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Metformin

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Identification
Molecular formula
C4H11N5
CAS number
1115-70-4
IUPAC name
1-(diaminomethylene)-2-phenyl-guanidine
State
State

Metformin is a solid at room temperature. It is typically formulated into tablets for medicinal use.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
129.16g/mol
Molar mass
129.1640g/mol
Density
1.3000g/cm3
Appearence

Metformin is a white to off-white crystalline powder. It is odorless and hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 1-(diaminomethylene)-2-phenyl-guanidine

When discussing the solubility of the compound 1-(diaminomethylene)-2-phenyl-guanidine (C4H11N5), several factors come into play:

  • Polarity: The presence of amine groups in the chemical structure indicates that this compound exhibits polar characteristics, which generally enhances solubility in polar solvents like water.
  • Hydrogen bonding: The multiple nitrogen atoms can form hydrogen bonds, further contributing to its potential solubility in aqueous solutions.
  • Temperature dependence: As with many organic compounds, solubility may increase with rise in temperature, allowing for greater interaction with solvents.
  • pH sensitivity: Being a guanidine derivative, the compound may have solubility that varies significantly with changes in pH, affecting its ionization state.

In summary, while specific solubility data for this particular compound may be limited, these factors suggest that it is likely to be soluble in polar solvents, with its solubility influenced by environmental conditions.

Interesting facts

Interesting Facts about 1-(Diaminomethylene)-2-phenyl-guanidine

1-(Diaminomethylene)-2-phenyl-guanidine, often abbreviated as DPG, is a fascinating compound with notable properties and applications in the field of chemistry and material science. Here are some intriguing aspects of DPG:

  • Biological Relevance: DPG has garnered attention due to its potential applications in medicinal chemistry. This compound can act as a precursor in the synthesis of various biologically active molecules.
  • Polymer Chemistry: Its unique structure makes it a valuable ingredient in creating polyurethanes, which are widely used in flexible and rigid foams, elastomers, and coatings.
  • Reactivity: DPG is known for its reactivity, particularly in reactions involving amines. This property can be utilized effectively in synthesizing complex organic compounds.
  • Research Tool: Chemists often use DPG as a reference or model compound in studies exploring the properties of guanidine derivatives, contributing to the understanding of guanidine functions in various chemical processes.

Furthermore, the compound has been employed in agricultural research, particularly in the development of agrochemicals that can affect the growth and development of plants in specific environments. Its role in enhancing crop resilience makes it a topic of interest for both researchers and farmers alike.

As scientists continue to explore the diverse applications of 1-(diaminomethylene)-2-phenyl-guanidine, its importance within both organic synthesis and industrial applications will likely only grow. This underscores the need for ongoing research and development in the field.

Synonyms
phenylbiguanide
1-Phenylbiguanide
102-02-3
Phenyl biguanide
Phenyldiguanide
phenyl diguanide
Phenylguanide
Imidodicarbonimidic diamide, N-phenyl-
N-Phenyl-N'-guanylguanidine
N-phenylimidodicarbonimidic diamide
1-(diaminomethylidene)-2-phenylguanidine
Biguanide, phenyl-
BIGUANIDE, 1-PHENYL-
N-phenylbiguanide
UNII-W8PKA3T2I3
EINECS 202-998-5
W8PKA3T2I3
MFCD00179077
CHEBI:75377
P 1426
CHEMBL13791
PHENYL BIGUANIDE [MI]
DTXSID90144508
1-carbamimidamido-N-phenylmethanimidamide
N-Phenyl-imidocarbonimidic diamide
SR-01000075565
N'-phenylbiguanide
N-Phenyliminodicarbonimidic Diamide
Spectrum_000472
Spectrum_001460
Tocris-0969
Lopac-P-120
Spectrum2_001190
Spectrum3_001604
Spectrum4_000058
Spectrum4_000320
Spectrum5_001179
1-Phenylbiguanide, 98%
Biomol-NT_000139
C8H11N5.HCl
NCIOpen2_007801
NCIOpen2_008753
Lopac0_000987
BSPBio_003207
KBioGR_000555
KBioGR_000940
KBioGR_002359
KBioSS_000952
KBioSS_001940
KBioSS_002362
MLS002153449
DivK1c_000282
DivK1c_000749
SCHEMBL467623
{[amino(phenylamino)methylidene]amino}methanimidamide
SPBio_001239
BPBio1_000156
GTPL2284
DTXCID6066999
SCHEMBL13919685
SCHEMBL19038542
BCBcMAP01_000062
HMS500O04
KBio1_000282
KBio1_000749
KBio2_000952
KBio2_001940
KBio2_002359
KBio2_003520
KBio2_004508
KBio2_004927
KBio2_006088
KBio2_007076
KBio2_007495
KBio3_002427
KBio3_002838
cMAP_000031
NINDS_000282
NINDS_000749
HMS3043D24
HMS3263E15
1-carbamimidoyl-3-phenyl-guanidine
Tox21_500987
BDBM50053596
HB2831
STK110224
AKOS002225097
AKOS021982884
N-diaminomethylene-N''-phenylguanidine
CCG-205067
LP00987
SDCCGSBI-0050960.P004
IDI1_000282
IDI1_000749
SMP1_000237
NCGC00015783-01
NCGC00015783-02
NCGC00015783-03
NCGC00015783-04
NCGC00015783-05
NCGC00015783-06
NCGC00015783-08
NCGC00015783-10
NCGC00024909-01
NCGC00024909-02
NCGC00024909-03
NCGC00024909-04
NCGC00261672-01
AS-63602
Br J Pharmacol 90: 229 (1987)
SMR000434198
SY053837
HY-101331
CS-0021169
EU-0100987
NS00023100
P-120
P1002
S2578
EN300-304862
T71531
AB00052412-10
SR-01000075565-1
1-(diaminomethylidene)-2-phenylguanidine hydrochloride
BRD-K31491153-003-02-6
BRD-K31491153-003-04-2
BRD-K31491153-003-05-9
Q25100298
1-(Diaminomethylidene)-2-phenyl-guanidine hydrochloride
Phenylbiguanide (N-Phenylbiguanide; PBG; 1-Phenylbiguanide)
1-{[{[AMINO(IMINO)METHYL]AMINO}(IMINO)METHYL]AMINO}BENZENE