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15-Hydroxyicosatetraenoic acid

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Identification
Molecular formula
C20H32O3
CAS number
Select reference for specific isomer variant
IUPAC name
15-hydroxyicosa-5,8,11,13-tetraenoic acid
State
State

At room temperature, 15-Hydroxyicosatetraenoic acid is in a liquid state. It is generally synthesized or isolated in its pure form for research applications.

Melting point (Celsius)
-10.00
Melting point (Kelvin)
263.15
Boiling point (Celsius)
523.30
Boiling point (Kelvin)
796.45
General information
Molecular weight
320.47g/mol
Molar mass
320.4870g/mol
Density
0.9475g/cm3
Appearence

15-Hydroxyicosatetraenoic acid is typically a colorless to pale yellow liquid at room temperature. Its appearance is highly dependent on purity and storage conditions, as it can oxidize or decompose with exposure to air or high temperatures.

Comment on solubility

Solubility of 15-hydroxyicosa-5,8,11,13-tetraenoic acid (C20H32O3)

15-hydroxyicosa-5,8,11,13-tetraenoic acid, commonly referred to as a type of eicosanoid, exhibits interesting solubility characteristics that are noteworthy for both biological and chemical contexts.

Solubility in Different Solvents

This compound is expected to show variable solubility profiles in different solvent environments. Its solubility can be summarized as follows:

  • Water: Generally, fatty acids like 15-hydroxyicosa-5,8,11,13-tetraenoic acid have limited solubility in water due to their hydrophobic hydrocarbon chains.
  • Organic Solvents: It is more soluble in organic solvents such as ethanol and methanol, owing to the similar polar nature of these solvents compared to the acidic group in the molecule.
  • Oils and Lipids: Highly soluble in lipophilic environments such as oils, making it bioavailable in lipid-rich biological systems.

Factors Influencing Solubility

Several factors can influence the solubility of this compound:

  • Temperature: Increased temperature generally enhances solubility for most compounds, including fatty acids.
  • pH Levels: The ionization state of the carboxyl group can vary with pH, affecting solubility in aqueous environments.
  • Presence of Other Solutes: The presence of surfactants or other solubilizing agents can enhance solubility.

In summary, while 15-hydroxyicosa-5,8,11,13-tetraenoic acid may show low aqueous solubility, its affinity for organic solvents and lipids illustrates its relevance in biochemical pathways and interactions. Understanding these solubility characteristics is crucial for applications in pharmacology and biochemistry.

Interesting facts

Interesting Facts about 15-Hydroxyicosa-5,8,11,13-tetraenoic Acid

15-Hydroxyicosa-5,8,11,13-tetraenoic acid, commonly referred to as 15-HETE, is a fascinating compound that plays a significant role in various biological processes. Here are some intriguing aspects of this compound:

  • Role in Inflammation: 15-HETE is a key player in the inflammatory response. It is a product of arachidonic acid metabolism through lipoxygenase pathways, highlighting its importance in mediating inflammatory processes.
  • Cell Signaling: This compound functions as a signaling molecule, influencing cell proliferation and differentiation. It interacts with specific receptors, which can trigger a cascade of cellular responses.
  • Potential Therapeutic Applications: Research suggests that 15-HETE might be involved in various conditions, such as cardiovascular diseases and certain cancers. Understanding its mechanisms could lead to new therapeutic strategies.
  • Metabolism: The synthesis of 15-HETE occurs via enzymatic pathways involving lipoxygenases. This showcases the intricate biochemical network that regulates lipid metabolism in human physiology.

Moreover, some researchers refer to 15-HETE as a marker for certain physiological responses, underlining its potential in diagnostics and prognostics. With ongoing studies, there is promise that manipulation or monitoring of 15-HETE levels could yield significant advancements in medical research.

In summary, 15-hydroxyicosa-5,8,11,13-tetraenoic acid is not merely a compound of interest for its chemical structure; it embodies a bridge between chemistry and vital biological functions that could lead to breakthroughs in health and medicine.

Synonyms
15-hydroxyicosa-5,8,11,13-tetraenoic acid
(+/-)15-HETE
DTXSID20866448
73836-87-0
15(S)-HETE-d8
15(R)-HETE
HETE-15(S)
83603-31-0
DTXCID10814731
JDA80787
DB-052655