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Nicotine

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Identification
Molecular formula
C10H14N2O
CAS number
54-11-5
IUPAC name
1-methyl-5-(2-pyridyl)pyrrolidin-2-one
State
State

At room temperature, nicotine is commonly in a liquid state. Its properties allow it to evaporate readily, giving it a tendency to exist as a vapor in the air under certain conditions.

Melting point (Celsius)
-79.00
Melting point (Kelvin)
194.15
Boiling point (Celsius)
247.00
Boiling point (Kelvin)
520.15
General information
Molecular weight
162.23g/mol
Molar mass
162.2340g/mol
Density
0.9961g/cm3
Appearence

Nicotine is a colorless to pale yellow, oily liquid. It is hygroscopic and miscible with water in its base form. Nicotine tends to have a characteristic “tobacco” smell and turns brown on exposure to air.

Comment on solubility

Solubility of 1-methyl-5-(2-pyridyl)pyrrolidin-2-one (C10H14N2O)

1-methyl-5-(2-pyridyl)pyrrolidin-2-one, a compound with a complex structure, exhibits intriguing solubility characteristics. This solubility can be influenced by a variety of factors including polarity, molecular interactions, and the presence of functional groups.

Key Factors Affecting Solubility:

  • Polarity: The presence of the hydroxyl group (–OH) in the structure enhances the polarity of the molecule, contributing to its solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can significantly increase its solubility in aqueous environments.
  • Functional Groups: The pyridine ring in 1-methyl-5-(2-pyridyl)pyrrolidin-2-one may engage in interactions with solvents, further influencing solubility.

Typically, this compound is expected to be:

  • Soluble in polar organic solvents such as methanol, ethanol, and warm water.
  • Less soluble or insoluble in non-polar solvents due to its polar characteristics stemming from the functional groups.

In conclusion, the solubility of 1-methyl-5-(2-pyridyl)pyrrolidin-2-one is a result of a delicate balance between its molecular structure and solvent properties. As a rule of thumb, “like dissolves like,” indicating that this compound will find greater affinity in polar environments.

Interesting facts

Interesting Facts about 1-methyl-5-(2-pyridyl)pyrrolidin-2-one

1-methyl-5-(2-pyridyl)pyrrolidin-2-one is a fascinating compound that holds significance in various fields, particularly in medicinal chemistry and drug design. Here are some intriguing insights:

  • Structural Features: This compound is part of the pyrrolidine family, which is known for its unique five-membered ring structure. The presence of a methyl group at the nitrogen position enhances the compound's stability and reactivity.
  • Biological Activity: 1-methyl-5-(2-pyridyl)pyrrolidin-2-one has been investigated for its potential therapeutic applications. Compounds in this class may exhibit activities such as neuroprotection and modulation of neurotransmitter systems.
  • Research Applications: The presence of a pyridine ring in this compound opens avenues for research into its interactions with biological receptors, specifically in areas related to cognitive function and mood regulation.
  • Potential Drug Development: This compound could serve as a lead for developing novel pharmaceuticals targeting various neurological disorders, making it a compound of interest in ongoing research.
  • Synthetic Routes: The synthesis of 1-methyl-5-(2-pyridyl)pyrrolidin-2-one involves innovative approaches that highlight the importance of organic synthesis techniques in creating complex molecular structures.

As the understanding of chemical compounds expands, studying 1-methyl-5-(2-pyridyl)pyrrolidin-2-one can lead to exciting breakthroughs in both academia and industry. Its versatility and potential make it a noteworthy subject of study for both chemists and pharmacologists alike.

Synonyms
147732-31-8
1-methyl-5-(pyridin-2-yl)pyrrolidin-2-one
(+/-)-ortho-Cotinine
(+/-)-O-Cotinine
1-methyl-5-pyridin-2-ylpyrrolidin-2-one
2-Pyrrolidinone, 1-methyl-5-(2-pyridinyl)-
(R,S)-ortho-Cotinine
1-Methyl-5-(2-pyridyl)-2-pyrrolidinone
SCHEMBL8013321
CHEMBL3126029
DTXSID00274300
MFCD01320387
AKOS027384634
1-methyl-5-(2-pyridyl)-pyrrolidinone
CS-0446963