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Haloperidol

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Identification
Molecular formula
C21H23ClO2
CAS number
52-86-8
IUPAC name
15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one
State
State

At room temperature, haloperidol is typically in a solid form, specifically as a crystalline powder, and it is used in its solid state in pharmaceutical applications.

Melting point (Celsius)
148.50
Melting point (Kelvin)
421.65
Boiling point (Celsius)
524.20
Boiling point (Kelvin)
797.35
General information
Molecular weight
375.86g/mol
Molar mass
375.8640g/mol
Density
1.5260g/cm3
Appearence

Haloperidol is a white to faintly yellow crystalline powder. It is practically insoluble in water but is soluble in organic solvents.

The substance can appear as a tablet or as a liquid solution in its pharmaceutical preparations, but the pure compound itself maintains a solid crystalline form.

Comment on solubility

Solubility of 15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one

The solubility of the compound 15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one, with the chemical formula C21H23ClO2, exhibits some intriguing characteristics influenced by its complex structure.

When discussing the solubility of such compounds, it can be helpful to consider the following factors:

  • Polarity: The presence of hydroxyl groups (-OH) generally increases solubility in polar solvents like water, while chlorinated compounds often display greater solubility in nonpolar organic solvents.
  • Hydrophobic and Hydrophilic Interactions: This compound's molecular structure may lead to significant hydrophobic areas, which can influence its solubility profile. Hydrophobic compounds tend to be less soluble in water.
  • Molecular Size and Weight: The relatively large and complex structure of this compound suggests that it may have limited solubility in aqueous environments due to steric hindrance and intermolecular interactions.

In summary, while the compound may demonstrate some degree of solubility in organic solvents, its behavior in water is likely to be limited. As a general statement, "the structural intricacies and functional groups play a pivotal role in dictating the solubility behavior" of this unique compound.

Interesting facts

Exploring 15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one

This intriguing compound, a complex organic molecule, showcases the fascinating nature of chemical structures and their diverse functionalities. Here are some engaging facts about this compound:

  • Chemical Structure: The name suggests a pentacyclic framework, which is a hallmark of organic compounds exhibiting unique properties and applications. The multiple cyclic structures provide rigidity and stability.
  • Chlorine Presence: With the presence of a chlorine atom, this compound may exhibit interesting reactivity patterns, often enhancing biological activity or modifying the interaction with other substances.
  • Natural Products: Compounds like this are often derived from natural sources, hinting at potential applications in medicinal chemistry. They may be related to biologically active substances such as alkaloids or terpenoids.
  • Research Interest: Such structurally complex molecules are of great interest in the pharmaceutical field. They may serve as templates for drug development, with modifications leading to enhanced efficacy and reduced side effects.
  • Application Potential: The multiple functional groups, including hydroxyl and acetyl, suggest potential applications in fields ranging from agrochemicals to advanced materials.

As a scientific treasure, 15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one serves as a reminder of the intricate relationship between structure and function in chemistry. In the words of renowned chemist Linus Pauling, "The science of chemistry is essential to the understanding of biological processes." This compound encapsulates the beauty of chemistry and its implications for health and industry.

Synonyms
DTXSID20859698
1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1h)-one
DB-045447