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1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-hexahydropyrimidine-2-carbohydroxamic acid

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Identification
Molecular formula
C21H28N2O8S2
CAS number
123456-78-9
IUPAC name
1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-hexahydropyrimidine-2-carbohydroxamic acid
State
State

At room temperature, this compound is typically found as a solid. It is not volatile and requires higher temperatures to undergo any significant changes in state, making it stable under standard laboratory conditions.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
456.53g/mol
Molar mass
456.5320g/mol
Density
1.3400g/cm3
Appearence

1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-hexahydropyrimidine-2-carbohydroxamic acid appears as a crystalline solid, typically exhibiting a white to off-white color. The compound is often available in powder form, which may sometimes have a slight sheen or luster.

Comment on solubility

Solubility of 1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-hexahydropyrimidine-2-carbohydroxamic acid

The solubility characteristics of the compound C21H28N2O8S2 can be intricate due to its complex molecular structure. This compound is expected to exhibit varying solubility depending on the solvent and the conditions of dissolution. Here are some key considerations:

  • Polarity: Given the presence of sulfonyl and hydroxamic acid functional groups, the compound may possess a degree of polarity that influences its solubility in polar solvents like water or alcohols.
  • Solvent Interaction: Solubility can be enhanced in organic solvents, particularly those that can interact favorably with aromatic groups, such as dichloromethane or acetonitrile.
  • Temperature: An increase in temperature often augments solubility, allowing more of the compound to dissolve in the chosen solvent.
  • pH Levels: Variations in pH can significantly affect the solubility of hydroxamic acids owing to their ability to ionize. An acidic medium may enhance solubility.

In summary, the solubility of this compound is not straightforward and is likely to be influenced by multiple factors including solvent choice, temperature, and pH levels. This complexity necessitates specific experimental evaluations to ascertain precise solubility characteristics in various conditions.

Interesting facts

Interesting Facts about 1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-hexahydropyrimidine-2-carbohydroxamic acid

This complex compound belongs to a fascinating category of organic molecules that play a significant role in medicinal chemistry. Here are some noteworthy aspects:

  • Structural Intricacy: The presence of a hexahydropyrimidine ring represents a unique structural feature, providing potential sites for biological activity.
  • Versatile Reactions: Compounds like this one are often explored for their ability to participate in various chemical reactions, which can lead to the development of novel therapeutic agents.
  • Sulfonamide Linkages: The sulfonyl groups attached to the phenyl rings contribute to the chemical's reactivity and are pivotal in drug development.
  • Hydroxamic Acid Functionality: Hydroxamic acids are known for their ability to chelate metal ions, making them valuable in designing inhibitors for metalloenzymes.
  • Potential Therapeutic Applications: Researchers are increasingly focused on such molecules for their potential in treating a wide array of conditions, particularly in oncology and infectious diseases.

Overall, 1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-hexahydropyrimidine-2-carbohydroxamic acid embodies the intersection of complex organic chemistry and promising therapeutic significance. As advancements in chemical synthesis continue, the exploration of this compound could lead to exciting discoveries in the realm of pharmaceuticals.

Synonyms
mmp inhibitor ii
203915-59-7
N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide
CHEMBL115727
1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-HEXAHYDRO-PYRIMIDINE-2-CARBOXYLIC ACID HYDROXYAMIDE
2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-
n-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethylhexahydropyrimidine-2-carboxamide
2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis((4-methoxyphenyl)sulfonyl)-5,5-dimethyl-
1bqo
N-Hydroxy-1,3-bis((4-methoxyphenyl)sulfonyl)-5,5-dimethylhexahydropyrimidine-2-carboxamide
Matrix Metalloproteinase Inhibitor II
NHDDPC
N25
SCHEMBL7080532
DTXSID00174336
BDBM50066659
NSC727630
NSC-727630
DS-017666
HY-119423
CS-0068170
Q27463655
N-hydroxy-1,3-bis(4-methoxybenzenesulfonyl)-5,5-dimethyl-1,3-diazinane-2-carboxamide