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Prochlorperazine

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Identification
Molecular formula
C20H24N3S
CAS number
58-38-8
IUPAC name
10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
State
State

At room temperature, Prochlorperazine is in a solid state.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
524.50
Boiling point (Kelvin)
797.65
General information
Molecular weight
373.53g/mol
Molar mass
373.5290g/mol
Density
1.3000g/cm3
Appearence

Prochlorperazine is typically available as a white or pale yellow crystalline powder. It is odorless or may have a slight odor.

Comment on solubility

Solubility of 10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

The solubility of the compound 10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine (C20H24N3S) is an interesting topic due to its unique structure and characteristics. This compound, being a phenothiazine derivative, exhibits varying solubility in different solvents. Here are some key points regarding its solubility:

  • Polarity: The presence of the 4-methylpiperazin-1-yl group contributes to the overall polarity of the molecule, potentially enhancing its solubility in polar solvents.
  • Solvent Compatibility: Typically, phenothiazines are more soluble in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Acetone
    • Ethyl acetate
  • Water solubility: Due to the hydrophobic nature of the phenothiazine ring, the water solubility of this compound is relatively low. However, conditions such as:
    • pH levels
    • Temperature
  • may affect its solubility in aqueous solutions.
  • Concentration Effects: At higher concentrations, solubility may decrease due to aggregation or precipitation.
  • Formulations: This compound's solubility can be improved when incorporated into formulations like:
    • Micelles
    • Emulsions

Understanding the solubility of 10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine is crucial for its potential applications and effectiveness in various fields, especially pharmacology. Overall, while it demonstrates low water solubility, it is often soluble in various organic solvents, which enhances its versatility in medicinal formulations.

Interesting facts

Interesting Facts about 10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine is a fascinating compound due to its unique structure and potential applications. Here are some intriguing insights:

  • Pharmacological Aspects: This compound is studied for its psychotropic properties, particularly in the field of psychiatry. Its structure enables it to interact with various neurotransmitter systems in the brain, potentially offering therapeutic benefits.
  • Phenothiazine Derivative: As a derivative of phenothiazine, which is known for its application in antipsychotic medications, this compound shares similar attributes that may contribute to its efficacy in treating mental health disorders.
  • Structure Activity Relationship (SAR): The introduction of the 4-methylpiperazin-1-yl group modifies the compound's lipophilicity and pharmacokinetic profile, which plays a critical role in its biological activity. Understanding these modifications is vital for the development of more effective medications.
  • Research Potential: Ongoing research is aimed at exploring this compound's effects on various conditions like schizophrenia and anxiety disorders. Its complex structure makes it a subject of interest for medicinal chemistry, where scientists strive to optimize its properties.
  • Importance of Pipers: The presence of the piperazine ring highlights the importance of such structures in drug design. This moiety is frequently found in many pharmaceuticals due to its ability to enhance receptor binding and selectivity.

In conclusion, 10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine is not only a compound of interest due to its theoretical applications but also serves as a rich topic for ongoing research in the fields of medicinal chemistry and pharmacology. As scientists continue to explore its properties, new therapeutic avenues may emerge from this intriguing compound.

Synonyms
PERAZINE
Pernazine
84-97-9
Taxilan
Psytomin
N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine
P 725
10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine
N-Methyl-piperazinyl-N'-propyl-phenothiazin
EINECS 201-578-9
DTXSID6048628
10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
CHEBI:59118
UNII-8915147A2B
Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-
PERAZINE [MI]
10-(3-(4-Methylpiperazin-1-yl)propyl)-10H-phenothiazine
10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-
PERAZINE [WHO-DD]
N-Methyl-piperazinylpropyl-phenothiazine
N-Methyl-piperazinyl-N'-propyl-phenothiazin [German]
10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
8915147A2B
DTXCID3028554
10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-
10-(3-(4-methylpiperazin-1-yl)propyl)phenothiazine
NSC638694
NCGC00159492-02
N-Methyl-piperazinyl-N'-propyl-phenothiazine
PROCHLORPERAZINE MALEATE IMPURITY B [EP IMPURITY]
10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-10H-PHENOTHIAZINE
PROCHLORPERAZINE MALEATE IMPURITY B (EP IMPURITY)
Perazin
SCHEMBL147165
CHEMBL1697766
Tox21_112970
AKOS000281842
DB12710
NSC-638694
CAS-84-97-9
NCGC00159492-03
NS00006420
C16903
SBI-0654116.0001
EN300-18544900
Q392481
US9504692, 3946