Skip to main content

12-HETE

ADVERTISEMENT
Identification
Molecular formula
C20H32O3
CAS number
74173-85-8
IUPAC name
12-hydroxyicosa-5,8,10,14-tetraenoic acid
State
State

At room temperature, 12-Hydroxyeicosatetraenoic acid is typically a liquid due to its unsaturated bonds which lower the melting point, preventing crystallization.

Melting point (Celsius)
-7.60
Melting point (Kelvin)
265.55
Boiling point (Celsius)
308.00
Boiling point (Kelvin)
581.15
General information
Molecular weight
320.49g/mol
Molar mass
320.4940g/mol
Density
1.0050g/cm3
Appearence

12-Hydroxyeicosatetraenoic acid (12-HETE) appears as a colorless to pale yellow liquid, characteristic of many unsaturated fatty acids. It is often found as a free acid or in an esterified form with a slightly oily consistency.

Comment on solubility

Solubility of 12-hydroxyicosa-5,8,10,14-tetraenoic acid (C20H32O3)

12-hydroxyicosa-5,8,10,14-tetraenoic acid, often referred to for its chemical structure, demonstrates a specific solubility characteristic based on its molecular composition. This compound contains both hydrophobic and hydrophilic functional groups, which significantly influences its solubility profile.

Key Points about Solubility:

  • Solvent Compatibility: It is likely to dissolve well in organic solvents due to its long hydrophobic carbon chain.
  • Water Solubility: Its solubility in water is expected to be limited. The presence of hydroxyl groups can enhance interactions with water molecules, but the large hydrophobic portion dominates.
  • Temperature Dependence: Generally, solubility in organic solvents may increase with temperature, allowing for better dissolution of the compound.
  • pH Influence: The ionization behavior of the hydroxyl group can also alter solubility in different pH environments.

In summary, while 12-hydroxyicosa-5,8,10,14-tetraenoic acid exhibits limited water solubility, it is expected to be more soluble in various organic solvents, reflecting a typical behavior of long-chain fatty acids and their derivatives.

Interesting facts

Interesting Facts about 12-Hydroxyicosa-5,8,10,14-tetraenoic Acid

12-Hydroxyicosa-5,8,10,14-tetraenoic acid, often abbreviated as 12-HETE, is a fascinating compound with several significant biological roles. It is one of the products of the metabolism of arachidonic acid, a key fatty acid found in cell membranes. This compound stands out for its involvement in several physiological processes:

  • Inflammation: 12-HETE plays a key role in the inflammatory response, influencing various cellular activities and immune responses.
  • Cell migration: It has been shown to promote the migration of certain types of cells, particularly in wound healing and tissue regeneration.
  • Neuroprotection: Research suggests that 12-HETE may contribute to neuroprotective mechanisms, showing promise in neurodegenerative disease studies.

Additionally, this compound is formed enzymatically by the action of lipoxygenase on arachidonic acid, and its synthesis is tightly regulated within the body. Such regulation highlights its importance in maintaining homeostasis and suggests a complex interplay with other signaling molecules.

Biological Significance

In studying 12-HETE, scientists have noted its multifaceted role in health and disease. It is implicated in:

  • Cancer biology: Some studies indicate that 12-HETE may be involved in tumor progression and metastasis.
  • Cardiovascular health: By modulating platelet aggregation, it could influence thrombus formation, which is critical in heart disease.

With its diverse effects and pathways, 12-hydroxyicosa-5,8,10,14-tetraenoic acid serves as a prime example of how a single biochemical compound can exert profound effects on human physiology. Ongoing research continues to explore its potential therapeutic applications and how it can be harnessed to benefit human health. As such, 12-HETE stands not only as a subject of fascination within biochemistry but also as a beacon of hope for future medical advancements.

Synonyms
12-hydroxyicosa-5,8,10,14-tetraenoic acid
12-Hete
DTXSID30869349
71030-37-0
DTXCID10817343
ZNHVWPKMFKADKW-UHFFFAOYSA-N
HDA33746
WCA03037
PD093583
DB-056600
DB-226145
NS00127274
12-hydroxyeicosa-5,8,10,14-tetraenoic acid
12-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid, 100ug/ml in ethanol