Skip to main content

Cotinine

ADVERTISEMENT
Identification
Molecular formula
C10H12N2O
CAS number
486-56-6
IUPAC name
1-(hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one
State
State

At room temperature, cotinine exists as a solid.

Melting point (Celsius)
121.00
Melting point (Kelvin)
394.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
176.22g/mol
Molar mass
176.2170g/mol
Density
1.1230g/cm3
Appearence

Cotinine appears as a yellow-white crystalline solid.

Comment on solubility

Solubility of 1-(hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one

The solubility of 1-(hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one (C10H12N2O) is an important property to consider, particularly in the context of its applications in pharmaceuticals and organic synthesis. Here are some key points to understand its solubility characteristics:

  • Polar Nature: This compound contains a hydroxymethyl group and a pyridine ring, which contributes to its overall polarity. The presence of the hydroxyl group typically increases the solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of the hydroxymethyl group to engage in hydrogen bonding enhances its solubility in polar solvents. This interaction often facilitates greater dissolution in aqueous environments.
  • Solubility in Organic Solvents: Additionally, 1-(hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one is likely to be soluble in a range of organic solvents, including alcohols and dimethyl sulfoxide (DMSO), which can stabilize its structure through nonpolar interactions.
  • pH Dependency: It is also essential to consider that the solubility can be pH-dependent, as changes in the ionic state of the functional groups may alter its solubility profile.

In summary, the solubility of 1-(hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one can be characterized by its polar structural components and potential for hydrogen bonding, making it soluble in both polar and nonpolar solvents with a likely dependence on the surrounding pH conditions.

Interesting facts

Interesting Facts about 1-(Hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one

1-(Hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one is a fascinating compound that showcases the complexity and diversity of organic chemistry. Here are some intriguing details about its structure and potential applications:

  • Structural Influence: The presence of both a pyrrolidine ring and a pyridine moiety makes this compound a prime example of how different ring systems can be combined to create unique chemical properties. This hybrid structure may influence its reactivity and biological interactions.
  • Potential Pharmacological Applications: Compounds containing pyridine and pyrrolidine rings have been studied for various biological activities, including antiviral and anticancer properties. One could hypothesize that this compound might have valuable effects in medicinal chemistry.
  • Hydroxymethyl Group: The hydroxymethyl (-CH₂OH) functional group can enhance solubility and biological activity, possibly making this compound a subject of interest in drug design.
  • Research Potential: The unique combination of functional groups in this compound offers numerous avenues for research, such as synthesizing analogs for optimizing biological activity or studying interaction pathways within living organisms.

In conclusion, 1-(Hydroxymethyl)-5-(3-pyridyl)pyrrolidin-2-one is more than just a chemical entity; it symbolizes how innovation in compound designs can lead to the discovery of new pharmaceuticals and further our understanding of chemical biology. As renowned scientist Linus Pauling once said, "The greatest advances of civilization, whether in architecture or in engineering, or in any other field, have been the result of the ability to improvise."

Synonyms
N'- Hydroxymethyl- norcotinine
NS00115017