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Pyrazole

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Identification
Molecular formula
C3H4N2
CAS number
288-13-1
IUPAC name
1H-pyrazole
State
State

At room temperature, pyrazole is typically found in a solid state. It is stable under normal conditions but should be kept out of extreme temperatures to maintain its integrity.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.10
Boiling point (Celsius)
187.50
Boiling point (Kelvin)
460.60
General information
Molecular weight
68.08g/mol
Molar mass
68.0770g/mol
Density
1.1660g/cm3
Appearence

Pyrazole is a colorless or pale yellow crystalline solid. The compound is often found in a crystalline powder form when isolated.

Comment on solubility

Solubility of 1H-pyrazole (C3H4N2)

1H-pyrazole, identified by its chemical formula C3H4N2, exhibits a moderate level of solubility in various solvents, which is paramount for its applications in chemical synthesis and analytical chemistry.

  • Water: 1H-pyrazole demonstrates limited solubility in water, typically due to its non-polar character, which makes it less favorable for interactions with polar solvent molecules.
  • Organic Solvents: It is more soluble in organic solvents such as ethanol, methanol, and acetone. This affinity can be attributed to the compatibility of its molecular structure with these non-polar or weakly polar solvents.
  • Temperature Dependency: The solubility can vary with temperature; increasing temperature generally enhances solute interactions, leading to better solubility in organic mediums.

As noted in various studies, the solubility of 1H-pyrazole can significantly affect its reactivity and utility in chemical processes. Hence, careful consideration of solvent choice and conditions is essential. To quote an authoritative source, "The solubility of a compound is a critical factor in determining its applicability in synthetic routes."

In summary, understanding the solubility properties of 1H-pyrazole is essential for its effective utilization in research and industrial settings.

Interesting facts

Interesting Facts about 1H-Pyrazole

1H-pyrazole is an organic compound that is defined by its unique five-membered ring structure containing two nitrogen atoms. This compound has gained attention in various fields of research and applications due to its remarkable properties. Here are some fascinating aspects of 1H-pyrazole:

  • Versatile Intermediary: 1H-pyrazole is widely used as a building block in organic synthesis. It serves as a precursor for a variety of derivatives that have potential applications in pharmaceuticals and agrochemicals.
  • Biological Activity: Many derivatives of 1H-pyrazole exhibit significant biological activities, such as anti-inflammatory, antimicrobial, and anticancer properties. Research has shown that certain compounds derived from 1H-pyrazole can inhibit specific enzymes, making them of great interest in drug design.
  • Material Science: The unique properties of 1H-pyrazole allow it to function as a ligand in coordination chemistry, wherein it can form complexes with various metals, paving the way for advancements in materials science.
  • Exploration of Reactivity: The reactivity of 1H-pyrazole towards electrophiles and nucleophiles opens up pathways for the development of new synthetic methodologies. This makes it a valuable tool in the hands of organic chemists.
  • Impact in Agriculture: Compounds derived from 1H-pyrazole have been explored for their potential as agrochemicals, particularly as herbicides and fungicides, showcasing its significance beyond just the pharmaceutical realm.

In conclusion, 1H-pyrazole is not just a simple organic compound; it is a key player in various scientific fields, from medicinal chemistry to material science. As researchers continue to explore its properties and applications, the potential of 1H-pyrazole could lead to the development of novel compounds that address critical challenges in health, agriculture, and beyond.

Synonyms
pyrazole
1H-Pyrazole
288-13-1
1,2-diazole
Pyrazol
1H-pyrazol
UNII-3QD5KJZ7ZJ
3QD5KJZ7ZJ
EINECS 206-017-1
MFCD00005234
NSC 45410
CHEBI:17241
AI3-60151
NSC45410
NSC-45410
DTXSID2059774
EC 206-017-1
Hpz
diazole
Pyrazole; 1H-Pyrazole; 1,2-Diazole; 2-Azapyrrole; NSC 45410
Pyrazole-
3-pyrazole
Pyrazole, 98%
PYRAZOLE [MI]
WLN: T5MNJ
CHEMBL15967
DTXCID4037873
BCP26863
STR00103
BDBM50390969
s3093
STK400566
AKOS000121045
Pyrazole, purum, >=98.0% (GC)
CS-W008829
DB02757
FP15855
BP-12835
HY-76228
NCI60_004054
Pyrazole, Vetec(TM) reagent grade, 98%
NS00014209
P0546
EN300-21658
A15455
C00481
D78528
AC-907/25014006
Q408908
F2190-0642
Z104507728
InChI=1/C3H4N2/c1-2-4-5-3-1/h1-3H,(H,4,5
105809-46-9
206-017-1