Skip to main content

Benzoxazole methanesulfonamide

ADVERTISEMENT
Identification
Molecular formula
C8H8N2O3S
CAS number
303764-55-6
IUPAC name
1,2-benzoxazol-3-ylmethanesulfonamide
State
State

In its standard state, benzoxazole methanesulfonamide is a solid. It remains stable under normal temperature and pressure conditions.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
346.00
Boiling point (Kelvin)
619.15
General information
Molecular weight
214.24g/mol
Molar mass
214.2420g/mol
Density
1.4510g/cm3
Appearence

Benzoxazole methanesulfonamide typically appears as a crystalline solid. It is often white to off-white in color. The crystals are fine and show a uniform appearance.

Comment on solubility

Solubility of 1,2-benzoxazol-3-ylmethanesulfonamide

The solubility of 1,2-benzoxazol-3-ylmethanesulfonamide (C8H8N2O3S) can be quite interesting due to its unique chemical structure. Here are some factors that influence its solubility:

  • Polarity: The presence of both sulfonamide and benzoxazole groups leads to a balance of polar and nonpolar characteristics, which can affect its solubility in different solvents.
  • Solvent Compatibility: It is generally more soluble in polar solvents such as water and dimethyl sulfoxide (DMSO). This can be attributed to the hydrogen bonding capability of the sulfonamide moiety.
  • pH Influence: The solubility might increase in acidic or basic conditions due to protonation or deprotonation of the functional groups.
  • Temperature: Like many compounds, its solubility can increase with temperature, allowing for a more optimal dissolution when heated.

Studies suggest that solubility can vary widely depending on the conditions, and while it may be sparingly soluble in organic solvents, its ability to interact with water molecules through hydrogen bonds enhances its aqueous solubility, marking it as a compound of significant interest in various chemical applications.

Interesting facts

Interesting Facts about 1,2-benzoxazol-3-ylmethanesulfonamide

The compound 1,2-benzoxazol-3-ylmethanesulfonamide is an intriguing member of the benzoxazole family, which is derived from the combination of a benzene ring and an oxazole ring. It's widely noted for its various applications in the field of medicinal chemistry.

Key Highlights:

  • Mechanism of Action: This compound acts as an inhibitor in various biochemical pathways, showing promising activity against specific enzymes which may play a role in disease progression.
  • Biological Activity: Numerous studies have suggested that derivatives of benzoxazole, including this compound, exhibit noteworthy antimicrobial and anticancer properties.
  • Versatile Applications: From serving as a scaffold for drug design to being an important research tool in biochemistry, its adaptability makes it a compound of interest in pharmaceutical development.
  • Research Potential: The structural attributes of 1,2-benzoxazol-3-ylmethanesulfonamide allow chemists to modify and optimize its properties, thus paving the way for advanced therapeutic agents.

In the realm of medicinal chemistry, the importance of such compounds cannot be overstated. As researchers say, "Innovation lies in the unexpected connections." In this respect, the unique structure of benzoxazole derivatives like this one may lead to breakthroughs in drug discovery and the treatment of various diseases.

Continuing to explore the chemistry and potential benefits of 1,2-benzoxazol-3-ylmethanesulfonamide may reveal even more captivating uses in the future, solidifying its status as a valuable asset within the chemical sciences.

Synonyms
zonisamide
68291-97-4
Zonegran
1,2-Benzisoxazole-3-methanesulfonamide
Exceglan
Excegram
1,2-benzoxazol-3-ylmethanesulfonamide
Excegran
Zonisamida
AD-810
Zonisamidum
Zonisamidum [Latin]
Zonisamida [Spanish]
CI-912
3-(Sulfamoylmethyl)-1,2-benzisoxazole
PD-110843
benzo[d]isoxazol-3-ylmethanesulfonamide
ZONISADE
PD 110843
HSDB 7293
C8H8N2O3S
BRN 1077076
DTXSID9046023
CHEBI:10127
N03AX15
1-(1,2-Benzoxazol-3-Yl)methanesulfonamide
UNII-459384H98V
1-(1,2-benzisoxazol-3-yl)methanesulfonamide
CHEMBL750
SPR_2
Benzo[d]isoxazol-3-yl-methanesulfonamide
459384H98V
DTXCID7026023
Zonisamidum (Latin)
Zonisamide [USAN:USP:INN:BAN:JAN]
1,2-Benzisoxazol-3-ylmethanesulfonamide
NCGC00159319-02
NCGC00159319-04
ZONISAMIDE (MART.)
ZONISAMIDE [MART.]
ZONISAMIDE (USP-RS)
ZONISAMIDE [USP-RS]
Tremode
Trerief
ZONISAMIDE (USP MONOGRAPH)
ZONISAMIDE [USP MONOGRAPH]
Zonisamide (USAN:USP:INN:BAN:JAN)
Benzo(d)isoxazol-3-yl-methanesulfonamide
Excegran (TN)
SMR000596519
Zonisamide (ZNS)
CAS-68291-97-4
SR-01000837537
MFCD00865316
Zonisamide, ZNS
1,2-Benzisoxazole-3-methanesulfonamide;3-(Sulfamoylmethyl)-1,2-benzisoxazole;AD 810
AD-810N
Zonisamide, 1
Zonisamide (Standard)
ZONISAMIDE [MI]
ZONISAMIDE [INN]
ZONISAMIDE [JAN]
ZONISAMIDE [HSDB]
ZONISAMIDE [USAN]
ZONISAMIDE [VANDF]
E-2090
ZONISAMIDE [WHO-DD]
BIDD:PXR0183
SCHEMBL35458
MLS001195632
MLS001306491
BIDD:GT0708
ZONISAMIDE [EMA EPAR]
GTPL7047
Zonisamide (JP18/USP/INN)
ZONISAMIDE [ORANGE BOOK]
BDBM10888
HY-B0124R
Zonisamide - Bio-X trade mark
HMS2089O07
HMS2235L13
HMS3259N09
HMS3269F21
HMS3413L09
HMS3657E03
HMS3677L09
HMS3714E19
HMS3742M15
HMS3884I17
Zonisamide 1.0 mg/ml in Methanol
BCP28480
HY-B0124
Tox21_111569
BBL010040
HB0675
s1445
STK711131
AKOS001312269
Tox21_111569_1
AC-1413
CCG-220669
CS-1888
DB00909
FB28784
KS-1142
NC00637
(1,2-benzoxazol-3-yl)methanesulfonamide
NCGC00159319-03
BZ164593
NS00000539
SW199135-2
Z0026
EN300-50288
C07504
C76163
D00538
AB00876297-09
AB00876297-10
AB00876297_11
Zonisamide pound>>CI-912 pound>>PD 110843
A836085
Q219957
SR-01000837537-2
SR-01000837537-3
SR-01000837537-8
BRD-K48300629-001-03-8
BRD-K48300629-001-13-7
BRD-K48300629-001-14-5
Z223042524