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Periciazine

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Identification
Molecular formula
C21H23N3OS
CAS number
2622-26-6
IUPAC name
10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile
State
State

Periciazine is typically a solid at room temperature.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
405.00
Boiling point (Kelvin)
678.15
General information
Molecular weight
403.55g/mol
Molar mass
403.5500g/mol
Density
1.2635g/cm3
Appearence

Periciazine appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile

The solubility of 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile (C21H23N3OS) is influenced by several factors related to its chemical structure. Here are some key points about its solubility:

  • Polarity: The presence of the -OH (hydroxy) group and the piperidine-like structure tend to increase polarity, enhancing solubility in polar solvents.
  • Solvent Compatibility: It is likely to be soluble in solvents like dimethyl sulfoxide (DMSO) or methanol due to the polar functional groups; however, it may have limited solubility in non-polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can facilitate interactions with other molecules, which may improve its overall solubility.
  • LogP Value: The partition coefficient (LogP) indicates that this compound might have moderate lipophilicity, influencing its solubility in biological systems.

In summary, while specific quantitative data on solubility might not be readily available, it is reasonable to anticipate that 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile exhibits better solubility in polar solvents owing to its structural characteristics. As always, empirical testing should be conducted to obtain precise solubility data for practical applications.

Interesting facts

Interesting Facts about 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile

10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile is a fascinating compound that belongs to the class of phenothiazines, which are widely known for their use in medicine, particularly in psychiatry. Here are some intriguing aspects of this compound:

  • Pharmacological Significance: This compound may exhibit potential pharmacological activities, influencing neurotransmitter systems in the brain. Phenothiazines are primarily known as antipsychotic medications, often utilized to treat schizophrenia and various mood disorders.
  • Structure and Functionality: The presence of the piperidine ring in its structure enhances its ability to interact with neurotransmitter receptors such as dopamine and serotonin receptors, which are critical in regulating mood and behavior.
  • Synthetic Versatility: Compounds like this can serve as a backbone for the synthesis of derivatives, allowing chemists to modify structures for enhanced efficacy or reduced side effects. This versatility has made phenothiazines a subject of extensive research for developing new therapeutics.
  • Research Applications: Beyond psychiatry, this compound's structural features may be investigated for other therapeutic potential, including its possible roles in treating conditions such as nausea, anxiety, or even certain types of cancer.
  • Multifaceted Mechanisms: The numerous substituents in this compound contribute to its multifaceted mechanisms of action, making it a subject of interest in drug discovery and development. Researchers often explore how variations in structure can affect biological activity.

In summary, 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile represents a complex intersection of organic chemistry and medicinal applications. As research continues, we may unlock more of its secrets, leading to significant medical advancements. As noted, “Chemistry is the study of transformation,” and compounds like this exemplify how chemical modifications can pave the way for innovative therapeutic solutions.

Synonyms
periciazine
PERICYAZINE
Propericiazine
2622-26-6
propericyazine
Piperocyanomazine
Neuleptil
Periciazinum
Nemactil
Neulactil
Aolept
Periciazina
Periciazine [INN]
Bayer 1409
10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
Periciazinum [INN-Latin]
Nelactil
Periciazina [INN-Spanish]
2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine
SKF 20,716
6909 RP
IC 6002
RP 8908
RP 8909
WH 7508
2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine
Propericiazine (JAN)
F.I. 6145
EINECS 220-071-3
SKF 20716
NSC-758641
RP-8909
BRN 0576739
Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine
DTXSID5045910
UNII-3405M6FD73
CHEBI:31981
PERICYAZINE [MI]
4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)-
SKF-20716
Propericiazine;RP 8909
3405M6FD73
10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
PERICYAZINE [MART.]
PROPERICIAZINE [JAN]
10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile
Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine [French]
PERICIAZINE [WHO-DD]
CHEMBL251940
DTXCID3025910
10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
NSC 758641
RP 8909SKF 20716
NCGC00095086-01
Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)-
Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxypiperidino)propyl]-
Periciazinum (INN-Latin)
Periciazina (INN-Spanish)
PERICYAZINE (MART.)
2-cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine
Neuleptyl
Neuleptil (TN)
Periciazin
Properazine
10-(3-(4-hydroxypiperidin-1-yl)propyl)phenothiazine-2-carbonitrile
10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]-
Spectrum_001614
starbld0016671
Spectrum2_001604
Spectrum3_000748
Spectrum4_000210
Spectrum5_001747
10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile
BSPBio_002336
KBioGR_000819
KBioSS_002094
DivK1c_000874
SCHEMBL148422
SPECTRUM1503936
SPBio_001607
GTPL9216
HMS502L16
KBio1_000874
KBio2_002094
KBio2_004662
KBio2_007230
KBio3_001556
NINDS_000874
HMS1922M18
Pharmakon1600-01503936
Tox21_111417
BDBM50346422
CCG-39062
EX-A11124
NSC758641
AKOS030527553
DB01608
FP45146
IDI1_000874
NCGC00095086-02
NCGC00095086-03
NCGC00095086-04
HY-14263
MS-25843
CAS-2622-26-6
SBI-0051867.P002
CS-0002963
NS00003873
D01485
F77808
EN300-18531251
SR-01000872777
Q2622907
SR-01000872777-1
BRD-K89669299-001-02-7
10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile #
220-071-3