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1-phenylpyrazolo[3,4-d]pyrimidin-4-amine

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Identification
Molecular formula
C12H9N5
CAS number
27512-68-3
IUPAC name
1-phenylpyrazolo[3,4-d]pyrimidin-4-amine
State
State

1-Phenylpyrazolo[3,4-d]pyrimidin-4-amine is generally found as a solid at room temperature. It is stable under normal conditions and does not exhibit volatility.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
224.24g/mol
Molar mass
224.2410g/mol
Density
1.3000g/cm3
Appearence

1-Phenylpyrazolo[3,4-d]pyrimidin-4-amine is typically found as a crystalline powder. The color may range from white to pale yellow, depending on purity and form.

Comment on solubility

Solubility of 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine (C12H9N5)

The solubility of 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine can be influenced by numerous factors due to its unique chemical structure. This compound exhibits a relatively low solubility in water, which is a common trait among many nitrogen-containing heterocycles. Here are some key points to consider:

  • Polarity: The presence of multiple nitrogen atoms may contribute to moderate polarity; however, the overall structure limits its interaction with water.
  • Organic Solvents: This compound tends to be more soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone.
  • pH Dependency: The solubility may vary significantly with pH, particularly if ionization occurs under acidic or basic conditions.
  • Temperature Impact: Increasing temperature usually enhances the solubility of organic compounds, making this an important consideration.

In conclusion, while 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine is relatively insoluble in water, it finds better solubility in organic solvents. As a result, researchers often need to take into account the solubility profile when designing experiments or pharmaceutical formulations.

Interesting facts

Interesting Facts about 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine

1-phenylpyrazolo[3,4-d]pyrimidin-4-amine is a fascinating compound belonging to the class of heterocyclic compounds, specifically pyrimidines. Here are some intriguing insights about this compound:

  • Antitumor Activity: This compound has emerged as a candidate in cancer research, illustrating potential antitumor properties that warrant further investigation.
  • Pharmacological Significance: The unique molecular structure of 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine offers opportunities for medicinal chemistry, particularly in developing new drugs targeting various diseases.
  • Potential Kinase Inhibitor: It has been noted for its ability to inhibit certain kinases, which play critical roles in cellular signaling and cancer progression.
  • Research Interest: The compound has garnered attention within the scientific community, making it a subject of many studies aimed at understanding its biological activity and therapeutic potentials.
  • Structure-Activity Relationship (SAR): Researchers are keen to explore the SAR of this compound, which can lead to tailored modifications that enhance its efficacy and specificity.

As with many compounds in medicinal chemistry, the journey of 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine into effective therapy highlights the importance of understanding not just its chemical properties, but also its interaction with biological systems. As stated by a prominent researcher, “The key to unlocking new therapies often lies within the structures of these complex compounds.”
The ongoing research into this compound presents an exciting frontier for the next generation of pharmacology!

Synonyms
5334-30-5
4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine
1-phenyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine
PP 3
1-phenylpyrazolo[3,4-d]pyrimidin-4-amine
pp3
CHEMBL65063
C11H9N5
1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
4-Amino-1-phenylpyrazolo(3,4-e)pyrimidine
4-AMINO-1-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE
1H-Pyrazolo[3,4-d]pyrimidine, 4-amino-1-phenyl-; NSC 1401
4-Amino-1-phenylpyrazolo(3,4-d)pyrimidine
SBB028425
NSC1401
MFCD00022901
cid_4879
Oprea1_329529
Oprea1_457349
MLS000054252
GTPL6029
SCHEMBL2278510
CHEBI:92303
DTXSID20274448
HMS2502N08
HMS3229K03
NSC-1401
BDBM50013720
HB1336
HSCI1_000188
STL356148
AKOS000536351
CCG-206781
ES-0020
SDCCGSBI-0086701.P003
NCGC00037167-02
SMR000065878
DB-052309
HY-108484
CS-0028960
NS00016555
pyrazolo[3,4-d]pyrimidine, 4-amino-1-phenyl-
T71017
EN300-1644893
AE-641/02360026
1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine #
BRD-K16977723-001-01-0
Q27088431
Z56801548
808-056-5