Skip to main content

Clomipramine

ADVERTISEMENT
Identification
Molecular formula
C19H23ClN2O
CAS number
303-49-1
IUPAC name
10-amino-9-chloro-2-methyl-2,7-diazatricyclo[6.3.1.04,12]dodeca-1(12),3,7,9-tetraen-11-one
State
State
Clomipramine is typically found in a solid state at room temperature. It is used in the form of hydrochloride salt in pharmaceutical products for increased stability and solubility.
Melting point (Celsius)
191.00
Melting point (Kelvin)
464.15
Boiling point (Celsius)
282.00
Boiling point (Kelvin)
555.15
General information
Molecular weight
314.86g/mol
Molar mass
314.2560g/mol
Density
1.3456g/cm3
Appearence

Clomipramine hydrochloride is a white or slightly beige powder that is odorless or almost odorless. It is highly soluble in water and methanol, and slightly soluble in acetone and alcohol. It often takes the form of crystalline powder when isolated.

Comment on solubility

Solubility of 10-amino-9-chloro-2-methyl-2,7-diazatricyclo[6.3.1.04,12]dodeca-1(12),3,7,9-tetraen-11-one

The solubility of the compound C19H23ClN2O, commonly referred to by its systematic name, can be quite intriguing. Such a complex structure often influences its solubility in various solvents. Key factors to consider include:

  • Polarity: The presence of functional groups, such as the amino group and chlorine atom, can significantly affect the compound's polarity, impacting its ability to dissolve.
  • Solvent Type: Typically, organic compounds similar to this one tend to have increased solubility in non-polar solvents. However, some polar solvents might facilitate solubility due to hydrogen bonding interactions.
  • Temperature: Increased temperatures generally enhance solubility, allowing for greater molecular motion and interaction with the solvent.

In general, it's anticipated that this compound may exhibit limited solubility in water due to its large, complex structure. Conversely, it might dissolve better in organic solvents, such as ethanol or DMSO, where the molecular interactions can be more favorable. As a guiding principle, one can state that “like dissolves like”, emphasizing the importance of matching the solvent's polarity to the compound's characteristics.

Overall, understanding the solubility behavior of such compounds is crucial for various applications in chemical synthesis and pharmaceuticals.

Interesting facts

Interesting Facts about 10-amino-9-chloro-2-methyl-2,7-diazatricyclo[6.3.1.04,12]dodeca-1(12),3,7,9-tetraen-11-one

This compound, known for its unique structural features, belongs to a class of chemical compounds that exhibit a significant degree of complexity in their molecular architecture. Here are some engaging aspects to consider:

  • Diverse Applications: Compounds like this one play crucial roles in medicinal chemistry. They are often explored for their potential in drug design due to their intricate structures that can interact in diverse biological systems.
  • Structural Intricacies: The molecular structure incorporates various functional groups that can lend themselves to interesting reactivity patterns. The presence of Amino and Chloro substituents suggests potential sites for further chemical modifications, enhancing the compound’s versatility.
  • Historical Significance: The study of such diazatricyclic compounds has paved the way for advancements in organic synthesis and has contributed to our understanding of complex nitrogenous compounds in nature.
  • Potential Biological Activity: Many compounds with similar structures exhibit notable biological activities, including antimicrobial and anticancer properties, making them interesting candidates for pharmacological research.
  • Research Opportunities: With ongoing research in the field of materials science and nanotechnology, compounds like this may have potential applications in the development of new materials with tailored properties.

As we delve deeper into the study of this fascinating compound, we are reminded of the endless possibilities within the world of chemistry. Each new discovery broadens our understanding and opens avenues for innovative applications.


Synonyms
Isobatzelline C
133401-03-3
NSC700007
DTXSID50158101
Pyrrolo(4,3,2-de)quinolin-8(1H)-one, 7-amino-6-chloro-3,4-dihydro-1-methyl-
NSC 700007
Pyrrolo[4,3,2-de]quinolin-8(1H)-one, 7-amino-6-chloro-3,4-dihydro-1-methyl-
10-amino-9-chloro-2-methyl-2,7-diazatricyclo(6.3.1.04,12)dodeca-1(12),3,7,9-tetraen-11-one
10-amino-9-chloro-2-methyl-2,7-diazatricyclo[6.3.1.04,12]dodeca-1(12),3,7,9-tetraen-11-one
CHEMBL447517
DTXCID9080592
NSC-700007
Pyrrolo[4,2-de]quinolin-8(1H)-one, 7-amino-6-chloro-3,4-dihydro-1-