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Ethinyl Estradiol

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Identification
Molecular formula
C20H24O2
CAS number
57-63-6
IUPAC name
17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

Ethinyl estradiol is a solid at room temperature and is typically found in powdered form for pharmaceutical applications.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
570.25
Boiling point (Kelvin)
843.40
General information
Molecular weight
296.40g/mol
Molar mass
296.4030g/mol
Density
1.2150g/cm3
Appearence

Ethinyl estradiol appears as a white to practically white crystalline powder. It is typically odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of the compound 17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one (C20H24O2) can be characterized as follows:

  • Solvent Dependence: This compound is generally more soluble in organic solvents such as ethanol, methanol, and chloroform.
  • Polar vs. Non-Polar Solvents: It tends to have low solubility in highly polar solvents (e.g., water) due to a significant hydrophobic character attributed to its extensive hydrocarbon structure.
  • Temperature Influence: Increased temperature may enhance solubility in organic solvents by disrupting intermolecular interactions.
  • pH Sensitivity: The solubility might also vary with changes in pH, as functional groups susceptible to ionization could affect solubility in aqueous environments.

In summary, while the compound shows promising solubility in general organic solvents, its hydrophobic nature limits its solubility in polar solvents, making its applications in aqueous systems somewhat challenging. As a result, understanding the solubility profile is crucial for further applications and studies involving this compound.

Interesting facts

Interesting Facts About 17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This compound belongs to the class of steroids, and its structural complexity provides intriguing insights into its properties and potential applications. Here are some notable facts:

  • Steroid Nature: As a modified steroid, it features unique functional groups that influence its biological activity.
  • Potential Uses: Compounds like this are often researched for their potential pharmaceutical applications, including hormonal therapies and anti-cancer treatments.
  • Synthesis: The synthetic pathways to create such specific compounds often involve intricate multi-step reactions, showcasing the elegance and complexity of organic chemistry.
  • Biological Impact: Modifications such as ethynyl and hydroxyl groups can significantly alter how the compound interacts with biological systems, increasing potency or changing the mechanism of action.
  • Research Interest: The study of such compounds is essential in medicinal chemistry, as researchers aim to discover new drugs with improved efficacy and fewer side effects.

In conclusion, 17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one embodies the profound link between organic chemistry and biological functions. Its intricate structure not only represents a remarkable achievement in synthetic chemistry but also holds promise for advancements in medical science.

Synonyms
Minovlar
(17beta)-17-ethynyl-17-hydroxyestr-4-en-3-one
17.alpha.-Ethinyl-19-nortestosterone
17.alpha.-Ethynyl-19-nortestosterone
19-Nor-17.alpha.-ethynyltestosterone
Nor-Q.D.
17.alpha.-Ethynyl-4-estren-17-ol-3-one
17.alpha.-Ethynyl-17-hydroxy-4-estren-3-one
17.alpha.-Ethinylestra-4-en-17.beta.-ol-3-one
17.beta.-Hydroxy-19-norpregn-4-en-20-yn-3-one
Estr-4-en-3-one, 17.alpha.-ethynyl-17-hydroxy-
17.alpha.-Ethynyl-17.beta.-hydroxyestr-4-en-3-one
17-Hydroxy-19-nor-17.alpha.-pregn-4-en-20-yn-3-one
19-nor-17.alpha.-Ethynylandrosten-17.beta.-ol-3-one
17.alpha.-Ethynyl-19-nor-4-androsten-17.beta.-ol-3-one
17.alpha.-Ethynyl-19-norandrost-4-en-17.beta.-ol-3-one
19-Nor-17.alpha.-pregn-4-en-20-yn-3-one, 17-hydroxy-
17.alpha.-Ethynyl-17.beta.-hydroxy-19-norandrost-4-en-3-one
19-nor-17.alpha.-Ethynyl-17.beta.-hydroxy-4-androsten-3-one
17.alpha.-Ethinyl-17.beta.-hydroxy-.delta.(sup:4)-estren-3-one
component of Noriday
Oprea1_606355
19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-, (17.alpha.)-
SCHEMBL5021649
CHEMBL4579631
DTXSID60859071
VIKNJXKGJWUCNN-UHFFFAOYSA-N
BBL012124
STK730956
AKOS005524503
AKOS037478319
NCGC00263506-02
17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
AB01325874-02
WLN: L E5 B666 OV MUTJ E FQ F1UU1 -A&F
1aEthynyla1ahydroxya11aamethyla1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aHacyclopenta[a]phenanthrena7aone