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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
13-(hydroxymethyl)-10-isopropyl-9-methyl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraen-11-one
State
State

At room temperature, clozapine is a solid.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
748.80
Boiling point (Kelvin)
1 021.95
General information
Molecular weight
326.83g/mol
Molar mass
326.8310g/mol
Density
1.3160g/cm3
Appearence

Clozapine is typically found as a crystalline solid. It is often a pale yellow powder.

Comment on solubility

Solubility of 13-(hydroxymethyl)-10-isopropyl-9-methyl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraen-11-one

The solubility of the compound with the formula C18H19ClN4 is a complex characteristic that depends on several factors. This chemical, belonging to a class of triazatricyclo compounds, generally exhibits the following solubility properties:

  • Polar vs. Non-Polar Solvents: Compounds with significant functionalities and multiple nitrogen atoms, like this one, often exhibit better solubility in polar solvents such as water or alcohols compared to non-polar solvents.
  • Temperature Influence: The solubility of this compound may increase with temperature, a common phenomenon seen for many organic compounds.
  • pH Dependency: The solubility may also be affected by the pH of the solvent, particularly because of the presence of the nitrogen atoms that might interact with protons.
  • Hydrophobic Interactions: The isopropyl and methyl groups in its structure can induce hydrophobic interactions, which may limit the solubility in highly polar media but increase solubility in organic solvents.

As a take-home message, it is essential to explore the solubility of this compound within specific solvent systems to fully understand its behavior. Assessing solubility not only aids in the application of this compound in various fields but also gives valuable insights into its chemical nature.

Interesting facts

Interesting Facts about 13-(hydroxymethyl)-10-isopropyl-9-methyl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraen-11-one

This fascinating compound, recognized for its complex structure and diverse functional groups, holds immense potential in various fields of chemistry and pharmacology. Here are several notable insights about this intriguing molecule:

  • Complexity is Key: The presence of multiple heteroatoms, including nitrogen in the triazine moiety, contributes to the unique interactions this compound can exhibit with biological targets.
  • Versatile Chemistry: The hydroxymethyl and isopropyl groups enhance the molecule's ability to participate in various reactions, allowing it to serve as a versatile intermediate in synthetic organic chemistry.
  • Potential Applications: Compounds like this one, with their intricate frameworks, may have applications as pharmaceuticals, agrochemicals, or in materials science due to their structural properties and reactivity.
  • Structural Elucidation: The precise configuration of its three-dimensional structure can significantly impact its functionality; understanding this geometry plays a crucial role in designing analogs with improved activity.
  • Research Interest: The triazine-based structure is gaining attention in research for its potential antiviral and anticancer properties, indicating that this compound could be a candidate for further medicinal exploration.

In summary, the intricate design and versatile nature of 13-(hydroxymethyl)-10-isopropyl-9-methyl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraen-11-one highlight both the challenges and opportunities within the field of chemistry. As scientists continue to explore its characteristics and reactions, there is no telling what innovative applications may arise from this compound!

Synonyms
(-)-Indolactam V (low PS)
(+)-INDOLACTAM V
90365-56-3
BDBM86430
CAS_105000
NSC_105000
SMP2_000017
(10S,13S)-13-(hydroxymethyl)-9-methyl-10-propan-2-yl-3,9,12-triazatricyclo[6.6.1.0^{4,15]pentadeca-1,4(15),5,7-tetraen-11-one