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Nicotinic acid

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Identification
Molecular formula
C6H5NO2
CAS number
59-67-6
IUPAC name
1-methylpyridin-1-ium-3-carboxylic acid
State
State

At room temperature, nicotinic acid is typically a solid. It is stable under standard conditions and can be easily handled in a typical laboratory environment.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
236.00
Boiling point (Kelvin)
509.15
General information
Molecular weight
139.11g/mol
Molar mass
139.1110g/mol
Density
1.4730g/cm3
Appearence

Nicotinic acid, commonly referred to as niacin, appears as a white crystalline solid. It is known for its high purity and characteristic crystalline structure that is typically easy to recognize. It is also odorless and has a slightly acidic taste.

Comment on solubility

Solubility of 1-Methylpyridin-1-ium-3-carboxylic Acid

1-Methylpyridin-1-ium-3-carboxylic acid, with the chemical formula C6H5NO2, exhibits interesting solubility characteristics due to its structural features. This compound is known to be soluble in polar solvents such as water, owing to the presence of both a polar carboxylic acid group and a positively charged nitrogen atom in its pyridinic ring. The overall solubility can be attributed to the following factors:

  • Hydrogen Bonding: The carboxylic acid group can form hydrogen bonds with water molecules, enhancing solubility.
  • Ionization: In aqueous solutions, the compound can ionize, further increasing its solubility due to the formation of charged species.
  • Charge Distribution: The presence of a positively charged nitrogen creates a dipole that can interact favorably with polar solvents.

As a result, one may conclude that 1-methylpyridin-1-ium-3-carboxylic acid is notably soluble in water and may also show solubility in other polar organic solvents. However, its solubility in non-polar solvents would be significantly lower due to the lack of favorable interactions.

In summary, this compound demonstrates how the presence of functional groups and molecular charge can drastically affect solubility properties. As the saying goes, "Like dissolves like," and in this case, the compound's structure aligns favorably with the properties of polar solvents.

Interesting facts

Interesting Facts about 1-methylpyridin-1-ium-3-carboxylic acid

1-methylpyridin-1-ium-3-carboxylic acid, often simply referred to as a pyridinium compound, is a fascinating addition to the world of organic chemistry. Here are some intriguing aspects of this compound:

  • Unique Structure: The presence of the pyridinium ion is indicative of how this compound behaves in aqueous solutions, contributing to its solubility and reactivity.
  • Biological Relevance: Compounds in the pyridine family often show **pharmacological activity**. This one is no exception, as derivatives of pyridine are frequent candidates in drug design.
  • Industrial Applications: The functional groups such as the carboxylic acid moiety allow this compound to participate in various chemical reactions, making it useful in organic synthesis and potentially in the formulation of various chemicals.
  • Research Potential: As scientists explore the properties of 1-methylpyridin-1-ium-3-carboxylic acid, they uncover its potential roles in catalysis and materials science, especially in the development of new, more efficient catalysts.
  • Hydrogen Bonding: The presence of both the pyridinium and carboxylic acid functional groups can lead to unique **hydrogen bonding capabilities**, making it a subject of interest in the study of molecular interactions.

As Charles Darwin once said, "It is not the strongest of the species that survive, nor the most intelligent, but the one most responsive to change." In a similar vein, observing the reactivity and adaptability of compounds like 1-methylpyridin-1-ium-3-carboxylic acid showcases the dynamic nature of organic chemistry, pushing the boundaries of what we can achieve with such molecules.

This compound serves as a reminder of the importance of **pyridine derivatives** in both traditional and modern chemistry, making it a worthy subject of study for any chemistry enthusiast!

Synonyms
N-Methylnicotinic acid
3-carboxy-1-methylpyridinium
1-methylpyridin-1-ium-3-carboxylic acid
7164-65-0
CHEBI:50521
SR-01000838861
Spectrum_000771
SpecPlus_000541
Prestwick3_000593
Spectrum2_000596
Spectrum3_000791
Spectrum4_001659
Spectrum5_000537
TRIGONELLINE_met003
bmse000152
NCIOpen2_003241
BSPBio_000466
BSPBio_002522
KBioGR_002157
KBioSS_001251
DivK1c_006637
SCHEMBL679317
SPBio_000472
BPBio1_000514
CHEMBL1187085
KBio1_001581
KBio2_001251
KBio2_003819
KBio2_006387
KBio3_001742
WWNNZCOKKKDOPX-UHFFFAOYSA-
DTXSID10859465
3-Carboxy-1-methylpyridin-1-ium
s3220
AC-907/25004677
AH-232/03153019
SR-01000838861-3
SR-01000838861-4
BRD-K69231085-003-05-7
Q27122098
Pyridinium, 3-carboxy-1-methyl-, hydroxide, inner salt (8CI)
110407F8-19F1-4E98-9925-6B225E677E75
InChI=1/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3/p+1