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Clonazolam

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Identification
Molecular formula
C17H12Cl2N4O2
CAS number
33887-02-4
IUPAC name
10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6-one
State
State

State at Room Temperature: Clonazolam is typically a solid at room temperature.

Melting point (Celsius)
170.30
Melting point (Kelvin)
443.45
Boiling point (Celsius)
440.90
Boiling point (Kelvin)
714.05
General information
Molecular weight
353.22g/mol
Molar mass
353.2170g/mol
Density
1.3000g/cm3
Appearence

Clonazolam typically appears as a white powder or crystalline solid. It is often pressed into tablet form or dissolved in solution for research and experimental purposes.

Comment on solubility

Solubility of 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6-one

The solubility of the compound C17H12Cl2N4O2, commonly referenced as 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6-one, can be assessed through various factors:

  • Polarity: The presence of chlorine and nitrogen atoms suggests that the compound could exhibit polar characteristics, which typically influences solubility in polar solvents.
  • Hydrogen Bonding: The functional groups present may allow for hydrogen bonding, potentially enhancing solubility in water but complicating solubility in non-polar solvents.
  • Solvent Compatibility: Similar to many organic compounds, it is likely to show better solubility in organic solvents such as dichloromethane, ethanol, or acetone.
  • Temperature Effects: As is common with many chemical compounds, solubility may increase with temperature, so varying the thermal conditions may yield differing solubility profiles.

In summary, while the exact solubility data for this specific compound may not be readily available, examining its structural features provides valuable insights into its expected behavior in various solvents. It is advisable to perform empirical studies to ascertain its precise solubility characteristics under specific conditions.

Interesting facts

Interesting Facts about 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6-one

This compound, complex in its structure, represents a fascinating intersection of medicinal chemistry and organic synthesis. It belongs to the class of benzodiazepines, which are known for their psychoactive properties.

Key Highlights:

  • Diverse Applications: Benzodiazepines, including this compound, are widely used in pharmaceuticals as anxiolytics, sedatives, hypnotics, and anticonvulsants.
  • Mechanism of Action: These compounds typically work by enhancing the effect of the neurotransmitter GABA (gamma-aminobutyric acid) at the GABAA receptor. This results in a calming effect on the central nervous system.
  • Synthetic Routes: The synthesis of this particular compound involves intricate methods that showcase the beauty and complexity of organic chemistry. Multi-step synthesis often requires advanced techniques in purification and characterization.
  • Potential Research Opportunities: The unique structure of this compound could present exciting avenues for research into new medications with improved efficacy and reduced side effects compared to existing therapies.

One of the intriguing aspects of compounds like this is their structural diversity. The presence of halogen atoms, such as chlorine, can significantly impact the compound's biological activity and properties. As the field of medicinal chemistry continues to evolve, discovering and studying such complex compounds remains essential for the development of innovative therapeutic agents.

Furthermore, this compound exemplifies a blend of chemistry and pharmacology, making it a valuable subject for students and researchers alike. The ability to understand and manipulate such structures not only enhances our knowledge of chemical reactivity but also serves to bridge the gap between lab research and real-world applications in healthcare.

Synonyms
mexazolam
Melex
31868-18-5
CS-386
Mexazolamum
Mexazolam [INN:JAN]
Mexazolamum [INN-Latin]
CS 386
BRN 1091849
Melex (TN)
DTXSID9057715
CHEBI:31842
MEXAZOLAM [INN]
MEXAZOLAM [JAN]
MEXAZOLAM [MI]
MEXAZOLAM [MART.]
MEXAZOLAM [WHO-DD]
10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
DTXCID0031504
S5969B6237
10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
10-Chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
Mexazolamum (INN-Latin)
MEXAZOLAM (MART.)
Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyl-
Mexazolam (1.0mg/ml in Acetonitrile)
10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d][1,4]diazepin-6(5H)-one
10-chloro-2,3,7,11b-tetrahydro-3-methyl-11b-(2-chlorophenyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
Sedoxil
UNII-S5969B6237
10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one; CS 386; Melex
13-chloro-2-(2-chlorophenyl)-5-methyl-3-oxa-6,9-diazatricyclo(8.4.0.0^(2,6))tetradeca-1(10),8,11,13-tetraen-8-ol
13-chloro-2-(2-chlorophenyl)-5-methyl-3-oxa-6,9-diazatricyclo(8.4.0.02,6)tetradeca-1(10),8,11,13-tetraen-8-ol
13-chloro-2-(2-chlorophenyl)-5-methyl-3-oxa-6,9-diazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),8,11,13-tetraen-8-ol
13-chloro-2-(2-chlorophenyl)-5-methyl-3-oxa-6,9-diazatricyclo[8.4.0.02,6]tetradeca-1(10),8,11,13-tetraen-8-ol
Mexazolam (JAN/INN)
SCHEMBL218453
CHEMBL1743261
ANUCDXCTICZJRH-UHFFFAOYSA-N
GBA86818
Tox21_113740
AKOS040753046
DB15489
NCGC00253606-01
CAS-31868-18-5
NS00120155
D01316
Q6148446