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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
State
State

At room temperature, estrone is a solid.

Melting point (Celsius)
259.00
Melting point (Kelvin)
532.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
270.37g/mol
Molar mass
270.3680g/mol
Density
1.2300g/cm3
Appearence

Estrone appears as colorless crystals.

Comment on solubility

Solubility of 17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol (C18H22O2)

The solubility of the compound 17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol can be influenced by several factors, including its unique structural properties and the functional groups present. Understanding its solubility characteristics is crucial for various applications in chemistry and related fields. Here are some key points regarding its solubility:

  • Polarity: As a phenolic compound, it has a hydroxyl (-OH) group that enhances its ability to dissolve in polar solvents.
  • Hydrophobic nature: The hydrocarbon structure contributes to hydrophobic interactions; thus, it may also show a certain degree of solubility in nonpolar solvents.
  • Common solvents: It is likely to be soluble in organic solvents such as ethanol and methanol, but less so in water due to its larger hydrophobic hydrocarbon portion.

Moreover, it is important to note that the compound's solubility will vary based on conditions like temperature and pressure, which can significantly affect molecular interactions. As a general rule, compounds with larger hydrophobic components tend to have lower solubility in polar solvents. Therefore, one might observe that:

  1. If dissolved in polar solvents, it may exhibit limited solubility.
  2. In nonpolar solvents, however, it might achieve much higher solubility.

Understanding the solubility of this compound is essential for its practical applications and reactivity in chemical processes.

Interesting facts

Facts About 17-Ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

This compound is notably recognized for its structure and complexity, embodying a rich tapestry of organic chemistry. Here are some fascinating aspects:

  • Unique Structure: The molecular architecture of this compound showcases a polycyclic system, which plays a significant role in various biological activities and chemical interactions.
  • Biological Significance: Compounds of this structural family have been studied for their potential applications in pharmacology, particularly in the realm of hormone-related research.
  • Natural Occurrence: Its cyclic nature is often seen in numerous natural products and plays a significant role in the behavior of different steroids and terpenes, highlighting a connection between natural compounds and synthetic chemistry.
  • Research Applications: This compound serves as a scaffold in designing new drugs, particularly in developing treatments related to hormonal imbalances due to its ability to mimic natural hormones.
  • Synthesis Challenges: Synthesizing such complex molecules can be a daunting task, often necessitating advanced techniques in organic synthesis, including multi-step reactions and the use of protective groups.
  • Analytical Techniques: Characterizing this compound generally employs sophisticated analytical techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography, allowing chemists to unveil its intricate structure.

In the words of renowned chemist Robert H. Grubbs, “Designing molecules is like painting, where the canvas is the chemistry itself.” Understanding compounds like 17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol is akin to mastering the art of molecular innovation – a journey filled with both challenges and triumphs.

Ultimately, this compound not only exemplifies the beauty of organic chemistry but also portrays the intricate balance between nature and synthetic life, making it a significant topic of study for students and scientists alike.

Synonyms
ORG-483
19-Nor-17.alpha.-pregn-4-en-17-ol
19-Norpregn-4-en-17-ol, (17.alpha.)-
Estr-4-en-17.beta.-ol, 17-ethyl-
19-Norpregn-4-en-17-ol
DTXSID40859559
NSC37726
19-Nor-17.alpha.-pregn-4-en-17.beta.-ol