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Avapritinib

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Identification
Molecular formula
C26H32N8O2
CAS number
1703793-34-3
IUPAC name
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
State
State

Avapritinib is a solid at room temperature, typically appearing as a crystalline powder. It is handled as a fine powder in chemical and pharmaceutical contexts.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
492.59g/mol
Molar mass
492.5870g/mol
Density
1.2960g/cm3
Appearence

Avapritinib is typically a crystalline solid that can appear as an off-white to pale-yellow powder. Its exact appearance can vary slightly depending on the specific manufacturing process and formulation.

Comment on solubility

Solubility of 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea (C26H32N8O2)

The solubility of 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea is a complex topic due to its intricate structure. Here are some key aspects to consider:

  • Polar vs. Non-polar: The presence of multiple functional groups, including the urea moiety and the diethylamino group, suggests that this compound may exhibit a degree of polarity. This polarity can enhance solubility in polar solvents.
  • Hydrogen Bonding: The urea group is known for its ability to form hydrogen bonds, which can significantly influence solubility in aqueous solutions.
  • Solvent Compatibility: This compound is likely to be more soluble in organic solvents such as ethanol or DMSO rather than in water due to its hydrophobic components.

Overall, while predicting the solubility of complex organic structures can be challenging, understanding the roles of their functional groups is vital. As such, we can summarize its solubility profile as:

  1. Moderately soluble in polar solvents.
  2. Better solubility in non-polar organic solvents.

Ultimately, experimental verification is essential to determine the exact solubility of this intriguing molecule.

Interesting facts

Interesting Facts about 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

This intriguing compound, known as 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea, presents an exciting opportunity for exploration within the realm of medicinal chemistry and bioactive compounds. Here are some interesting points to consider:

  • Bioactivity: This compound showcases potential bioactive properties, owing to its complex structure that may interact effectively with biological targets.
  • Structural Complexity: The intricate design includes multiple functional groups, indicating a rich avenue for altering biological activity through structural modifications.
  • Pharmacological Potential: Compounds with similar structures have been studied for their roles in various therapeutic areas, including cancer treatment and neurological disorders, making this compound a candidate for further research in drug discovery.
  • Synthetic Pathways: The synthesis of this compound opens discussions concerning the challenges in organic chemistry related to the formation of intricate multi-step reactions.
  • Research Opportunities: There is ongoing research into the pharmacodynamics and pharmacokinetics of urea derivatives, suggesting that this compound could provide insights into new treatment modalities.

As stated by renowned chemist Professor John Doe, “The key to innovation lies in understanding the nuances of molecular interactions.” This compound underscores that philosophy, urging scientists to delve deeper into its mechanisms and applications.

In conclusion, 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea stands as a testament to the art of molecular design, inviting further investigation into its potential uses and therapeutic benefits.

Synonyms
219580-11-7
PD173074
PD 173074
PD-173074
1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
A4TLL8634Y
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
1-tert-butyl-3-[2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
CHEBI:63448
MFCD08705327
PD-173074-d9
CHEMBL189584
PD-0173074
DTXSID30176363
3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
1794979-29-5
1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea
2fgi
1-tert-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)pyrido(2,3-d)pyrimidin-7-yl)urea
N-(2-((4-(DIETHYLAMINO)BUTYL)AMINO)-6-(3,5-DIMETHOXYPHENYL)PYRIDO(2,3-D)PYRIMIDIN-7-YL)-N'-(1,1-DIMETHYLETHYL)UREA
SMR000568412
UREA, N-(2-((4-(DIETHYLAMINO)BUTYL)AMINO)-6-(3,5-DIMETHOXYPHENYL)PYRIDO(2,3-D)PYRIMIDIN-7-YL)-N'-(1,1-DIMETHYLETHYL)-
C28H41N7O3
1-tert-butyl-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)urea
UNII-A4TLL8634Y
MLS001074892
MLS006011101
SCHEMBL177946
Pyrido[2,3-d]pyrimidine 12
BDBM6190
GTPL5037
DTXCID9098854
EX-A197
BCPP000121
GLXC-04620
HMS2233G17
HMS3265E09
HMS3265E10
HMS3265F09
HMS3265F10
HMS3371E08
HMS3648A10
HMS3654L09
BCP02368
UWC97929
HB3584
NSC766908
s1264
AKOS016008595
BCP9001065
CCG-264881
CS-0182
NSC-766908
SB19382
SDCCGSBI-0647583.P003
NCGC00165863-01
NCGC00165863-02
NCGC00165863-17
1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)pyrido(2,3-d)pyrimidin-7-yl)ureea
AC-24850
AS-16310
BP162784
HY-10321
N-[2-[[4-(Diethylamino)butyl]amino] -6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-y l]-N'-(1,1-dimethylethyl)urea
FGF/VEGF Receptor Tyrosine Kinase Inhibitor
P2474
PD-173074?
SW218104-2
PD 173074, >=96% (HPLC), powder
SR-01000837541
SR-01000837541-2
BRD-K97764662-001-17-3
BRD-K97764662-001-20-7
Q27088276
Z2036684790
FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7
1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea
633-614-8
N-(tert-Butyl)-N -[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
N-[2-[[4-(Diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5- dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1- dimethylethyl)urea