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Mifepristone

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Identification
Molecular formula
C29H35NO2
CAS number
84371-65-3
IUPAC name
11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
State
State

Mifepristone is a solid at room temperature, typically encountered as a powder due to its crystalline structure. This solid form contributes to its stability and ease of handling in various pharmaceutical applications.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.20
Boiling point (Celsius)
668.70
Boiling point (Kelvin)
941.90
General information
Molecular weight
429.58g/mol
Molar mass
429.5790g/mol
Density
1.1660g/cm3
Appearence
Mifepristone is a pale yellow, crystalline powder. It may vary slightly in hue, but generally maintains a consistent coloration and texture. The substance is known for its crystalline nature, contributing to its solid, stable form at room temperature.
Comment on solubility

Solubility of 11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

The solubility of the compound with the formula C29H35NO2 is an essential characteristic to consider in various applications, particularly in pharmacology and material science. Understanding its solubility can help predict its behavior in different environments. Here are some notable points:

  • Polarity Matters: The presence of a dimethylamino group may enhance aqueous solubility due to its polar nature, while the hydrocarbon framework could contribute to hydrophobic interactions.
  • Solvent Influence: Solubility is significantly affected by the choice of solvent. For instance, organic solvents like ethanol or methanol may dissolve this compound better than water.
  • Temperature Dependency: Typically, an increase in temperature can enhance solubility. This is crucial when considering temperature-controlled processes.
  • Effect of pH: The ionization of the dimethylamino group can vary with pH, potentially leading to different solubility profiles in more acidic or basic environments.

In summary, the solubility of this compound is likely to be influenced by its structural components, solvent system, and environmental conditions. As underscored by the phrase: "The right solvent can make all the difference." Being informed about these factors ensures better handling and utilization of this chemical in various applications.

Interesting facts

Interesting Facts about 11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

This compound presents an intriguing blend of structural complexity and potential applications in the field of medicinal chemistry. Here are some fascinating aspects to consider:

  • Structural Diversity: The compound is characterized by a unique polycyclic framework, which includes decahydrocyclopenta[a]phenanthrene. This complex structure contributes to its biological activity and interaction with various biomolecules.
  • Biological Relevance: Compounds like this one often serve as integral parts of pharmaceutical research. The presence of the dimethylamino group can enhance its lipophilicity, allowing for better membrane permeability and enhanced pharmacokinetic properties.
  • Potential Therapeutic Uses: Derivatives of this compound may exhibit promising activity in treating conditions such as cancer or neurodegenerative diseases due to their ability to interact with specific proteins and enzymes in the body.
  • Research Significance: Studies involving similar compounds provide substantial insights into structure-activity relationships (SAR), helping researchers design even more effective therapeutic agents.
  • Synthetic Challenges: The synthesis of such highly substituted polycyclic systems can be quite challenging, often requiring advanced methodologies in organic synthesis, making this compound a fascinating subject of study for chemists.

As a student or scientist, it's important to appreciate not only the chemical properties but also the broader implications of such compounds in drug discovery and development. The intricate relationship between chemical structure and biological function continues to be a vital area of exploration in chemistry.

Synonyms
11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(prop-1-yn-1-yl)estra-4,9-dien-3-one
SCHEMBL4457529
CHEMBL3188048
BDBM86689
CHEBI:91715
DTXSID70861069
VKHAHZOOUSRJNA-UHFFFAOYSA-N
HMS3267N14
QAB73679
BBL030162
NSC_55245
STL257061
AKOS022102233
NCGC00015700-02
VS-09648
CAS_84371-65-3
NS00014348
BRD-A44780397-001-01-1
Q27163530
11.beta.-[p-(Dimethylamino)phenyl]-17.beta.-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
(8S,11R,13R,14S,17S)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
10-[4-(dimethylamino)phenyl]-1-hydroxy-11a-methyl-1-(prop-1-yn-1-yl)-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
11-[4-(Dimethylamino)phenyl]-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one