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TEMPOL

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Identification
Molecular formula
C9H18N1O2
CAS number
2226-96-2
IUPAC name
1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol
State
State

At room temperature, TEMPOL is a solid solid, generally appearing as crystalline in form. It remains stable under ambient conditions and is frequently used in solid form in laboratory settings.

Melting point (Celsius)
70.00
Melting point (Kelvin)
343.15
Boiling point (Celsius)
153.00
Boiling point (Kelvin)
426.15
General information
Molecular weight
172.25g/mol
Molar mass
172.2510g/mol
Density
1.0191g/cm3
Appearence

TEMPOL is a crystalline solid that is typically colorless. It may appear in white or pale-yellow crystals and is known to be hygroscopic, which means it can absorb moisture from the air, leading to a change in its appearance.

Comment on solubility

Solubility of 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol

The solubility of 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol (C9H18N1O2) is influenced by several factors, primarily due to its chemical structure. This compound is characterized by a hydroxyl group and a bulky piperidine ring, which has implications for its interactions with solvents.

Here are key points regarding its solubility:

  • Polar Characteristics: The presence of the hydroxyl group contributes to a degree of polarity, which can enhance solubility in polar solvents such as water.
  • Hydrophobic Elements: The tetramethyl groups on the piperidine ring introduce hydrophobic characteristics, potentially limiting solubility in water.
  • Organic Solubility: The compound is more likely to be soluble in organic solvents (e.g., ethanol, methanol, or acetone) due to its hydrophobic regions making favorable interactions with non-polar environments.
  • Temperature Factors: Like many organic compounds, solubility can vary significantly with temperature; increased temperatures may enhance solubility in organic solvents.

In conclusion, while 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol may show *modest* solubility in water due to its polar functionalities, its more significant solubility is expected in organic solvents owing to its structure. Understanding these solubility properties is crucial when considering its practical applications in various chemical environments.

Interesting facts

Interesting Facts about 1-Hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol

1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol, often abbreviated as TMPH, is a fascinating compound widely recognized for its role as a potent antioxidant. Here are some intriguing aspects of this compound:

  • Antioxidant Activity: TMPH is known for its ability to scavenge free radicals, which makes it highly valuable in various industrial applications and in the field of medicine. Free radicals are notorious for contributing to oxidative stress in biological systems, and substances like TMPH can help mitigate this damage.
  • Stabilizer in Polymers: The compound is often utilized as a stabilizer in plastic products, enhancing their longevity by protecting them from degradation due to environmental factors.
  • Mechanism of Action: The unique piperidin-4-ol structure of TMPH allows it to interact effectively with radical species, making it an efficient scavenging agent. This reactivity is attributed to the presence of the hydroxyl group, which plays a critical role in its antioxidant properties.
  • Applications in Pharmaceuticals: Due to its antioxidative properties, TMPH is explored in drug formulations, particularly in products designed to combat oxidative damage associated with aging and certain diseases.
  • Research Potential: Ongoing research continues to uncover new potential applications and derivatives of TMPH, with scientists examining its effects on cellular processes and its potential in developing new therapeutic agents.

In summary, 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol is not just a simple compound; it embodies a blend of chemical intrigue with a wide array of practical applications, supporting both industrial innovations and advancements in health science.

Synonyms
3637-10-3
4-Piperidinol, 1-hydroxy-2,2,6,6-tetramethyl-
TEMPOL-H
2,2,6,6-tetramethylpiperidine-1,4-diol
1,4-dihydroxy-2,2,6,6-tetramethylpiperidine
Tempol H
OT-674
1-hydroxy-2,2,6,6-tetramethylpiperidin-4-ol
V55XB6IT82
1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinol
OT 674
1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-ol
4-hydroxy-2,2,6,6-tetramethyl-n-hydroxypiperidine
Tempol (4-Hydroxy-TEMPO)
N-Hydroxy-2,2,6,6-tetramethylpiperidine
DTXSID40859711
4-hydroxy-2,2,6,6-tetramethyl-1-hydroxypiperidine
4-hydroxy-TEMPOL
HOTMP
TEMPO-H
4-hydroxy tempo
4h-tempo
Tempol hydroxylamine
2,2,6,6-TETRAMETHYL-4-HYDROXY-1-PIPERIDINYLOXY
HO-TEMPO
UNII-V55XB6IT82
SCHEMBL23902
CHEMBL117649
DTXCID80209756
HMS3651B10
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical
NSC142784
STK246905
AKOS006228301
FT02559
PB47762
[O]N1C(C)(C)CC(O)CC1(C)C
4-Hydroxy-2,6,6-tetramethylpiperidinooxy
NCI60_000934
PS-15551
SY002737
2,6,6-Tetramethyl-4-piperidinol 1-oxide
2,2,6,6-Tetramethyl-piperidine-1,4-diol
1-oxyl-2,2,6,6-tetramethylpiperidin-4-ol
NS00007979
SW219557-1
4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl
1,4-dihydroxy-2,2,6,6-tetramethyl-piperidine
2,6,6-Tetramethyl-4-hydroxypiperidine 1-oxide
4-Hydroxy-2,6,6-tetramethylpiperidine N-oxide
D71066
E83391
1-oxyl-2,2,6,6-tetramethyl4-hydroxypiperidine
1-oxyl-4-hydroxy-2,2,6,6-tetramethylpiperidine
4-hydroxy-2,2,6,6-tetramethylpiperidin-n-oxyl
4-hydroxy-2,2,6,6-tetramethylpiperidine n-oxyl
4hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine
2,6,6-Tetramethyl-4-hydroxypiperidinooxy radical
4-hydroxy-2,2,6,6-tetramethyl-piperdine-N-oxyl
4-Hydroxy-2,6,6-tetramethylpiperidinooxy radical
4-hydroxyl-1-oxyl-2,2,6,6-tetramethylpiperidine
4-Piperidinol, 2,2,6,6-tetramethyl-, 1-oxide
piperidine, 1,4-dihydroxy-2,2,6,6-tetramethyl-
1-hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidine
Q4637150
BRD-K95053546-001-01-9
BRD-K95053546-001-02-7
BRD-K95053546-001-03-5
Q27291546
2,2,6,6-Tetramethyl-4-piperidinol 1-oxyl, free radical
4-Hydroxy TEMPO;4-Oxypiperidol;Tempol;4-Hydroxy-2,2,6,6-tetramethylpiperidine N-oxide
434-880-6