Brinzolamide | Solubility of Things

Identification

Molecular formula

C₁₂H₂₁BrClN₇O₂S₃

CAS number

138890-62-7

IUPAC name

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

State

At room temperature, Brinzolamide is commonly in a solid state. It is processed into pharmaceutical forms such as ophthalmic suspension for medical applications.

Melting point (Celsius)

131.50

Melting point (Kelvin)

404.65

Boiling point (Celsius)

220.00

Boiling point (Kelvin)

493.15

General information

Molecular weight

383.43g/mol

Molar mass

383.4290g/mol

Density

1.7383g/cm³

Appearence

Brinzolamide is typically found as a white to off-white crystalline powder. It may also be seen as a solid that is odorless.

Comment on solubility

Solubility of 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

The solubility of the compound 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide (C₁₂H₂₁BrClN₇O₂S₃) can be influenced by several factors:

Polarity: The presence of functional groups, such as sulfonamide and trifluoromethyl groups, contributes to both polar and non-polar characteristics, thus affecting solubility in various solvents.
Solvent Compatibility: Generally, this compound is more soluble in polar solvents such as water and methanol, while exhibiting lower solubility in non-polar solvents like hexane.
Temperature Effects: As with many chemical compounds, increasing the temperature typically enhances solubility; thus, this compound can dissolve better at elevated temperatures.

Since solubility plays a crucial role in both biological activity and industrial applications, understanding its solubility profile helps in predicting the behavior of this compound in various environments. Notably, researchers often highlight the importance of solubility in drug development, stating that “the efficacy of a compound is often limited by its solubility.” Therefore, assessing the solubility of C₁₂H₂₁BrClN₇O₂S₃ is vital for its practical applications.

Interesting facts

Interesting Facts about 1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

This compound is a fascinating member of the benzothiadiazine family, a group known for its unique structures and diverse applications in medicinal chemistry. Here are some noteworthy aspects of this compound:

Pharmaceutical Relevance: Benzothiadiazines are often evaluated for their potential as pharmacological agents, notably as diuretics and antihypertensives.
Interesting Substituents: The presence of a trifluoromethyl group can significantly influence the biological properties of compounds, enhancing their lipophilicity and metabolic stability.
Multifunctionality: This compound's sulfonamide group may contribute to its effectiveness in medical applications, as sulfonamides are often used as antibiotics and antiviral agents.
Structure-Activity Relationship (SAR): Understanding the structure of this compound allows researchers to predict its biological activity and develop derivatives that may be more effective in targeting specific biological pathways.
Synthetic Pathways: The synthesis of such complex compounds showcases the ingenuity of modern organic chemistry and the development of innovative strategies to create highly specific molecular structures.

Combining these features, 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide represents a compelling area of study for chemists interested in drug design and development. As Albert Einstein famously said, "Pure mathematics is, in its way, the poetry of logical ideas." In a similar vein, the synthesis and study of complex chemical compounds can be seen as a form of artistic expression within the realm of scientific inquiry.

Synonyms

hydroflumethiazide

135-09-1

Diuredemina

Glomerulin

Robezon

Saluron

Hidroflumetiazid

Hydroflumethizide

Diucardin

Diurometon

Flutizide

Hidroalogen

Spandiuril

Bristab

Enjit

Bristurin

Elodrine

Finuret

Hydrenox

Leodrine

Olmagran

Rodiuran

Sisuril

Vergonil

Hydol

Rontyl

Trifluoromethylhydrothiazide

NaClex

Di-ademil

Dihydroflumethazide

Dihydroflumethiazide

Trifluoromethylhydrazide

Elodrin

Hidroflumetiazida

Hydroflumethazide

Metforylthiadiazin

Metflorylthiazidine

Rivosil

Idroflumetiazide

Metforylthiazidin

Di-adenil

Hydroflumethiazidum

Methforylthiazidine

Naciex (glaxo)

6-(Trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

NSC 44627

component of Salutensin

Hidroflumetiazida [INN-Spanish]

Hydroflumethiazidum [INN-Latin]

HSDB 3340

3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

EINECS 205-173-8

NSC-44627

UNII-501CFL162R

6-(Trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

6-Trifluoromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

BRN 0342692

CHEBI:5784

DTXSID3023132

501CFL162R

6-Trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide

7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

3,4-Dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine 1,1-dioxide

3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

NSC44627

7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1, 1-dioxide

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

MLS000028516

DTXCID203132

4-27-00-08035 (Beilstein Handbook Reference)

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

6-(Trifluoromethyl)-3,4-dihydro-2H-benzo-[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Hydroflumethiazide [USP:INN:BAN:JAN]

NCGC00016401-01

CAS-135-09-1

SMR000058284

SALUTENSIN COMPONENT HYDROFLUMETHIAZIDE

Idroflumetiazide [DCIT]

Hidroflumetiazida (INN-Spanish)

Hydroflumethiazidum (INN-Latin)

HYDROFLUMETHIAZIDE (MART.)

