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Triamcinolone

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Identification
Molecular formula
C21H27FO6
CAS number
124-94-7
IUPAC name
19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
State
State

At room temperature, Triamcinolone is in a solid state, usually in a crystalline powder form.

Melting point (Celsius)
283.50
Melting point (Kelvin)
556.65
Boiling point (Celsius)
330.80
Boiling point (Kelvin)
603.95
General information
Molecular weight
394.45g/mol
Molar mass
394.4500g/mol
Density
1.4200g/cm3
Appearence

Triamcinolone appears as white to practically white, crystalline powder. It is odorless or has a slight odor.

Comment on solubility

Solubility of 19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one

The solubility of the compound with the formula C21H27FO6 is influenced by several factors:

  • Molecular Structure: The presence of hydrophilic functional groups such as hydroxyl (–OH) and acetyl (–COCH3) can enhance solubility in polar solvents like water.
  • Hydrophobic Regions: Conversely, the extensive hydrophobic regions due to the multiple cycloalkane structures may limit solubility in water, promoting solubility in non-polar solvents.
  • Polarity: The overall polarity of the molecule plays a crucial role; compounds with a balance of hydrophilic and hydrophobic characteristics typically exhibit amphiphilic behavior, leading to solubility in both polar and non-polar environments.

In terms of solubility, it is often stated that "like dissolves like." Therefore:

  • In water (polar solvent), the solubility may be moderate due to the polar functional groups.
  • In organic solvents (non-polar solvent), such as hexane or toluene, solubility is likely to be higher due to the hydrophobic character of the compound.

Ultimately, the specific solubility behavior can be assessed through experimentation, considering factors like temperature, pH, and the presence of other solvents or solutes, which can significantly alter the interaction dynamics and solubility profile of this complex molecule.

Interesting facts

Exploring 19-Fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one

This particularly complex compound represents an intricate structure within the realm of organic chemistry, showcasing a variety of functional groups and stereochemistry that are pivotal to its reactivity and properties. Here are some compelling facts about this fascinating molecule:

  • Fluorine's Role: The presence of fluorine in this compound often enhances chemical stability and can affect biological activity, making it an important element in pharmaceuticals and agrochemicals.
  • Hydroxyl Groups: The two hydroxyl (-OH) groups not only contribute to potential hydrogen bonding interactions but also play a crucial role in solubility and reactivity patterns.
  • Complex Core Structure: The pentacyclic structure reflects the compound's sophistication and often indicates a rich tapestry of interactions, both intra- and intermolecular.
  • Potential Applications: Due to its structural characteristics, this compound could serve as a *template* for designing new therapeutics, especially targeting specific biological pathways.

As we delve further into the intricacies of such compounds, we are reminded of the words of chemistry visionary Linus Pauling: "The best way to have a good idea is to have lots of ideas." The exploration of compounds like this not only expands our understanding of chemistry but also fuels innovations in drug design and materials science.

In summary, 19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one is more than just a complex name; it symbolizes the beauty and complexity of chemical research.

Synonyms
Fluoroandrenolone acetonide
Fludroxycortida
SCHEMBL13423594
DTXSID60859657
POPFMWWJOGLOIF-UHFFFAOYSA-N
Pregn-4-ene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6.alpha.,11.beta.,16.alpha.)-
(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9.0^{4,8.0^{13,18]icos-17-en-16-one
(6.alpha.,11.beta.)-6-Fluoro-11,21-dihydroxy-16.alpha.,17.alpha.-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
12-Fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
12-Fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one #
6.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with acetone
Pregn-4-ene-3,20-dione, 6.alpha.-fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone