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15-Hydroxyeicosatetraenoic acid (15-HETE)

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Identification
Molecular formula
C20H32O3
CAS number
74144-12-0
IUPAC name
15-hydroxyicosa-5,8,11,13,17-pentaenoic acid
State
State

At room temperature, 15-Hydroxyicosatetraenoic acid is typically a liquid with a slightly viscous consistency.

Melting point (Celsius)
60.00
Melting point (Kelvin)
333.15
Boiling point (Celsius)
658.15
Boiling point (Kelvin)
931.30
General information
Molecular weight
320.48g/mol
Molar mass
320.4880g/mol
Density
0.9400g/cm3
Appearence

15-Hydroxyicosa-5,8,11,13,17-pentaenoic acid, commonly known as 15-Hydroxyicosatetraenoic acid (15-HETE), typically appears as a viscous, colorless to pale yellow oily liquid. It is soluble in organic solvents like ethanol and DMSO but insoluble in water.

Comment on solubility

Solubility of 15-hydroxyicosa-5,8,11,13,17-pentaenoic acid

15-hydroxyicosa-5,8,11,13,17-pentaenoic acid, with the chemical formula C20H32O3, displays interesting solubility characteristics that are worth noting:

  • Polar Nature: Due to the presence of a hydroxyl (–OH) group in its structure, this compound exhibits polar characteristics, which can influence its solubility in various solvents.
  • Solvent Compatibility: It is generally soluble in organic solvents such as ethanol and methanol, which are polar in nature, making it easier for the molecule to interact and dissolve.
  • Limited Water Solubility: While it has some polar features, the overall hydrocarbon chain length leads to poor solubility in water, indicating that water is not an ideal solvent for this compound.

In summary, the solubility of 15-hydroxyicosa-5,8,11,13,17-pentaenoic acid is dependent on its molecular structure, influencing its interaction with various solvents. The presence of hydrophilic –OH groups alongside hydrophobic hydrocarbon chain segments creates a complex behavior in solubilization processes, making the understanding of its solubility essential for applications in biochemical and pharmaceutical contexts.

Interesting facts

Fascinating Insights into 15-Hydroxyicosa-5,8,11,13,17-pentaenoic Acid

15-hydroxyicosa-5,8,11,13,17-pentaenoic acid, commonly referred to as 15-Hydroxyeicosatrienoic acid (15-HETrE), is a fascinating compound that plays a significant role in various biological processes. Here are some key facts and insights about this intriguing fatty acid:

  • Biological Significance: This compound is a bioactive lipid that is involved in the regulation of numerous physiological functions, particularly in the cardiovascular system. Its role in modulating inflammatory responses has garnered substantial interest in the field of pharmacology.
  • Molecular Interaction: 15-HETrE is known to interact with various receptors, which can lead to vasodilation and have protective effects on blood vessels. This highlights its potential as a therapeutic target in treating cardiovascular diseases.
  • Source: It is derived from essential fatty acids, particularly arachidonic acid, which is an important building block in the human diet. The synthesis of 15-HETrE occurs through enzymatic processes, demonstrating a complex interplay within metabolic pathways.
  • Research Focus: Current research is ongoing to understand the full range of its biological activities. Scientists are particularly interested in its potential neuroprotective effects and its applications in managing conditions related to inflammation.

As quoted in research, scientists are excited about the "potential of 15-Hydroxyeicosatrienoic acid to revolutionize our understanding of lipid mediators in inflammatory mechanisms." This quote reflects the compound's growing importance in the medical field and highlights the ongoing exploration of its therapeutic applications.

Overall, 15-hydroxyicosa-5,8,11,13,17-pentaenoic acid is more than just a fatty acid; it represents a critical component of our biological systems and a promising avenue for future research and therapeutic interventions.

Synonyms
15-Hydroxy-5,8,11,13,17-eicosapentaenoic acid
97850-14-1
DTXSID40904331
(+/-)15-HEPE
5,8,11,13,17-Eicosapentaenoic acid, 15-hydroxy-
15-hydroxyicosa-5,8,11,13,17-pentaenoic acid
DTXCID901333489