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Taxol (Paclitaxel)

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Identification
Molecular formula
C47H51NO14
CAS number
33069-62-4
IUPAC name
1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione
State
State

At room temperature, Taxol is a solid, specifically a crystalline powder.

Melting point (Celsius)
213.50
Melting point (Kelvin)
486.65
Boiling point (Celsius)
790.00
Boiling point (Kelvin)
1 063.15
General information
Molecular weight
853.91g/mol
Molar mass
853.9060g/mol
Density
1.6600g/cm3
Appearence

Taxol, or Paclitaxel, appears as a white to off-white crystalline powder. It is practically insoluble in water, soluble in alcohol, and in most organic solvents such as chloroform, acetone, and dichloromethane.

Comment on solubility

Solubility of 1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione

The compound 1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione, with the chemical formula C47H51NO14, presents an intriguing case regarding its solubility characteristics. Due to its complex structure and significant molecular weight, the solubility of this compound is influenced by several factors:

  • Polarity: The presence of multiple hydroxy groups suggests that the compound may exhibit polar characteristics, potentially enhancing its solubility in polar solvents like water.
  • Molecular Size: With a high molecular weight (47 carbon atoms), the size can hinder solubility in non-polar solvents, limiting the range of compatible solvents.
  • Functional Groups: The number and type of functional groups, specifically the hydroxyl (-OH) groups, may facilitate hydrogen bonding, promoting solubility in suitable solvents.

As a general observation, compounds with high molecular complexity and substantial numbers of polar functional groups often demonstrate interesting solubility profiles. It is essential to conduct experimental analyses to determine the precise solubility behavior of this particular compound under varying pH and solvent conditions. As we note:

"Solubility is not just a property; it is a window into the molecular interactions of a compound."

While definitive solubility data may be limited, it is crucial to explore and establish the conditions under which this compound may dissolve. Understanding these properties could prove valuable for applications in various fields, including pharmaceuticals and material science.

Interesting facts

Interesting Facts about 1-Hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione

This complex organic compound, often referred to as a polycyclic dihydroxy ketone, showcases the fascinating intricacies of chemical structures and properties. Here are some captivating insights about this molecule:

  • Structural Complexity: The name itself gives away the compound's elaborate structure, featuring not just a single cyclic component, but rather a combination of pentacyclic frameworks that significantly influences its reactivity and interactions.
  • Biological Relevance: Compounds like this one often exhibit biological activities that may include anti-inflammatory or antimicrobial properties, which can lead to their potential usage in pharmaceuticals.
  • Synthetic Chemistry: The synthesis of such a compound is a notable challenge in organic chemistry, requiring advanced synthetic techniques and strategies due to the numerous functional groups and chiral centers present.
  • Applications: Due to its unique properties, this compound could be investigated for applications in materials science and nanotechnology, particularly in the development of drug delivery systems or novel polymers.
  • Research Opportunities: Scientists are continually exploring the vast field of polycyclic compounds, making this an exciting subject for ongoing research and development in various branches of chemistry and biology.

The study of compounds like 1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione not only enhances our understanding of molecular diversity but also challenges chemists to innovate methods for their synthesis and application. In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas."


As we continue to unravel the mysteries of such complex substances, the potential for new discoveries in science and their applications is limitless.

Synonyms
Picrotin, analytical standard
MLS002707384
NSC129536
1-Hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione
SMR001306771
NCGC00017246-02
MLS002207223
CHEMBL1881068
BDBM81474
CHEBI:181758
NSC_5311359
NCGC00181138-01
CAS_124-87-8
DB-045573
BRD-A91822151-001-05-0
Picrotin, European Pharmacopoeia (EP) Reference Standard
1-HYDROXY-14-(2-HYDROXYPROPAN-2-YL)-13-METHYL-4,7,10-TRIOXAPENTACYCLO[6.4.1.1?,(1)(2).0(3),?.0?,(1)(3)]TETRADECANE-6,11-DIONE
3,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1a.alpha.,2a.beta.,3.beta.,6.beta.,6a.beta.,8aS*,8b.beta.,9R*)-
3,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, [1aR-(1a.alpha.,2a.beta.,3.beta.,6.beta.,6a.beta.,8aS*,8b.beta.,9S*)]-