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Fluocinolone acetonide

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Identification
Molecular formula
C24H30ClFO6
CAS number
356-12-7
IUPAC name
[17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate
State
State

At room temperature, fluocinolone acetonide is a solid compound. It is stable under normal conditions and does not readily decompose or react with air.

Melting point (Celsius)
274.00
Melting point (Kelvin)
547.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
452.50g/mol
Molar mass
452.4990g/mol
Density
1.1950g/cm3
Appearence

Fluocinolone acetonide is typically a white to off-white crystalline powder. It is often odorless and has a fine, particle consistency. Due to its low solubility in water, it is frequently used in topical formulations rather than in solution.

Comment on solubility

Solubility of the Compound

The solubility of the compound 17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl butanoate (C24H30ClFO6) is influenced by its complex structure and functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of the chlorine atom and fluorine atom may contribute to the compound's overall polarity, potentially enhancing its solubility in polar solvents.
  • Functional Groups: The ester functionality (butanoate) typically exhibits good solubility in organic solvents such as ethanol or acetone, while the dioxo groups may affect solubility differently based on pH and solvent type.
  • Solvent Compatibility: This compound is likely soluble in organic solvents but may have limited solubility in water due to its larger hydrophobic regions.
  • Temperature Effects: Solubility might increase with temperature; hence, determining the exact solubility may require testing at different thermal conditions.

In summary, while the exact solubility values for this compound in various solvents are not readily available, its unique combination of chemical groups suggests a solubility profile akin to that of moderately polar organic compounds. Further experimental investigation would be necessary to obtain precise solubility data.

Interesting facts

Interesting Facts about 17-(2-Chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl Butanoate

This fascinating compound, often referred to in the realm of medicinal chemistry, is a derivative of a steroid scaffold, showcasing the intricate relationship between structure and biological activity.

Key Highlights:

  • Chemical Diversity: The presence of chlorine in the side chain suggests that this compound may exhibit unique reactivity patterns and biological activities, particularly in pharmaceutical contexts.
  • Fluorine Influence: The incorporation of fluorine is notable as it often enhances the metabolic stability of organic compounds, making them more effective drugs.
  • Synthetic Challenges: The synthesis of such a complex molecule involves elaborate multi-step synthetic pathways, demonstrating the power of organic synthesis in drug development.
  • Potential Applications: Compounds like this one are typically investigated for their antitumor properties, showcasing the intersection of chemistry and medicinal science.

One might ponder the implications of such complex biological interactions, where scientists quote, "The structure of a compound is often a reflection of its function in biological systems." Consequently, this compound presents a rich field for exploration, merging elements of design, synthesis, and application in therapeutic scenarios. It embodies the ongoing quest in chemistry to craft molecules that can function as both tools and targets in the fight against diseases.

In conclusion, the study of 17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl butanoate illustrates the extraordinary capabilities of modern chemistry to innovate and discover, paving the way for future advancements in medical science.

Synonyms
Clobetasonebutyrate
SCHEMBL448850
16?-Methyl clobetasone butyrate
DTXSID30860331
ABA12098
AKOS024366241
21-chloro-9-fluoro-16-methyl-3,11,20-trioxopregna-1,4-dien-17-yl butanoate