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Epothilone A

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Identification
Molecular formula
C26H39NO6
CAS number
152044-54-7
IUPAC name
18-hydroxy-10,10,16,17-tetramethyl-6-propyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaen-4-one
State
State

At room temperature, Epothilone A is a solid compound.

Melting point (Celsius)
41.00
Melting point (Kelvin)
314.15
Boiling point (Celsius)
80.00
Boiling point (Kelvin)
353.15
General information
Molecular weight
493.60g/mol
Molar mass
493.6770g/mol
Density
1.2400g/cm3
Appearence

Epothilone A is typically a pale yellow to off-white solid powder. It may appear as a crystalline substance depending on its level of purity.

Comment on solubility

Solubility of 18-hydroxy-10,10,16,17-tetramethyl-6-propyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaen-4-one (C26H39NO6)

The solubility of a compound is a vital characteristic that plays a significant role in its chemical behavior and practical applications. For 18-hydroxy-10,10,16,17-tetramethyl-6-propyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaen-4-one, the solubility can be assessed based on several factors:

  • Polarity: The presence of multiple functional groups, including hydroxyl (–OH) and ether (–O–) links, suggests that this compound may exhibit varying degrees of polarity. This polarity can influence its solubility in polar solvents such as water versus nonpolar solvents like hexane.
  • Molecular Weight: With a molecular formula of C26H39NO6, the relatively high molecular weight may limit solubility due to decreased interaction with solvent molecules.
  • Hydrogen Bonding: The hydroxyl group can engage in hydrogen bonding, which can enhance solubility in polar solvents but may also lead to complex solubility profiles.
  • Structural Dynamics: The intricate structure, featuring multiple rings and functional groups, may result in steric hindrance, affecting how well the compound can interact with solvents.

In general, compounds with increased polarity and the ability to form hydrogen bonds tend to have better solubility in polar solvents, while larger, more complex structures may facilitate solubility in organic solvents. However, the specific solubility of this compound would require experimental data for definitive conclusions.


As the saying goes, "Chemistry is the study of matter, but I prefer to view it as the study of change," and understanding solubility is a fundamental part of this ever-changing landscape. Exploring the solubility of this compound could unveil valuable insights into its potential uses in various chemical processes.

Interesting facts

Interesting Facts about 18-Hydroxy-10,10,16,17-tetramethyl-6-propyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaen-4-one

This complex compound may seem daunting at first glance due to its lengthy name, but it is intriguing for several reasons:

  • Structural Complexity: The compound features a unique tetracyclic structure, showcasing the fascinating diversity in organic chemistry. The multiple functional groups and stereocenters lead to a rich variety of chemical behaviors and potential reactivity.
  • Natural Occurrence: Compounds with similar structures are often found in nature. They might be closely related to natural products that have biological significance, which could lead to interesting pharmaceutical applications.
  • Applications: Compounds of this nature can serve multiple purposes, such as being used in the synthesis of drugs or as intermediates in various chemical reactions. Their structural properties may allow them to interact with biological systems effectively.
  • Research Potential: The chemical properties and interactions of such compounds make them a point of interest in organic synthesis and medicinal chemistry. Studying their reactivity could yield valuable insights into chemical behavior in complex environments.
  • Environmental Impact: Exploring compounds like this can help scientists assess their potential environmental effects, as many complex organic molecules can have significant ecological roles or consequences.

As one researcher noted, "The intricate dance of electrons within these multifaceted structures unveils the hidden secrets of chemistry.' This encapsulates the thrill of delving into a compound like this—where every bond and molecular twist holds the key to new discoveries.

In summary, this compound is not just a collection of atoms; it opens a doorway to the realms of synthetic chemistry, ecological sustainability, and potential therapeutic strategies, reminding chemists of the endless possibilities that complex organic compounds present.

Synonyms
Calanolide
MLS000756699
NSC664737
NSC-650886
CHEMBL270362
NIDRYBLTWYFCFV-UHFFFAOYSA-N
NCGC00246860-01
SMR000529105
2,3,4,10,10-Pentamethyl-6-methylene-8-propyl-1,2,3,4,5,6,9,10-octahydro-triphenylene
18-hydroxy-10,10,16,17-tetramethyl-6-propyl-3,9,15-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11-pentaen-4-one