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Benzoxazole

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Identification
Molecular formula
C7H5NO
CAS number
273-53-0
IUPAC name
1,3-benzoxazole
State
State

Benzoxazole is typically found as a solid at room temperature. It is slightly soluble in water but more soluble in organic solvents such as acetone and benzene.

Melting point (Celsius)
27.50
Melting point (Kelvin)
300.65
Boiling point (Celsius)
173.42
Boiling point (Kelvin)
446.57
General information
Molecular weight
119.13g/mol
Molar mass
119.1270g/mol
Density
1.1987g/cm3
Appearence

Benzoxazole is a colorless to pale yellow solid. It is often found in powder or crystalline form and has a distinct chemical odor.

Comment on solubility

Solubility of 1,3-benzoxazole

1,3-benzoxazole, with the chemical formula C7H5N1O, exhibits interesting solubility characteristics that are influenced by both its structural features and the surrounding environment. Here are some key points to consider:

  • Polarity: The presence of nitrogen and oxygen in the benzoxazole ring contributes to its overall polarity, which affects its solubility in different solvents.
  • Solvent Compatibility: 1,3-benzoxazole is typically soluble in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Ethanol
    • Acetone
  • Water Solubility: This compound has limited solubility in water, making it less favorable for aqueous applications. The **hydrophobic** characteristics of the benzene ring play a significant role in this behavior.
  • Temperature Dependency: As is common with many organic compounds, solubility may increase with temperature, allowing for more flexibility in various applications.

In summary, while 1,3-benzoxazole displays solubility in several organic solvents, its limited solubility in water suggests its considerations in chemical applications and interactions, highlighting the necessity of selecting appropriate solvents for effective solubilization.

Interesting facts

Interesting Facts about 1,3-Benzoxazole

1,3-Benzoxazole is a fascinating organic compound that belongs to the family of heterocyclic compounds. This compound has garnered attention for various reasons:

  • Structure and Stability: The unique structure of 1,3-benzoxazole includes a fused benzene ring and an oxazole ring. This configuration contributes to its stability and reactivity, making it a valuable building block in organic synthesis.
  • Fluorescent Properties: 1,3-Benzoxazole is recognized for its fluorescent properties, which are harnessed in various optical applications. Its ability to emit light under UV radiation makes it useful for labeling and detection in biochemical contexts.
  • Biological Activity: Research has indicated that 1,3-benzoxazole derivatives exhibit a wide range of biological activities. They are being explored for their potential as anti-inflammatory, antimicrobial, and anticancer agents. This has led to increased interest in their pharmacological applications.
  • A Versatile Intermediate: In synthetic organic chemistry, 1,3-benzoxazole serves as an important intermediate in the production of a variety of chemicals. It can be transformed into other functionalized compounds, thereby expanding its utility in chemical synthesis.
  • Applications in Material Science: The compound has found applications in material science, particularly in the development of certain dyes and polymers. Its fluorescent properties make it suitable for incorporation into smart materials.

In conclusion, 1,3-benzoxazole is more than just a compound; it embodies a spectrum of potential that spans across material science, biochemistry, and synthetic chemistry. As research continues to uncover its various applications, the significance of this compound is only expected to grow.

Synonyms
BENZOXAZOLE
273-53-0
1,3-Benzoxazole
1-Oxa-3-azaindene
1-Oxa-3-aza-1H-indene
BENZO[D]OXAZOLE
USAF EK-5017
Benzoxazoles
NSC 3982
EINECS 205-988-9
Benzooxazole
AI3-05743
J233Y1I55I
NSC-3982
MFCD00005765
DTXSID8059768
CHEBI:38814
UNII-J233Y1I55I
1Oxa3azaindene
NSC3982
1Oxa3aza1Hindene
Benzoxazole, 98%
1,3-Benzoxazole #
SCHEMBL7903
WLN: T56 BN DOJ
CHEMBL451894
DTXCID5037654
CHEBI:46700
AKOS000119993
CS-W004722
PS-3680
DB-029474
A3423
B0095
NS00028287
EN300-20396
H10149
A819031
Q761111
205-988-9