HYDROFLUMETHIAZIDE [MART.]

HYDROFLUMETHIAZIDE (USP-RS)

HYDROFLUMETHIAZIDE [USP-RS]

3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide

Hydroflumethiazide (USP:INN:BAN:JAN)

HYDROFLUMETHIAZIDE (USP MONOGRAPH)

HYDROFLUMETHIAZIDE [USP MONOGRAPH]

Saluron (TN)

SR-01000003094

Hydroflumethiazide (JAN/USP/INN)

Prestwick_268

MFCD00057316

Spectrum_000905

Opera_ID_326

Prestwick0_000013

Prestwick1_000013

Prestwick2_000013

Prestwick3_000013

Spectrum2_001010

Spectrum3_000460

Spectrum4_000010

Spectrum5_000832

cid_3647

3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide

CHEMBL1763

SCHEMBL27028

BSPBio_000045

BSPBio_002140

Hydroflumethiazide (Standard)

KBioGR_000359

KBioSS_001385

MLS001148090

DivK1c_000512

SPECTRUM1500341

BMCL182567 Compound 6b

SPBio_001139

SPBio_001966

HYDROFLUMETHIAZIDE [MI]

BPBio1_000051

GTPL7197

HYDROFLUMETHIAZIDE [INN]

HYDROFLUMETHIAZIDE [JAN]

BDBM25897

HMS501J14

HYDROFLUMETHIAZIDE [HSDB]

KBio1_000512

KBio2_001385

KBio2_003953

KBio2_006521

KBio3_001360

C03AA02

HYDROFLUMETHIAZIDE [VANDF]

NINDS_000512

3,2,4-thiadiazine 1,1-dioxide

HMS1568C07

HMS1920F05

HMS2091L13

HMS2095C07

HMS2235E09

HMS3259C15

HMS3371H03

HMS3712C07

Pharmakon1600-01500341

HYDROFLUMETHIAZIDE [WHO-DD]

AAA13509

HY-W011240R

Tox21_110422

CCG-40228

NSC757071

s9504

3,2,4-benzothiadiazine 1,1-dioxide

6-Trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide

7-Sulfamoyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

AKOS015913797

Tox21_110422_1

CS-W011956

DB00774

HY-W011240

NC00496

NSC-757071

2H-1,2, 4-Benzothiadiazine-7-sulfonamide, 3, 4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

3, 4-Dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine 1, 1-dioxide

3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

3,4-Dihydro-7-sulfamoyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

6-Trifluoromethyl-3, 4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

6-Trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2, 4-benzothiadiazine-1,1-dioxide

HYDROFLUMETHIAZIDE [ORANGE BOOK]

IDI1_000512

NCGC00016401-02

NCGC00016401-03

NCGC00016401-04

NCGC00016401-05

NCGC00016401-06

NCGC00016401-09

NCGC00023353-03

NCGC00023353-04

WLN: T66 BSWM EM DHJ HXFFF ISZW

SBI-0051411.P003

DB-042267

AB00052016

NS00004317

Hydroflumethiazide, analytical standard, ~97%

C07763

D00654

EN300-125439

G76938

AB00052016_15

HYDROFLUMETHIAZIDE COMPONENT OF SALUTENSIN

3,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Q3791957

SR-01000003094-2

SR-01000003094-3

SR-01000003094-5

6-Trifluoromethyl-3,2,4-benzothiadiazine 1,1-dioxide

BRD-K36862742-001-05-8

BRD-K36862742-001-15-7

BRD-K36862742-001-24-9

BRD-K36862742-001-25-6

Z1575271347

6-Trifluoromethyl-7-sulfamoyl-3,2,4-benzothiadiazine-1,1-dioxide

7-Sulfamoyl-6-trifluoromethyl-3,2,4-benzothiadiazine 1,1-dioxide

Hydroflumethiazide, United States Pharmacopeia (USP) Reference Standard

1,1-Dioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydro-2,4-benzothiadiazine-7-sulfonamide

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6,2,4-benzothiadiazine-7-sulfonamide

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1|E6,2,4-benzothiadiazine-7-sulfonamide

1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

2H-1,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

3, 4-Dihydro-6-trifluoromethyl-2H-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide

3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide

3,4-Dihydro-7-sulfamoyl-6-trifluoromethyl-2H-1,2, 4-benzothiadiazine 1,1-dioxide

6-(Trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide #

6-(Trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide1,1-dioxide

7-Sulfamoyl-6-trifluoromethyl-3, 4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

205-173-8