Topiramate | Solubility of Things

Identification

Molecular formula

C₁₂H₂₁NO₈S

CAS number

97240-79-4

IUPAC name

(11,11-dimethyl-4,4-dioxo-3,5,8,10,12-pentaoxa-4lambda6-thiatricyclo[7.3.0.02,6]dodecan-9-yl)methyl sulfamate

State

Topiramate is typically found as a solid at room temperature.

Melting point (Celsius)

125.00

Melting point (Kelvin)

398.15

Boiling point (Celsius)

382.30

Boiling point (Kelvin)

655.45

General information

Molecular weight

339.36g/mol

Molar mass

339.3630g/mol

Density

1.3577g/cm³

Appearence

Topiramate appears as a white crystalline powder. It is odorless and slightly soluble in water and acidic solutions but more soluble in alkaline solutions.

Comment on solubility

Solubility of (11,11-dimethyl-4,4-dioxo-3,5,8,10,12-pentaoxa-4lambda6-thiatricyclo[7.3.0.02,6]dodecan-9-yl)methyl sulfamate

The solubility of the compound with the formula C₁₂H₂₁NO₈S can be influenced by several factors, given its complex structure. Here are some key points regarding its solubility:

Polarity: The presence of oxygen and sulfur atoms in the molecule suggests a degree of polarity that could contribute to solubility in polar solvents, such as water.
Hydrophilicity: The multiple oxygens in the structure may enhance interactions with water, leading to increased solubility. However, steric hindrance due to the bulky groups may inhibit complete dissolution.
Solvent Influence: The solubility might vary significantly depending on the solvent used. For example, organic solvents might solubilize the compound differently than aqueous solutions.
Temperature Effects: As with many compounds, increasing the temperature may improve solubility by providing more energy for interactions between the solute and solvent molecules.
Concentration Factors: At high concentrations, solubility phenomena, such as supersaturation, might occur, impacting the effective solubility of the compound.

In summary, while the solubility is primarily dictated by structural features and the interactions with various solvents, the specific behavior in solution may require experimental validation for precise recommendations. As always, the solubility can be context-dependent, emphasizing the need for careful consideration in practical applications.

Interesting facts

Interesting Facts about (11,11-dimethyl-4,4-dioxo-3,5,8,10,12-pentaoxa-4lambda6-thiatricyclo[7.3.0.02,6]dodecan-9-yl)methyl sulfamate

This compound is a fascinating example of complexity in organic chemistry, featuring a unique structure and diverse functionalities. Here are some intriguing aspects to consider:

Cyclic Structure: The presence of a thiatricyclo ring system introduces unique steric and electronic properties, allowing for various interactions that can alter reactivity.
Functional Groups: The compound houses an impressive array of functional groups, including sulfamate and multiple carbonyl groups, contributing to its potential applications and reactivity.
Potential Applications: Due to its structural intricacies, it may serve as a valuable precursor or intermediate in the synthesis of more complex molecules, possibly in pharmaceuticals or agricultural chemicals.
Biological Studies: Compounds with such functional diversity have been of interest in biochemical studies, particularly in exploring their potential roles in biological systems.
Challenging Synthesis: The synthesis of this compound is likely to be quite challenging, requiring advanced techniques and methodologies to achieve the specific stereochemistry and functionality in a controlled manner.

In summary, the structural complexity and functional versatility of (11,11-dimethyl-4,4-dioxo-3,5,8,10,12-pentaoxa-4lambda6-thiatricyclo[7.3.0.02,6]dodecan-9-yl)methyl sulfamate make it a compelling subject for further research and exploration within the field of chemistry.