Skip to main content

Betamethasone

ADVERTISEMENT
Identification
Molecular formula
C22H29FO5
CAS number
378-44-9
IUPAC name
(17-hydroxy-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-yl)methyl acetate
State
State

At room temperature, betamethasone is in a solid state, appearing as a crystalline powder. It is stable under normal conditions of use.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
392.46g/mol
Molar mass
392.4660g/mol
Density
1.2700g/cm3
Appearence

Betamethasone appears as a white to off-white crystalline powder that is typically odorless. It is practically insoluble in water, sparingly soluble in acetone and in alcohol, and slightly soluble in chloroform.

Comment on solubility

Solubility of 17-hydroxy-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-yl)methyl acetate

The solubility of this complex compound, identified by its chemical formula C22H29FO5, introduces an intriguing aspect of its chemical behavior. When discussing solubility, it is essential to consider several factors that influence how well a compound dissolves:

  • Polarity: The presence of various functional groups, such as hydroxyl and ester, suggests that the compound may exhibit both polar and non-polar characteristics. This dual nature can affect its solubility in different solvents.
  • Solvent Interaction: This compound may be more soluble in polar solvents like ethanol or methanol due to hydrogen bonding with the hydroxyl group, while non-polar solvents may be less effective.
  • Temperature Effects: Generally, increasing temperature can enhance solubility, particularly for solids in liquids; however, the specific solubility behavior might vary based on the compound's characteristics.

As a rule of thumb, it is often stated that “like dissolves like,” meaning that polar compounds are soluble in polar solvents, and non-polar compounds in non-polar solvents. Therefore, for this compound, one might want to explore:

  • The solubility in aqueous environments to gauge any pharmacological relevance,
  • The possibility of micelle formation in non-polar solvents, and
  • Any temperature thresholds that significantly alter its solubility profile.

In conclusion, the solubility behavior of this compound is likely multifaceted, influenced by structural features and environmental conditions. Further experimental investigation can yield valuable insights into its practical applications.

Interesting facts

Interesting Facts about 17-hydroxy-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-yl)methyl acetate

This compound is a fascinating example of a complex organic molecule that belongs to the family of natural products. Its intricate structure showcases the power of organic chemistry in creating diverse compounds with unique properties and potential applications.

Key Highlights:

  • Structural Complexity: The pentacyclic structure consisting of multiple fused rings can serve as a great topic for studying structural isomerism and the effects of ring size on stability and reactivity.
  • Biological Significance: Compounds like this one are often of interest in medicinal chemistry due to their potential bioactivity, which might include anti-inflammatory or antioxidant properties.
  • Synthetic Challenges: The synthesis of such a complex molecule is a testament to the advancements in synthetic organic chemistry, often involving multiple steps and strategic planning to achieve the desired structure.
  • Applications: This compound, due to its acetate moiety, may have applications in drug development or as a precursor in a synthetic pathway for creating other bioactive compounds.

As noted by many chemists, "The beauty of chemistry lies not only in the reactions and interactions but also in the elegance of molecular design." The study of compounds such as this one, with their multifaceted resources and bioactivities, not only enhances our understanding of chemical principles but also contributes significant insights into potential therapeutic agents.

This compound represents a small yet significant piece of the vast puzzle that is organic chemistry, demonstrating the intricate connections between molecular architecture and functional characteristics across various fields of research.

Synonyms
CAFESTOL ACETATE
81760-48-7
(17-Hydroxy-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-yl)methyl acetate
5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol,3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, 7-acetate,(3bS,5aS,7R,8R,10aR,10bS)-
(7-hydroxy-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-yl)methyl acetate
CAFESTOLACETATE
Cafesterol acetate
Cafestol acetate, >=98%
MLS002695892
CHEMBL1888231
SMR001562096