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Proline

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Identification
Molecular formula
C5H9NO2
CAS number
147-85-3
IUPAC name
1-methylpyrrolidine-2-carboxylic acid
State
State
Proline is typically a solid at room temperature, appearing as a crystalline powder. It remains stable and is widely used in scientific research and industry.
Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
115.13g/mol
Molar mass
115.1300g/mol
Density
1.3500g/cm3
Appearence

Proline typically appears as a white crystalline powder under standard conditions. It is often found in its pure form in the laboratory as a reagent in chemical and biochemical applications.

Comment on solubility

Solubility of 1-methylpyrrolidine-2-carboxylic acid (C5H9NO2)

1-methylpyrrolidine-2-carboxylic acid is a fascinating compound that exhibits interesting solubility properties. Understanding the solubility of this compound is vital for its application in various fields, as solubility can influence chemical reactivity, bioavailability, and effectiveness. Here are some critical points regarding its solubility:

  • Highly Soluble in Polar Solvents: 1-methylpyrrolidine-2-carboxylic acid tends to be highly soluble in polar solvents such as water and alcohols. This is primarily due to the presence of the carboxylic acid functional group, which can engage in hydrogen bonding.
  • Moderate Solubility in Non-Polar Solvents: In contrast, its solubility in non-polar solvents is considerably lower, reflecting the compound's polar characteristics. The hydrophobic 1-methylpyrrolidine ring limits its interaction with non-polar solvents.
  • Temperature Dependence: The solubility may vary with temperature, with increased temperature generally enhancing the solubility of many compounds, including 1-methylpyrrolidine-2-carboxylic acid.
  • pH Influence: The solubility of this compound can also be influenced by pH levels, particularly due to the presence of the carboxylic acid. At lower pH, the compound may exist primarily in its protonated form, affecting solubility in different environments.

In summary, 1-methylpyrrolidine-2-carboxylic acid is soluble in polar solvents due to its polar functional groups, while exhibiting limited solubility in non-polar environments. Understanding these solubility characteristics is crucial for its practical applications in chemical synthesis and pharmaceuticals.

Interesting facts

Interesting Facts about 1-Methylpyrrolidine-2-carboxylic Acid

1-Methylpyrrolidine-2-carboxylic acid, often referred to as an interesting derivative in the realm of organic chemistry, has a variety of intriguing properties and applications. Here are some notable points:

  • Structure and Functionality: This compound features a pyrrolidine ring that contributes to its unique chemical reactivity. The methyl group provides additional steric hindrance, influencing how it interacts with other molecules.
  • Synthesis: 1-Methylpyrrolidine-2-carboxylic acid can be synthesized through various methods. One common approach is the reaction of pyrrolidine derivatives with carboxylic acids, showcasing the versatility of organic synthesis techniques.
  • Biochemical Implications: Compounds with similar structures often find roles in biochemical pathways. They can act as building blocks for more complex molecules, including pharmaceuticals and agrochemicals, making them highly relevant in medicinal chemistry.
  • Potential Applications: The derivative may be investigated for its potential use in drug development, particularly in creating new analgesics or muscle relaxants due to the presence of the carboxylic acid functional group.
  • Research Opportunities: There are numerous research opportunities involving this compound, especially in studying its potential interactions with biological systems and how it might enhance or inhibit certain biochemical processes.

In summary, 1-methylpyrrolidine-2-carboxylic acid represents a fascinating intersection of structure, function, and application in organic chemistry. As researchers explore this compound further, we can anticipate exciting discoveries that may contribute to various fields, including pharmacology and biochemistry.

Synonyms
1-methylpyrrolidine-2-carboxylic acid
68078-09-1
1-Methyl-pyrrolidine-2-carboxylic acid
1-Methylproline
1-Methyl-DL-proline
proline, 1-methyl-
N-Me-Pro-OH
N-methylproline
DTXSID10274275
methylproline
METHYL-D-PROLINE
D-Proline, 1-methyl-
L-Proline, 1-methyl-
MFCD00011565
1-Methylproline #
MFCD01605583
n-methyl-(l)-proline
N-methyl-D,L-proline
SCHEMBL145545
1-methylpyrrolidine-2-carboxylate
DTXCID40225755
ALBB-016470
CS-B1576
NSC45492
1-methylpyrrolidine-2-carboxylicacid
NSC-45492
XH1270
N-Methylpyrrolidine-2-carboxylic acid
AKOS004910667
SB13701
SB13702
SB13703
SDCCGMLS-0064715.P001
BS-13089
SY004606
SY004607
DB-072429
EN300-60915
Q3596761
Z424762078
836-213-8