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1-Hydroxypyridine-2(1H)-thione

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Identification
Molecular formula
C5H5NOS
CAS number
1121-31-9
IUPAC name
1-hydroxypyridine-2-thione
State
State

At room temperature, 1-Hydroxypyridine-2-thione exists as a solid.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
279.30
Boiling point (Kelvin)
552.45
General information
Molecular weight
127.17g/mol
Molar mass
127.1670g/mol
Density
1.4000g/cm3
Appearence

1-Hydroxypyridine-2-thione appears as a solid compound. It is generally a white to pale yellow crystalline powder. The powder has a distinct but faint odor and is often used in various applications for its antimicrobial properties, particularly in the control of dandruff.

Comment on solubility

Solubility of 1-hydroxypyridine-2-thione (C5H5NOS)

1-hydroxypyridine-2-thione, commonly referred to as a thione derivative, exhibits notable solubility characteristics that merit consideration. This compound is particularly known for its solubility in various organic solvents, which can be pivotal for its applications in chemical synthesis and pharmaceutical formulations.

Key Solubility Insights:

  • Polar Solvents: 1-hydroxypyridine-2-thione is typically soluble in polar solvents such as water and ethanol, owing to its hydroxyl group that enhances its hydrogen bonding capabilities.
  • Non-polar Solvents: It also shows some degree of solubility in non-polar solvents, although this may be limited compared to its solubility in polar environments.
  • pH Influence: The solubility can be influenced by the pH of the solution; the protonation state of the nitrogen atom can affect how well the compound interacts with solvents.

In summary, the solubility of 1-hydroxypyridine-2-thione is a crucial feature that impacts its versatility in various chemical processes. Understanding these solubility properties can lead to better utilization in fields such as medicinal chemistry and materials science. Overall, the behavior of this compound in different solvents highlights the importance of functional groups in determining solubility.

Interesting facts

Interesting Facts about 1-Hydroxypyridine-2-thione

1-hydroxypyridine-2-thione, a fascinating compound in the realm of heterocyclic chemistry, showcases the intriguing interplay between nitrogen, sulfur, and oxygen within its structure. Here are some compelling aspects of this compound:

  • Bioactivity: This compound is known for its diverse biological activities, which include antimicrobial and potentially antifungal properties, making it a subject of interest in pharmaceutical research.
  • Coordination Chemistry: 1-hydroxypyridine-2-thione acts as a bidentate ligand, capable of forming stable complexes with transition metals. This feature is vital in catalytic processes and material science.
  • Synthesis Versatility: The compound can be synthesized through various methods, often involving the modification of pyridine derivatives. Its versatility in synthesis opens up pathways for tailored functionalizations.
  • Analytical Applications: Its unique functional groups allow for its use in analytical techniques, particularly in the detection of metal ions, due to its chelating abilities.
  • Research Relevance: Ongoing studies explore its role in developing new materials and chemical sensors, highlighting its significance in contemporary chemistry.

The study of 1-hydroxypyridine-2-thione not only enhances our understanding of pyridine chemistry but also underscores the importance of sulfur-containing compounds in biological and industrial applications. As a student or scientist, one might find that the synergy of its properties provides a fertile ground for innovation and discovery.

Synonyms
pyrithione
1121-31-9
2-MERCAPTOPYRIDINE-N-OXIDE
2-mercaptopyridine n-oxide
1121-30-8
Omadine
2-Pyridinethiol 1-oxide
1-Hydroxyl-1H-pyridine-2-thione
1-Hydroxy-2-pyridinethione
1-hydroxypyridine-2-thione
1-hydroxypyridine-2(1H)-thione
1-Hydroxy-2(1H)-pyridinethione
2-Pyridinethiol, 1-oxide
N-Hydroxypyridine-2-thione
Pyridine-2-thiol N-oxide
2-Mercaptopyridine monoxide
SQ 2113
1-Hydroxy-2-(1H)-pyridinethione
2-MERCAPTOPYRIDINE 1-OXIDE
pyridinethiol n-oxide
2(1H)-Pyridinethione, 1-hydroxy-
EINECS 214-328-9
EINECS 214-329-4
UNII-6GK82EC25D
MFCD00006196
NSC 179790
NSC-179790
BRN 0109936
BRN 0906983
6GK82EC25D
CHEBI:36578
AI3-60234
2-(1H)-Pyridinethione, 1-hydroxy-
pyridine-2-thiol 1-oxide
1-oxidanylpyridine-2-thione
2-SULFANYLPYRIDIN-1-IUM-1-OLATE
MLS001335994
CHEMBL1356238
CHEBI:36584
DTXSID00149908
5-21-07-00150 (Beilstein Handbook Reference)
MFCD00059791
NSC179790
SMR000814708
2-HPT cpd
1-hydroxy-1H-pyridine-2-thione
Pyridine-2-thiol-1-oxide
BEW
1-hydroxy-1,2-dihydropyridine-2-thione
2-Pyridinethiol1-oxide
2-ercaptopyridine--xide
mercaptopyridine-1-oxide
PYRITHIONE [MI]
2-pyridinethiol-N-oxide
2-Thiopyridine-N-oxide-
mercapto pyridine-1-oxide
2-mercaptopyridine-1-oxid
2mercapto pyridine N-oxide
cid_1570
WLN: T6NYJ AQ BUS
2-mercapto pyridine N-oxide
2-mercapto-pyridine-N-oxide
PYRITHIONE [WHO-DD]
2-mercapto-pyridine-1-oxide
SCHEMBL24755
SCHEMBL49266
MLS001335993
1-oxidopyridin-1-ium-2-thiol
CHEMBL1650619
DTXCID1072399
DTXSID4048010
BDBM60985
YBBJKCMMCRQZMA-UHFFFAOYSA-
1-Oxido-2-pyridinyl hydrosulfide
pyridine, 1-oxide, 2-mercapto-
FGVVTMRZYROCTH-UHFFFAOYSA-N
HMS1772L20
2-Mercaptopyridine N-oxide, 99%
HY-B1747
BBL104003
BDBM50366038
STL557814
pyridine-2(1H)-thione, 1-hydroxy-
AKOS001147723
AKOS006239794
AB00615
DB06815
FM38212
SB21519
NCGC00246995-01
AS-10952
DA-57273
FH175788
LS-13036
SY245984
pyridine, 1,2-dihydro-1-hydroxy-2-thio-
DB-038047
CS-0013767
H0302
NS00003475
NS00014197
EN300-18970
D78428
G12162
A802495
A802496
Q2119951
Q27116892
InChI=1/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,7H