone acetonide for system suitability

NS00008944

D01825

AB00383017-10

AB00383017_11

EN300-7410632

FLUOCINOLONE ACETONIDE COMPONENT OF OTOVEL

Fluocinolone Acetonide Oil, 0.01% (Ear Drops)

OTOVEL COMPONENT OF FLUOCINOLONE ACETONIDE

A853087

FLUOCINOLONE ACETONIDE COMPONENT OF ILUVIEN

Q924467

SR-01000000109

FLUOCINOLONE ACETONIDE COMPONENT OF TRI-LUMA

Fluocinolone Acetonide Topical Solution USP, 0.01%

SR-01000000109-2

BRD-K94353609-001-21-6

difluoro-hydroxy-(2-hydroxyacetyl)-tetramethyl-[?]one

FLUOCINOLONE ACETONIDE COMPONENT OF NEO-SYNALAR

6.alpha., 9.alpha.-Difluoro-16.alpha.-hydroxyprednisolone 16,17-acetonide

Fluocinolone acetonide, European Pharmacopoeia (EP) Reference Standard

Fluocinolone acetonide, United States Pharmacopeia (USP) Reference Standard

Fluocinolone acetonide for system suitability, European Pharmacopoeia (EP) Reference Standard

Fluocinolone Acetonide, Pharmaceutical Secondary Standard; Certified Reference Material

WLN: T F5 E5 B666 GO IO RV AHTTTT&J A BF CQ E FVIQ H H OF -A&BHO -B&ACEF

(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

(6a,11b,16a)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione

200-668-5

6.alpha.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone

6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(1-methylethylidenedioxy)pregna-1,4-diene-3,20-dione

Fluocinolone acetonide for peak identification, European Pharmacopoeia (EP) Reference Standard

Pregna-1,20-dione, 6,9-difluoro-11,12-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6.alpha.,11.beta.,16.alpha.)-

Pregna-1,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)-, (6.alpha.,11.beta.,16.alpha.)-

Pregna-1,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6.alpha.,11.beta.,16.alpha.)-

Pregna-1,20-dione, 6.alpha.,9-difluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone

PREGNA-1,4-DIENE-3,20-DIONE, 6,9-DIFLUORO-11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (6.ALPHA.,11.BETA.,16.ALPHA.)-